Entry Name Progesterone-mediated oocyte maturation - Polyodon spathula (Mississippi paddlefish)
Description Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map pspa04914 Progesterone-mediated oocyte maturation
Ortholog table Other DBs Organism Polyodon spathula (Mississippi paddlefish) [GN:
pspa ]
Gene 121300582 phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649 ]
121300755 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
121326688 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
121301490 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
121317026 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
121330558 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
121326758 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121328810 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
121323116 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
121329032 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
121305638 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922 ] [EC:2.7.1.153 ]
121297680 guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630 ]
121299816 guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
121299890 guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
121329128 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
121318357 guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630 ]
121319742 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
121296885 cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602 ]
121298851 cytoplasmic polyadenylation element-binding protein 1-like isoform X1 [KO:K02602 ]
121294278 cytoplasmic polyadenylation element-binding protein 1-like [KO:K02602 ]
121321878 cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602 ]
121329934 cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602 ]
121324240 cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602 ]
121324613 cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602 ]
121325233 cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602 ]
121305212 pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633 ] [EC:2.7.11.1 ]
121300878 mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679 ]
121322670 mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537 ]
121328397 mitotic spindle assembly checkpoint protein MAD2B-like isoform X1 [KO:K13728 ]
121301532 fzr1a; fizzy/cell division cycle 20 related 1a isoform X1 [KO:K03364 ]
121317167 anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348 ]
121299765 anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352 ]
121320698 LOW QUALITY PROTEIN: cell division cycle protein 16 homolog [KO:K03353 ]
121321149 anaphase-promoting complex subunit 10-like isoform X1 [KO:K03357 ]
121302730 anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference Authors Schmitt A, Nebreda AR.
Title Signalling pathways in oocyte meiotic maturation.
Journal J Cell Sci 115:2457-9 (2002)
Reference Authors Cato AC, Nestl A, Mink S.
Title Rapid actions of steroid receptors in cellular signaling pathways.
Journal Reference Authors Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
Title The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Journal Reference Authors Nebreda AR, Ferby I.
Title Regulation of the meiotic cell cycle in oocytes.
Journal Reference Authors Ferrell JE Jr.
Title Xenopus oocyte maturation: new lessons from a good egg.
Journal Reference Authors Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Title Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Journal Reference Authors Duckworth BC, Weaver JS, Ruderman JV.
Title G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Journal Reference Authors Abrieu A, Doree M, Fisher D.
Title The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Journal J Cell Sci 114:257-67 (2001)
Related KO pathway LinkDB All DBs
