KEGG   PATHWAY: pspa04010
Entry
pspa04010                   Pathway                                
Name
MAPK signaling pathway - Polyodon spathula (Mississippi paddlefish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pspa04010  MAPK signaling pathway
pspa04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121294311  [KO:K04402]
121294349  [KO:K05866] [EC:3.1.3.48]
121294354  [KO:K04349]
121294410  [KO:K05087] [EC:2.7.10.1]
121294414  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
121294462  [KO:K04355]
121294557  [KO:K04368] [EC:2.7.12.2]
121294598  [KO:K07830]
121294655  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121294693  [KO:K04463] [EC:2.7.12.2]
121294705  [KO:K03175] [EC:2.3.2.27]
121294909  [KO:K13769]
121294911  [KO:K02833]
121295060  fgf3; fibroblast growth factor 3 [KO:K04358]
121295062  fgf7; fibroblast growth factor 7 [KO:K04358]
121295106  [KO:K04526]
121295124  fgf4; fibroblast growth factor 4 [KO:K04358]
121295130  [KO:K04434]
121295176  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
121295227  [KO:K05450]
121295305  [KO:K04433] [EC:2.7.12.2]
121295451  [KO:K04430] [EC:2.7.12.2]
121295492  [KO:K04407] [EC:2.7.11.1]
121295549  [KO:K02677] [EC:2.7.11.13]
121295554  [KO:K04869]
121295555  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
121295556  [KO:K04866]
121295588  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
121295601  [KO:K04373] [EC:2.7.11.1]
121295627  [KO:K04357]
121295764  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
121295787  [KO:K04358]
121295867  [KO:K04364]
121296073  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
121296107  [KO:K17333]
121296108  [KO:K04433] [EC:2.7.12.2]
121296218  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
121296282  [KO:K04430] [EC:2.7.12.2]
121296291  [KO:K04348] [EC:3.1.3.16]
121296314  [KO:K02580]
121296360  [KO:K02677] [EC:2.7.11.13]
121296363  [KO:K04869]
121296364  [KO:K04870]
121296365  [KO:K04866]
121296442  [KO:K04364]
121296521  [KO:K04393]
121296673  [KO:K07861]
121296796  [KO:K05449]
121296940  [KO:K18496]
121296957  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121296992  [KO:K05095] [EC:2.7.10.1]
121297140  [KO:K04438]
121297145  [KO:K21278] [EC:3.1.3.16 3.1.3.48]
121297147  [KO:K04371] [EC:2.7.11.24]
121297173  [KO:K05097] [EC:2.7.10.1]
121297223  [KO:K04358]
121297226  [KO:K04442] [EC:2.7.11.1]
121297264  [KO:K05090] [EC:2.7.10.1]
121297330  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
121297359  [KO:K04358]
121297374  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
121297518  [KO:K04429] [EC:2.7.11.1]
121297547  [KO:K02187] [EC:3.4.22.56]
121297616  [KO:K04348] [EC:3.1.3.16]
121297674  [KO:K04411]
121297703  [KO:K05465]
121297980  [KO:K04366] [EC:2.7.11.1]
121298007  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121298079  [KO:K03283]
121298099  [KO:K03283]
121298112  [KO:K04444] [EC:2.7.11.1]
121298148  [KO:K04363] [EC:2.7.10.1]
121298152  [KO:K05091] [EC:2.7.10.1]
121298155  [KO:K04859]
121298159  [KO:K04377]
121298162  [KO:K05098] [EC:2.7.10.1]
121298165  [KO:K05098] [EC:2.7.10.1]
121298208  [KO:K04851]
121298255  [KO:K04441] [EC:2.7.11.24]
121298277  [KO:K04860]
121298556  [KO:K03283]
121298629  [KO:K09784]
121298634  [KO:K09782]
121298716  [KO:K03156]
121298723  [KO:K03173] [EC:2.3.2.27]
121298724  [KO:K03156]
121298782  [KO:K04349]
121298847  [KO:K04358]
121298882  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121298929  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121298974  [KO:K02308]
121299180  [KO:K04463] [EC:2.7.12.2]
121299406  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
121299441  [KO:K18019] [EC:3.1.3.48]
121299458  [KO:K02582]
121299655  [KO:K04443] [EC:2.7.11.1]
121299741  [KO:K02582]
121299777  [KO:K04429] [EC:2.7.11.1]
121299863  [KO:K04857]
121299882  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121299883  [KO:K04441] [EC:2.7.11.24]
121299885  [KO:K04857]
121299906  [KO:K04376]
121299961  [KO:K05453]
121299977  [KO:K04353]
121299985  [KO:K04438]
121300003  [KO:K04353]
