KEGG   PATHWAY: rro04514
Entry
rro04514                    Pathway                                
Name
Cell adhesion molecules - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
rro04514  Cell adhesion molecules
rro04514

Other DBs
GO: 0050839
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104665931  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
104665926  CD2; T-cell surface antigen CD2 [KO:K06449]
104669930  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
104657607  IGSF11; immunoglobulin superfamily member 11 isoform X2 [KO:K06791]
104657616  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
104663753  CD274; programmed cell death 1 ligand 1 [KO:K06745]
104653590  CD28; T-cell-specific surface glycoprotein CD28 isoform X3 [KO:K06470]
104667916  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
104653594  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
104659932  ICOSLG; ICOS ligand isoform X1 [KO:K06710]
104653595  ICOS; inducible T-cell costimulator [KO:K06713]
104657986  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
104657985  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
104673877  HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752]
104673884  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
104673840  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
104673850  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
104673860  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
104673868  HLA class II histocompatibility antigen, DRB1-10 beta chain [KO:K06752]
104666619  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
104666621  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
104666623  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
104681408  uncharacterized protein LOC104681408 [KO:K10785]
104681410  uncharacterized protein LOC104681410 [KO:K10785]
104680099  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
104670209  patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
104668193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-42 alpha chain-like [KO:K06751]
104674706  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104661905  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
115897009  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
104676771  mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
104678084  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
104668434  HLA class I histocompatibility antigen, A-30 alpha chain isoform X1 [KO:K06751]
104677089  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
104673193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751]
104676774  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104666183  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
104678248  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
104674168  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
104674169  CD8B; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD8 beta chain [KO:K06459]
104663754  PDCD1LG2; programmed cell death 1 ligand 2 isoform X2 [KO:K06708]
104678064  CD276; CD276 antigen isoform X1 [KO:K06746]
104665919  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
104673072  PDCD1; programmed cell death protein 1 isoform X1 [KO:K06744]
104678812  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
104682444  CD40LG; CD40 ligand [KO:K03161]
104674411  ALCAM; CD166 antigen isoform X1 [KO:K06547]
104679400  CD6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
104673469  PVR; poliovirus receptor isoform X1 [KO:K06539]
115891992  poliovirus receptor homolog [KO:K06539]
104658791  CD226; CD226 antigen isoform X1 [KO:K06567]
104673464  NECTIN2; nectin-2 [KO:K06531]
104680813  TIGIT; T-cell immunoreceptor with Ig and ITIM domains isoform X3 [KO:K16350]
104681602  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
104659958  ITGB2; integrin beta-2 [KO:K06464]
104670485  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
104675450  ICAM2; intercellular adhesion molecule 2 isoform X1 [KO:K06523]
104670480  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
104667109  CD22; B-cell receptor CD22 isoform X3 [KO:K06467]
104658267  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
104674599  SIGLEC1; sialoadhesin [KO:K06548]
104681518  SPN; leukosialin [KO:K06477]
104660645  NECTIN3; nectin-3 isoform X5 [KO:K06592]
104653794  CLDN34; claudin-34 [KO:K06087]
104665597  CLDN11; claudin-11 isoform X1 [KO:K06087]
104679389  CLDN14; claudin-14 [KO:K06087]
104662295  CLDN18; claudin-18 isoform X1 [KO:K06087]
104663640  CLDN8; claudin-8 [KO:K06087]
104663641  CLDN17; claudin-17 [KO:K06087]
104672320  CLDN6; claudin-6 [KO:K06087]
104672321  CLDN9; claudin-9 [KO:K06087]
104673328  CLDN7; claudin-7 [KO:K06087]
104669410  CLDN25; putative claudin-25 [KO:K06087]
104670352  CLDN2; claudin-2 [KO:K06087]
104680050  CLDN16; claudin-16 [KO:K06087]
104680051  CLDN1; claudin-1 [KO:K06087]
104669006  CLDN19; claudin-19 isoform X1 [KO:K06087]
104673778  claudin-22 [KO:K06087]
