Entry
Name
Cardiac muscle contraction - Rissa tridactyla (black-legged kittiwake)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Rissa tridactyla (black-legged kittiwake) [GN:
rtd ]
Gene
128909658 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
128915456 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
128900329 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
128919387 CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
128906214 CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
128901260 CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864 ]
128912430 CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
128907306 CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
128915756 CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859 ]
128915514 CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860 ]
128914754 CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
128917763 CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
128918426 CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867 ]
128913848 CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
128917762 CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
128917979 CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
128917078 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
128919123 myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K12750 ]
128903803 LOW QUALITY PROTEIN: cytochrome c1, heme protein, mitochondrial [KO:K00413 ]
128908890 cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263 ]
128907157 cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270 ]
128911130 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540 ]
128911803 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
128918657 FXYD2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538 ]
Compound
Reference
Authors
Bers DM
Title
Calcium cycling and signaling in cardiac myocytes.
Journal
Reference
Authors
Bers DM
Title
Cardiac excitation-contraction coupling.
Journal
Reference
Authors
Endoh M
Title
Signal transduction and Ca2+ signaling in intact myocardium.
Journal
Reference
Authors
Endoh M
Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
Journal
Reference
Authors
Bers DM, Despa S
Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
Journal
Reference
Authors
Gordon AM, Homsher E, Regnier M
Title
Regulation of contraction in striated muscle.
Journal
Reference
Authors
Phrommintikul A, Chattipakorn N
Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
Journal
Reference
Authors
Lacinova L
Title
Voltage-dependent calcium channels.
Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
Journal
Reference
Authors
Berg JS, Powell BC, Cheney RE
Title
A millennial myosin census.
Journal
Reference
Authors
Parmacek MS, Solaro RJ
Title
Biology of the troponin complex in cardiac myocytes.
Journal
Reference
Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Journal
Reference
Authors
Pritchard TJ, Kranias EG
Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
Journal
Reference
Authors
Landstrom AP, Dobrev D, Wehrens XHT
Title
Calcium Signaling and Cardiac Arrhythmias.
Journal
Related pathway
KO pathway
LinkDB
All DBs