KEGG   PATHWAY: psat00270
Entry
psat00270                   Pathway                                
Name
Cysteine and methionine metabolism - Pisum sativum (pea)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
psat00270  Cysteine and methionine metabolism
psat00270

Module
psat_M00021  Cysteine biosynthesis, serine => cysteine [PATH:psat00270]
psat_M00034  Methionine salvage pathway [PATH:psat00270]
psat_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:psat00270]
Other DBs
GO: 0006534 0006555
Organism
Pisum sativum (pea) [GN:psat]
Gene
127117593  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
127120035  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
127121056  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
127076039  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
127105413  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
127084756  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
127117588  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
127095019  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
127096649  cysteine synthase [KO:K01738] [EC:2.5.1.47]
127097430  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
127097431  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
127076808  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
127127349  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
127134086  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
127107097  cysteine synthase, mitochondrial-like [KO:K01738] [EC:2.5.1.47]
127107099  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
127107100  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
127107101  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
127127069  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
127092766  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
127091952  homocysteine S-methyltransferase 3-like [KO:K00547] [EC:2.1.1.10]
127118922  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
127130321  selenocysteine methyltransferase [KO:K00547] [EC:2.1.1.10]
127125739  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1-like [KO:K00549] [EC:2.1.1.14]
127126620  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
127083500  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
127138785  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
127092892  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
127074274  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
127125782  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
127132570  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
127115860  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
127073378  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
127119120  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
127074906  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
127128412  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
127128415  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
127136200  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
127088071  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
127119337  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
127075103  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
127082151  spermine synthase [KO:K00797] [EC:2.5.1.16]
127115345  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
127092673  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
127132446  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
127079839  5'-methylthioadenosine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
127098250  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
127098251  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
127135864  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
127086320  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
127091219  acireductone dioxygenase 2-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
127092759  acireductone dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
127084101  uncharacterized protein LOC127084101 [KO:K23977] [EC:2.6.1.117]
127084104  uncharacterized protein LOC127084104 [KO:K23977] [EC:2.6.1.117]
127075401  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
127107650  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
127091731  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
127083418  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
127083420  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
127120039  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
127074849  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
127131452  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
127132373  PWWP domain-containing protein 1 [KO:K17398] [EC:2.1.1.37]
127083178  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
127105509  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
127121586  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
127075998  1-aminocyclopropane-1-carboxylate synthase 1-like [KO:K20772] [EC:4.4.1.14]
127127029  1-aminocyclopropane-1-carboxylate synthase 2-like [KO:K20772] [EC:4.4.1.14]
127105086  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
127115465  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
127074336  1-aminocyclopropane-1-carboxylate synthase CMA101 [KO:K01762] [EC:4.4.1.14]
127120509  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
127101866  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
127101867  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
127101869  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
127084538  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
127106170  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
127118017  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
127118327  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
127077273  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
127082762  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
127083235  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
127126380  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
127126762  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
127083169  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
127107504  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
127100869  uncharacterized protein LOC127100869 [KO:K00133] [EC:1.2.1.11]
127115522  cystathionine gamma-synthase 1, chloroplastic-like isoform X1 [KO:K01739] [EC:2.5.1.48]
127128575  cystathionine gamma-synthase 1, chloroplastic-like isoform X1 [KO:K01739] [EC:2.5.1.48]
127087963  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
127120511  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
127106769  branched-chain-amino-acid aminotransferase 6-like [KO:K00826] [EC:2.6.1.42]
127127353  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127084448  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127107299  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127105571  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
127132329  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
127132331  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
127084859  aspartate aminotransferase 1 [KO:K14454] [EC:2.6.1.1]
127107436  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
127098047  aspartate aminotransferase P2, mitochondrial isoform X1 [KO:K00811] [EC:2.6.1.1]
127130955  thiosulfate/3-mercaptopyruvate sulfurtransferase 2-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
127074160  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
127120629  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
127135293  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
127083006  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
127107988  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
127091461  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
127091913  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
127132494  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
127096802  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
127076770  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
127098197  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
127108367  malate dehydrogenase 2, peroxisomal [KO:K00026] [EC:1.1.1.37]
127119190  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
127120517  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
127075368  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
127073794  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
127126567  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic [KO:K22846] [EC:2.5.1.144]
127097917  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
127100475  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
127105646  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
127120031  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
127074767  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
psat00010  Glycolysis / Gluconeogenesis
psat00250  Alanine, aspartate and glutamate metabolism
psat00260  Glycine, serine and threonine metabolism
psat00290  Valine, leucine and isoleucine biosynthesis
psat00430  Taurine and hypotaurine metabolism
psat00480  Glutathione metabolism
psat00620  Pyruvate metabolism
psat00640  Propanoate metabolism
psat00770  Pantothenate and CoA biosynthesis
psat00900  Terpenoid backbone biosynthesis
psat00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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