KEGG   PATHWAY: rbb00260
Entry
rbb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhinopithecus bieti (black snub-nosed monkey)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rbb00260  Glycine, serine and threonine metabolism
rbb00260

Module
rbb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rbb00260]
rbb_M00047  Creatine pathway [PATH:rbb00260]
rbb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:rbb00260]
rbb_M00555  Betaine biosynthesis, choline => betaine [PATH:rbb00260]
rbb_M00621  Glycine cleavage system [PATH:rbb00260]
rbb_M00974  Betaine metabolism, animals, betaine => glycine [PATH:rbb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108534273  LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
108516621  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
108519696  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
108521078  AGXT; LOW QUALITY PROTEIN: serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
108516211  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
108522338  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
108534620  PGAM1; LOW QUALITY PROTEIN: phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
108529209  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
108544009  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
108528560  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
108532129  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
108522539  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
108528167  PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
108542649  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
108526511  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
108521433  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
108536710  L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]
108522344  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
108540600  ALAS2; LOW QUALITY PROTEIN: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
108522075  MAOB; LOW QUALITY PROTEIN: amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
108517832  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
108526775  AOC2; LOW QUALITY PROTEIN: retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
108526778  LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
108518731  GLDC; LOW QUALITY PROTEIN: glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
108527245  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
108526988  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
108540480  DLD; LOW QUALITY PROTEIN: dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
108539496  GCSH; glycine cleavage system H protein, mitochondrial isoform X1 [KO:K02437]
108534390  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
108543800  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
108530126  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
108530253  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
108515200  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
108537700  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
108528900  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
108528899  DMGDH; LOW QUALITY PROTEIN: dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
108517272  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
108513254  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
108533480  GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
108529529  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
108534624  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
108512208  SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
108512211  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
108526307  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rbb00010  Glycolysis / Gluconeogenesis
rbb00020  Citrate cycle (TCA cycle)
rbb00230  Purine metabolism
rbb00250  Alanine, aspartate and glutamate metabolism
rbb00270  Cysteine and methionine metabolism
rbb00290  Valine, leucine and isoleucine biosynthesis
rbb00330  Arginine and proline metabolism
rbb00470  D-Amino acid metabolism
rbb00564  Glycerophospholipid metabolism
rbb00600  Sphingolipid metabolism
rbb00620  Pyruvate metabolism
rbb00630  Glyoxylate and dicarboxylate metabolism
rbb00640  Propanoate metabolism
rbb00860  Porphyrin metabolism
rbb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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