104673779  CLDN24; putative claudin-24 [KO:K06087]
104654317  CLDN23; claudin-23 [KO:K06087]
104658806  CLDN10; claudin-10 isoform X1 [KO:K06087]
104656679  CLDN5; claudin-5 [KO:K06087]
104681189  CLDN15; claudin-15 [KO:K06087]
104681237  claudin-3 [KO:K06087]
104681238  claudin-4 [KO:K06087]
104657685  CLDN20; claudin-20 [KO:K06087]
104655252  CLDN12; claudin-12 [KO:K06087]
115899636  claudin-11-like [KO:K06087]
104675636  OCLN; occludin isoform X1 [KO:K06088]
104665325  F11R; junctional adhesion molecule A [KO:K06089]
104678200  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
104661422  JAM3; junctional adhesion molecule C [KO:K06785]
104679137  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
104655679  CDH5; cadherin-5 [KO:K06533]
104675445  PECAM1; platelet endothelial cell adhesion molecule isoform X5 [KO:K06471]
104667030  CD99; CD99 antigen isoform X1 [KO:K06520]
104663194  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
104661578  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
104660247  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
104660567  SELP; P-selectin isoform X1 [KO:K06496]
104666588  ITGA4; integrin alpha-4 [KO:K06483]
104663301  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
104672775  ITGA9; integrin alpha-9 [KO:K06585]
104673258  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
104670606  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
104681453  MADCAM1; mucosal addressin cell adhesion molecule 1 isoform X1 [KO:K06779]
104660582  SELL; L-selectin [KO:K06495]
104664175  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
104677856  GLG1; Golgi apparatus protein 1 [KO:K06816]
104660590  SELE; E-selectin [KO:K06494]
104657223  NECTIN1; nectin-1 [KO:K06081]
104676179  CDH2; cadherin-2 [KO:K06736]
104677367  NCAM1; neural cell adhesion molecule 1 isoform X9 [KO:K06491]
104658720  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
104661172  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
104668913  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
104656066  NEGR1; neuronal growth regulator 1 [KO:K06775]
104661270  NTNG1; netrin-G1 isoform X1 [KO:K07522]
104672777  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
104669755  NTNG2; netrin-G2 isoform X1 [KO:K16359]
104674422  LRRC4; leucine-rich repeat-containing protein 4 isoform X1 [KO:K16351]
104669035  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
104667234  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
104654307  SDC1; syndecan-1 [KO:K06257]
104671568  SDC2; syndecan-2 [KO:K16336]
104680924  SDC3; syndecan-3 isoform X1 [KO:K16337]
104678848  SDC4; syndecan-4 isoform X1 [KO:K16338]
104667754  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
104658643  ITGB8; integrin beta-8 [KO:K06591]
104664159  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
104673261  NRXN2; neurexin-2-beta isoform X1 [KO:K07377]
104676247  NLGN4X; neuroligin-4, X-linked [KO:K07378]
104666531  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
104673356  neuroligin-4, X-linked-like [KO:K07378]
104661638  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
104679124  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
104665478  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
104658560  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
104673066  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
104654401  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
104677262  SLITRK5; SLIT and NTRK-like protein 5 isoform X1 [KO:K25836]
104653833  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
104657264  PTPRD; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
104659027  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
104657036  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
104672366  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
104662446  CNTN1; contactin-1 isoform X1 [KO:K06759]
104670224  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
104664009  CNTN2; contactin-2 [KO:K06760]
104664008  NFASC; neurofascin isoform X1 [KO:K06757]
104680137  CNTNAP1; contactin-associated protein 1 [KO:K07379]
104667022  CNTNAP2; LOW QUALITY PROTEIN: contactin-associated protein-like 2 [KO:K07380]
104665349  MPZ; myelin protein P0 [KO:K06770]
104667110  MAG; myelin-associated glycoprotein [KO:K06771]
104655589  CDH1; LOW QUALITY PROTEIN: cadherin-1 [KO:K05689]
104679906  VCAN; versican core protein isoform X3 [KO:K06793]
104673514  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
115895183  cadherin-3-like [KO:K06796]
104655591  CDH3; cadherin-3 isoform X1 [KO:K06796]
104663814  CDH4; cadherin-4 [KO:K06797]
104662916  CDH15; cadherin-15 [KO:K06809]
104678067  NEO1; neogenin isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
rro04520  Adherens junction
rro04530  Tight junction
rro04610  Complement and coagulation cascades
rro04660  T cell receptor signaling pathway
rro04670  Leukocyte transendothelial migration
KO pathway
ko04514   
LinkDB

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