121300052  [KO:K04442] [EC:2.7.11.1]
121300074  [KO:K07828]
121300091  [KO:K07828]
121300124  [KO:K04455]
121300243  [KO:K05459]
121300319  [KO:K05459]
121300580  [KO:K25414]
121300659  [KO:K04868]
121300692  [KO:K05462]
121300714  [KO:K04527] [EC:2.7.10.1]
121300719  [KO:K19662] [EC:2.7.11.13]
121300746  [KO:K04432] [EC:2.7.12.2]
121300795  [KO:K04855]
121300828  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121300834  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
121300879  [KO:K04346]
121300896  [KO:K04449]
121300913  [KO:K04416] [EC:2.7.11.25]
121300937  [KO:K04359]
121301031  [KO:K04402]
121301053  [KO:K04358]
121301266  [KO:K04392]
121301294  [KO:K04369] [EC:2.7.12.2]
121301362  [KO:K05462]
121301392  [KO:K04372] [EC:2.7.11.1]
121301438  [KO:K04449]
121301454  [KO:K04358]
121301569  [KO:K04440] [EC:2.7.11.24]
121301595  [KO:K04372] [EC:2.7.11.1]
121301635  [KO:K25414]
121301706  [KO:K04380]
121301783  [KO:K02583]
121301839  [KO:K05083] [EC:2.7.10.1]
121301869  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
121301894  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
121302005  [KO:K04862]
121302007  [KO:K04862]
121302061  [KO:K04519]
121302069  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121302100  [KO:K04402]
121302121  [KO:K04402]
121302141  [KO:K04402]
121302147  [KO:K04873]
121302179  [KO:K04358]
121302250  [KO:K04872]
121302294  [KO:K07209] [EC:2.7.11.10]
121302321  [KO:K04362] [EC:2.7.10.1]
121302376  [KO:K04348] [EC:3.1.3.16]
121302388  [KO:K04871]
121302494  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
121302556  [KO:K04358]
121302719  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121302745  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
121302747  [KO:K05096] [EC:2.7.10.1]
121302926  [KO:K04373] [EC:2.7.11.1]
121302937  [KO:K05462]
121303033  tgfa; protransforming growth factor alpha [KO:K08774]
121303041  fgf17; fibroblast growth factor 17 [KO:K04358]
121303070  [KO:K04362] [EC:2.7.10.1]
121303088  [KO:K04348] [EC:3.1.3.16]
121303108  [KO:K04519]
121303111  [KO:K04519]
121303208  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121303214  [KO:K07209] [EC:2.7.11.10]
121303256  [KO:K04373] [EC:2.7.11.1]
121303423  angpt2b; angiopoietin-2b [KO:K05466]
121303470  [KO:K04381]
121303549  [KO:K05121] [EC:2.7.10.1]
121303585  [KO:K04448]
121303757  [KO:K04457] [EC:3.1.3.16]
121303823  [KO:K09253]
121303827  [KO:K04350]
121303838  [KO:K04456] [EC:2.7.11.1]
121303842  [KO:K04460] [EC:3.1.3.16]
121303891  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
121303974  [KO:K03283]
121304127  [KO:K04368] [EC:2.7.12.2]
121304133  [KO:K02308]
121304196  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121304363  [KO:K03156]
121304482  [KO:K25416]
121304484  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
121304535  [KO:K04347]
121304626  [KO:K04441] [EC:2.7.11.24]
121304628  [KO:K18019] [EC:3.1.3.48]
121304667  [KO:K04441] [EC:2.7.11.24]
121304669  [KO:K04443] [EC:2.7.11.1]
121304688  [KO:K04358]
121304729  [KO:K04376]
121304734  [KO:K05453]
121304821  [KO:K04457] [EC:3.1.3.16]
121304828  [KO:K04456] [EC:2.7.11.1]
121304857  [KO:K04418] [EC:2.7.11.25]
121304906  [KO:K13375]
121304915  [KO:K05452]
121304926  [KO:K09253]
121304965  [KO:K04460] [EC:3.1.3.16]
121305004  [KO:K04350]
121305215  [KO:K04371] [EC:2.7.11.24]
121305491  [KO:K08845] [EC:2.7.11.1]
121305498  [KO:K04853]
121305541  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
121305685  [KO:K04451]
121305701  [KO:K04439]
121305882  [KO:K04526]
121305969  [KO:K12457]
121306093  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
121306111  [KO:K04867]
121306116  [KO:K04454]
121306135  [KO:K04374]
121306136  [KO:K04374]
121306164  [KO:K17386]
121306175  [KO:K07860]
121306183  [KO:K07860]
121306184  [KO:K04352]
121306198  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
121306306  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
121306334  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
121306370  rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
121306372  [KO:K12326]
121306517  [KO:K04451]
121306612  [KO:K04439]
121306674  [KO:K04849]
121306749  [KO:K04429] [EC:2.7.11.1]
121306751  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
121306857  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
121306863  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
121307005  [KO:K05462]
121307195  [KO:K04872]
121307210  [KO:K04871]
121307228  [KO:K04873]
121307641  [KO:K04379]
121307658  [KO:K04379]
121307738  [KO:K04371] [EC:2.7.11.24]
121307826  [KO:K04437]
121307859  [KO:K04377]
121307986  [KO:K04729]
121308000  [KO:K04405]
121308008  hspb1; heat shock protein beta-1 [KO:K04455]
121308330  [KO:K04426] [EC:2.7.11.25]
121308649  taok1a; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
121308658  crk; adapter molecule crk isoform X1 [KO:K04438]
121308734  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
121308742  nf1a; neurofibromin isoform X1 [KO:K08052]
121308815  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
121308942  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
121308980  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
121309021  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
121309044  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
121309118  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
121309150  [KO:K04405]
121309497  [KO:K03283]
121309564  [KO:K04527] [EC:2.7.10.1]
121309579  [KO:K04402]
121309606  [KO:K03173] [EC:2.3.2.27]
121309852  ntrk1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
121309866  [KO:K04421] [EC:2.7.11.25]
121309888  [KO:K04729]
121309892  [KO:K05462]
121309895  efna3b; ephrin-A3b [KO:K05462]
121310071  [KO:K04419] [EC:2.7.11.25]
121310074  rela; transcription factor p65 isoform X1 [KO:K04735]
121310087  [KO:K12361]
121310175  [KO:K04345] [EC:2.7.11.11]
121310212  [KO:K04437]
121310834  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
121311604  [KO:K04415] [EC:2.7.11.25]
121312688  [KO:K04863]
121312786  [KO:K12326]
121312913  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121312929  [KO:K04352]
121312949  [KO:K04454]
121312968  [KO:K02583]
121312996  [KO:K05866] [EC:3.1.3.48]
121313088  [KO:K04674] [EC:2.7.11.30]
121313118  [KO:K04361] [EC:2.7.10.1]
121313233  [KO:K04412]
121313267  [KO:K05465]
121313331  [KO:K04446]
121314031  [KO:K04421] [EC:2.7.11.25]
121314032  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
121314104  [KO:K04415] [EC:2.7.11.25]
121314145  [KO:K04863]
121314498  [KO:K04448]
121314515  [KO:K05121] [EC:2.7.10.1]
121314569  [KO:K04674] [EC:2.7.11.30]
121314598  [KO:K04361] [EC:2.7.10.1]
121314608  [KO:K04377]
121314675  [KO:K02583]
121314717  [KO:K04388] [EC:2.7.11.30]
121314840  [KO:K04446]
121314917  [KO:K05465]
121314948  stk3; serine/threonine-protein kinase 3 [KO:K04412]
121315029  [KO:K05462]
121315455  [KO:K04427] [EC:2.7.11.25]
121315677  [KO:K12362]
121315693  [KO:K04378]
121315739  [KO:K04402]
121315746  [KO:K04402]
121315754  [KO:K04402]
121315760  angpt2a; angiopoietin-2a [KO:K05466]
121315761  [KO:K04402]
121315764  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
121315785  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
121315825  [KO:K04404]
121315952  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
121315977  [KO:K13376]
121315991  [KO:K05448]
121316056  [KO:K04456] [EC:2.7.11.1]
121316065  [KO:K17534] [EC:2.7.11.25]
121316113  [KO:K06268]
121316125  [KO:K04440] [EC:2.7.11.24]
121316302  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
121316350  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
121316389  [KO:K03099]
121316398  [KO:K04426] [EC:2.7.11.25]
121316675  [KO:K04461] [EC:3.1.3.16]
121316717  [KO:K04428] [EC:2.7.11.25]
121316750  [KO:K04416] [EC:2.7.11.25]
121316755  [KO:K12362]
121316776  srfb; serum response factor b isoform X1 [KO:K04378]
121316869  [KO:K04373] [EC:2.7.11.1]
121316886  [KO:K03099]
121316887  [KO:K04406] [EC:2.7.11.1]
121316932  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
121316944  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
121317043  [KO:K04402]
121317053  [KO:K04468] [EC:2.7.11.24]
121317078  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
121317109  [KO:K13376]
121317116  [KO:K04402]
121317131  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
121317179  [KO:K04456] [EC:2.7.11.1]
121317191  [KO:K17534] [EC:2.7.11.25]
121317240  [KO:K06268]
121317588  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121317620  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121317751  [KO:K05466]
121317842  [KO:K04861]
121317898  [KO:K22428]
121317906  [KO:K04358]
121317948  [KO:K04441] [EC:2.7.11.24]
121317949  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121317980  [KO:K07836]
121318027  [KO:K04458] [EC:3.1.3.48]
121318076  [KO:K04358]
121318174  [KO:K04358]
121318191  [KO:K05460]
121318192  [KO:K04858]
121318212  [KO:K04435]
121318228  [KO:K05099] [EC:2.7.10.1]
121318385  [KO:K07827]
121318433  igf1; insulin-like growth factor I [KO:K05459]
121318490  [KO:K21946] [EC:3.1.3.16 3.1.3.48]
121318493  kitlga; kit ligand a isoform X1 [KO:K05461]
121318501  [KO:K04365] [EC:2.7.11.1]
121318532  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121318570  [KO:K04356]
121318589  [KO:K04850]
121318631  [KO:K06268]
121318701  [KO:K04360] [EC:2.7.10.1]
121318726  [KO:K04358]
121318776  [KO:K04373] [EC:2.7.11.1]
121318845  [KO:K05096] [EC:2.7.10.1]
121318960  [KO:K04407] [EC:2.7.11.1]
121319093  [KO:K22428]
121319201  [KO:K03283]
121319202  [KO:K03283]
121319203  [KO:K03283]
121319204  [KO:K03283]
121319206  [KO:K03283]
121319472  [KO:K04411]
121319479  [KO:K05465]
121319504  [KO:K04356]
121319532  [KO:K04850]
121319534  [KO:K04861]
121319596  [KO:K04365] [EC:2.7.11.1]
121319604  [KO:K05461]
121319605  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
121319666  [KO:K05459]
121319701  [KO:K09784]
121319713  [KO:K07827]
121319884  [KO:K05099] [EC:2.7.10.1]
121319908  [KO:K05460]
121319909  [KO:K04858]
121319927  [KO:K04435]
121319978  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
121320015  [KO:K04358]
121320036  [KO:K04363] [EC:2.7.10.1]
121320044  kita; mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
121320053  [KO:K05098] [EC:2.7.10.1]
121320066  [KO:K04458] [EC:3.1.3.48]
121320084  [KO:K07836]
121320343  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
121320364  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
121320452  [KO:K04386]
121320457  [KO:K04386]
121320508  [KO:K02187] [EC:3.4.22.56]
121320622  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
121320704  [KO:K05449]
121321265  [KO:K05096] [EC:2.7.10.1]
121321385  [KO:K04390]
121321602  [KO:K04358]
121321642  [KO:K04469]
121321798  [KO:K04440] [EC:2.7.11.24]
121321809  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121321953  [KO:K02580]
121321987  [KO:K05093] [EC:2.7.10.1]
121321999  [KO:K04348] [EC:3.1.3.16]
121322029  [KO:K04420] [EC:2.7.11.25]
121322207  [KO:K04450]
121322217  zak; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
121322227  [KO:K04422] [EC:2.7.11.25]
121322330  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121322376  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121322389  [KO:K04865]
121322455  [KO:K05085] [EC:2.7.10.1]
121322456  [KO:K04357]
121322484  [KO:K07831]
121322602  [KO:K07831]
121322837  [KO:K04388] [EC:2.7.11.30]
121322860  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
121322874  [KO:K04462] [EC:2.1.1.367]
121322906  [KO:K04424] [EC:2.7.11.25]
121322941  [KO:K05450]
121323045  [KO:K08053]
121323081  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
121323087  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
121323145  [KO:K05085] [EC:2.7.10.1]
121323228  [KO:K04865]
121323244  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
121323264  [KO:K04450]
121323555  [KO:K04723]
121323680  fgf2; fibroblast growth factor 2 [KO:K18497]
121323793  sos2; son of sevenless homolog 2 [KO:K03099]
121323802  [KO:K02583]
121323818  [KO:K04453]
121323823  [KO:K16342] [EC:3.1.1.4]
121323875  [KO:K16859]
121323920  [KO:K04358]
121323962  [KO:K05449]
121324174  [KO:K04440] [EC:2.7.11.24]
121324176  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121324207  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
121324221  [KO:K04380]
121324293  [KO:K16342] [EC:3.1.1.4]
121324390  [KO:K04350]
121324393  [KO:K04379]
121324394  [KO:K04379]
121324461  [KO:K21278] [EC:3.1.3.16 3.1.3.48]
121324486  [KO:K04862]
121324524  [KO:K05090] [EC:2.7.10.1]
121324562  [KO:K05097] [EC:2.7.10.1]
121324586  [KO:K05083] [EC:2.7.10.1]
121324739  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
121324756  [KO:K05089] [EC:2.7.10.1]
121324804  [KO:K13377]
121324836  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
121324895  [KO:K04421] [EC:2.7.11.25]
121324957  [KO:K04445] [EC:2.7.11.1]
121324996  [KO:K04348] [EC:3.1.3.16]
121324997  [KO:K05095] [EC:2.7.10.1]
121325159  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
121325188  [KO:K04469]
121325211  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121325473  [KO:K04358]
121325532  [KO:K05094] [EC:2.7.10.1]
121325632  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121325679  [KO:K03158]
121325682  [KO:K04440] [EC:2.7.11.24]
121325747  [KO:K04393]
121325811  [KO:K04348] [EC:3.1.3.16]
121325966  [KO:K03171]
121325980  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
121326089  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121326269  [KO:K04358]
121326375  [KO:K04402]
121326429  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121326444  [KO:K08018]
121326514  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
121326662  [KO:K25415]
121326704  [KO:K04462] [EC:2.1.1.367]
121326749  [KO:K04345] [EC:2.7.11.11]
121326780  [KO:K16342] [EC:3.1.1.4]
121326893  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121326933  fgf5; fibroblast growth factor 5 [KO:K04358]
121326943  [KO:K04723]
121327132  [KO:K04448]
121327227  [KO:K08053]
121327632  [KO:K04407] [EC:2.7.11.1]
121327678  [KO:K04386]
121328139  [KO:K04358]
121328459  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121328533  [KO:K04393]
121328554  [KO:K04366] [EC:2.7.11.1]
121328616  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121328667  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
121328718  [KO:K05103] [EC:2.7.10.1]
121328728  [KO:K05103] [EC:2.7.10.1]
121328816  [KO:K04859]
121328825  [KO:K04851]
121328847  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
121328899  [KO:K18497]
121329109  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121329136  [KO:K04860]
121329221  [KO:K04444] [EC:2.7.11.1]
121329240  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121329493  [KO:K04358]
121329499  [KO:K13769]
121329509  [KO:K04355]
121329595  [KO:K18018] [EC:3.1.3.48]
121329756  [KO:K04453]
121329814  [KO:K04457] [EC:3.1.3.16]
121329873  [KO:K03175] [EC:2.3.2.27]
121329880  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
121329950  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121329965  [KO:K07830]
121330210  [KO:K04456] [EC:2.7.11.1]
121330283  [KO:K16859]
121330294  [KO:K04445] [EC:2.7.11.1]
121330312  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121330319  [KO:K04350]
121330373  fgf19; fibroblast growth factor 19 [KO:K22603]
121330383  [KO:K04358]
121330389  [KO:K04526]
121330422  [KO:K04434]
121330521  [KO:K04359]
121330672  [KO:K16342] [EC:3.1.1.4]
121330683  [KO:K04389]
121330686  [KO:K04868]
121330694  [KO:K25415]
121330795  [KO:K04392]
121330854  [KO:K04432] [EC:2.7.12.2]
121330903  [KO:K05094] [EC:2.7.10.1]
121330907  [KO:K04402]
121330935  [KO:K04448]
121330947  [KO:K04852]
121330953  [KO:K04436]
121330967  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
121331016  [KO:K04345] [EC:2.7.11.11]
121331034  [KO:K19662] [EC:2.7.11.13]
121331110  [KO:K04855]
121331272  [KO:K04346]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pspa04070  Phosphatidylinositol signaling system
pspa04110  Cell cycle
pspa04115  p53 signaling pathway
pspa04210  Apoptosis
pspa04310  Wnt signaling pathway
KO pathway
ko04010   

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