KEGG PATHWAY: pprl00270

PATHWAY: pprl00270

Entry

pprl00270                   Pathway

Name

Cysteine and methionine metabolism - Poeciliopsis prolifica (blackstripe livebearer)

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

pprl00270

Cysteine and methionine metabolism

Module

pprl_M00034

Methionine salvage pathway [PATH:pprl00270]

pprl_M00035

Methionine degradation [PATH:pprl00270]

pprl_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pprl00270]

Other DBs

GO:	0006534 0006555

Organism

Poeciliopsis prolifica (blackstripe livebearer) [GN:pprl]

Gene

129377450

cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]

129379716

kynurenine--oxoglutarate transaminase 3-like isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]

129374243

kyat1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]

129361270

cbsb; cystathionine beta-synthase b isoform X1 [KO:K01697] [EC:4.2.1.22]

129378644

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

129374187

bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

129365809

betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]

129351370

zgc:172121; homocysteine S-methyltransferase isoform X1 [KO:K00547] [EC:2.1.1.10]

129352297

mtr; methionine synthase [KO:K00548] [EC:2.1.1.13]

129371973

mat2ab; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]

129366326

mat2aa; methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]

129374333

mat2al; methionine adenosyltransferase II, alpha-like [KO:K00789] [EC:2.5.1.6]

129370623

mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]

129359910

mat1a; S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]

129369196

amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

129372229

srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]

129368549

sms; spermine synthase [KO:K00802] [EC:2.5.1.22]

129367214

mtap; S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]

129361240

LOW QUALITY PROTEIN: purine nucleoside phosphorylase LACC1-like [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

129379255

LOW QUALITY PROTEIN: purine nucleoside phosphorylase LACC1-like [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

129366842

mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

129364408

apip; methylthioribulose-1-phosphate dehydratase isoform X1 [KO:K08964] [EC:4.2.1.109]

129374214

enoph1; enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]

129365231

adi1; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

129359982

tat; LOW QUALITY PROTEIN: tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]

129355706

il4i1; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]

129351402

LOW QUALITY PROTEIN: L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]

129376638

LOW QUALITY PROTEIN: L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]

129374881

gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

129363341

dnmt1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]

129375277

DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]

129365623

dnmt3ab; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]

129356255

DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]

129356256

LOW QUALITY PROTEIN: uncharacterized protein LOC129356256 [KO:K17399] [EC:2.1.1.37]

129370156

dnmt3ba; DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1 [KO:K17399] [EC:2.1.1.37]

129377003

LOW QUALITY PROTEIN: uncharacterized protein LOC129377003 [KO:K17399] [EC:2.1.1.37]

129377207

LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]

129372277

ahcyl1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]

129356155

LOW QUALITY PROTEIN: adenosylhomocysteinase B-like [KO:K01251] [EC:3.13.2.1]

129356652

S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]

129363806

S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]

129375615

LOW QUALITY PROTEIN: putative adenosylhomocysteinase 3 [KO:K01251] [EC:3.13.2.1]

129376179

LOW QUALITY PROTEIN: putative adenosylhomocysteinase 3 [KO:K01251] [EC:3.13.2.1]

129373745

bcat2; branched-chain-amino-acid aminotransferase, mitochondrial isoform X1 [KO:K00826] [EC:2.6.1.42]

129366531

agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

129360061

gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]

129375114

gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]

129371850

gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]

129365815

cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]

129360145

got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]

129364022

aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]

129366824

3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]

129363089

3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]

129363608

3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]

129360596

ldha; L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]

129366039

ldhbb; L-lactate dehydrogenase B-B chain isoform X1 [KO:K00016] [EC:1.1.1.27]

129354766

ldhba; L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]

129360126

mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]

129367606

mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]

129373072

LOW QUALITY PROTEIN: L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

129374762

sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

129361451

phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

129365878

psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors