KEGG   PATHWAY: qlo00270
Entry
qlo00270                    Pathway                                
Name
Cysteine and methionine metabolism - Quercus lobata (valley oak)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
qlo00270  Cysteine and methionine metabolism
qlo00270

Module
qlo_M00021  Cysteine biosynthesis, serine => cysteine [PATH:qlo00270]
qlo_M00034  Methionine salvage pathway [PATH:qlo00270]
qlo_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:qlo00270]
Other DBs
GO: 0006534 0006555
Organism
Quercus lobata (valley oak) [GN:qlo]
Gene
115976138  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
115950817  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
115950839  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
115957575  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
115992037  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
115992176  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
115994451  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
115963392  cysteine synthase, chloroplastic/chromoplastic-like [KO:K01738] [EC:2.5.1.47]
115979872  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
115979975  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
115979977  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
115979979  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
115979981  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
115979983  cysteine synthase [KO:K01738] [EC:2.5.1.47]
115980572  putative inactive cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
115981587  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
115968253  cysteine synthase 1-like isoform X1 [KO:K01738] [EC:2.5.1.47]
115955992  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
115994564  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial-like [KO:K13034] [EC:2.5.1.47 4.4.1.9]
115986890  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
115952458  cystathionine beta-lyase, chloroplastic-like [KO:K01760] [EC:4.4.1.13]
115953492  cystathionine beta-lyase, chloroplastic-like [KO:K01760] [EC:4.4.1.13]
115969840  selenocysteine methyltransferase-like isoform X1 [KO:K00547] [EC:2.1.1.10]
115990524  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
115993590  homocysteine S-methyltransferase 3 [KO:K00547] [EC:2.1.1.10]
115976596  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
115952855  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
115995314  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
115980034  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
115952565  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
115970907  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
115973157  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
115977307  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
115995091  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
115995334  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
115975869  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
115960231  spermine synthase [KO:K00797] [EC:2.5.1.16]
115965642  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
115982669  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
115994087  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
115980241  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
115981763  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
115981915  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
115967314  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2-like [KO:K01244] [EC:3.2.2.16]
115968214  methylthioribose kinase isoform X1 [KO:K00899] [EC:2.7.1.100]
115968740  methylthioribose-1-phosphate isomerase isoform X1 [KO:K08963] [EC:5.3.1.23]
115956855  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 2 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
115957296  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
115993954  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
115949613  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
115960068  uncharacterized protein LOC115960068 [KO:K23977] [EC:2.6.1.117]
115955637  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
115973365  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
115957610  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
115957997  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
115958534  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
115991676  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
115975186  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
115963274  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
115978052  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
115950848  putative DNA (cytosine-5)-methyltransferase CMT1 isoform X1 [KO:K00558] [EC:2.1.1.37]
115971602  DNA (cytosine-5)-methyltransferase CMT2-like [KO:K00558] [EC:2.1.1.37]
115979511  uncharacterized protein LOC115979511 [KO:K17398] [EC:2.1.1.37]
115963219  adenosylhomocysteinase-like isoform X1 [KO:K01251] [EC:3.13.2.1]
115963367  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
115983881  1-aminocyclopropane-1-carboxylate synthase 1 isoform X1 [KO:K20772] [EC:4.4.1.14]
115970076  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
115972430  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
115978352  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
115950708  1-aminocyclopropane-1-carboxylate synthase CMA101 [KO:K01762] [EC:4.4.1.14]
115978140  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
115978964  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
115957337  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
115957349  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
115957361  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
115992552  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
115958993  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
115976366  aspartokinase 3, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
115982061  aspartokinase 1, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
115960042  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
115968272  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
115982119  uncharacterized protein LOC115982119 [KO:K00133] [EC:1.2.1.11]
115992772  homoserine kinase [KO:K00872] [EC:2.7.1.39]
115976906  cystathionine gamma-synthase 1, chloroplastic [KO:K27857] [EC:2.5.1.160]
115994905  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
115968947  branched-chain-amino-acid aminotransferase 6-like [KO:K00826] [EC:2.6.1.42]
115969638  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
115969639  branched-chain-amino-acid aminotransferase 6-like isoform X1 [KO:K00826] [EC:2.6.1.42]
115973043  LOW QUALITY PROTEIN: branched-chain-amino-acid aminotransferase 5, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
115973061  branched-chain amino acid aminotransferase 1, mitochondrial-like isoform X1 [KO:K00826] [EC:2.6.1.42]
115994271  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
115950148  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
115952225  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
115984842  LOW QUALITY PROTEIN: alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
115984880  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
115951686  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
115971319  glutamate--cysteine ligase, chloroplastic-like isoform X1 [KO:K01919] [EC:6.3.2.2]
115981748  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
115965143  aspartate aminotransferase, cytoplasmic isozyme 2-like [KO:K14454] [EC:2.6.1.1]
115971772  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
115953758  aspartate aminotransferase, mitochondrial-like isoform X1 [KO:K14455] [EC:2.6.1.1]
115953818  aspartate aminotransferase, mitochondrial-like isoform X1 [KO:K14455] [EC:2.6.1.1]
115958618  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
115974884  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
115984229  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
115988169  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
115969884  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
115969941  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
115969942  L-lactate dehydrogenase A-like [KO:K00016] [EC:1.1.1.27]
115964653  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like [KO:K05396] [EC:4.4.1.15]
115965493  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
115982373  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
115981667  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
115968171  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
115972135  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
115994633  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
115986563  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
115986564  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
115986565  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
115986569  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
115971289  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
115971290  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
115992354  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
115995496  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
115963820  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
115968387  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
115956030  malate dehydrogenase, mitochondrial isoform X1 [KO:K00026] [EC:1.1.1.37]
115952724  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic [KO:K22846] [EC:2.5.1.144]
115969319  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
115989704  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
115974127  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
115995368  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
115950715  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01102  O-Phospho-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
qlo00010  Glycolysis / Gluconeogenesis
qlo00250  Alanine, aspartate and glutamate metabolism
qlo00260  Glycine, serine and threonine metabolism
qlo00290  Valine, leucine and isoleucine biosynthesis
qlo00430  Taurine and hypotaurine metabolism
qlo00480  Glutathione metabolism
qlo00620  Pyruvate metabolism
qlo00640  Propanoate metabolism
qlo00770  Pantothenate and CoA biosynthesis
qlo00900  Terpenoid backbone biosynthesis
qlo00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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