KEGG   PATHWAY: rvl00270
Entry
rvl00270                    Pathway                                
Name
Cysteine and methionine metabolism - Rhododendron vialii
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
rvl00270  Cysteine and methionine metabolism
rvl00270

Module
rvl_M00021  Cysteine biosynthesis, serine => cysteine [PATH:rvl00270]
rvl_M00034  Methionine salvage pathway [PATH:rvl00270]
rvl_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:rvl00270]
Other DBs
GO: 0006534 0006555
Organism
Rhododendron vialii [GN:rvl]
Gene
131304063  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
131335955  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
131322356  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
131312857  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
131325237  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
131325239  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
131325247  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
131325248  putative inactive cysteine synthase 2 isoform X1 [KO:K01738] [EC:2.5.1.47]
131325249  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
131325250  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
131329660  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
131300673  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
131333122  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
131319154  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
131333777  homocysteine S-methyltransferase 2 [KO:K00547] [EC:2.1.1.10]
131310794  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
131315884  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
131318484  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
131321079  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1-like [KO:K00549] [EC:2.1.1.14]
131312479  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
131320991  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
131308688  S-adenosylmethionine synthase 5-like [KO:K00789] [EC:2.5.1.6]
131325475  S-adenosylmethionine synthase 3-like isoform X1 [KO:K00789] [EC:2.5.1.6]
131327296  S-adenosylmethionine synthase 3-like isoform X1 [KO:K00789] [EC:2.5.1.6]
131314899  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
131304578  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
131322476  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
131310475  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
131325437  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
131298978  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
131319746  spermine synthase [KO:K00797] [EC:2.5.1.16]
131310288  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
131307468  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
131308022  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like isoform X1 [KO:K01244] [EC:3.2.2.16]
131308023  5'-methylthioadenosine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
131308027  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
131325098  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like isoform X1 [KO:K01244] [EC:3.2.2.16]
131308762  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
131308763  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
131325299  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
131323355  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
131329853  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
131324247  acireductone dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
131324248  acireductone dioxygenase 1-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
131307536  uncharacterized protein LOC131307536 [KO:K23977] [EC:2.6.1.117]
131323362  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
131324882  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
131324883  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
131329096  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
131309799  aromatic aminotransferase ISS1 isoform X1 [KO:K00837] [EC:2.6.1.-]
131329027  aromatic aminotransferase ISS1-like isoform X1 [KO:K00837] [EC:2.6.1.-]
131316446  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
131306359  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
131306629  DNA (cytosine-5)-methyltransferase CMT2-like isoform X1 [KO:K00558] [EC:2.1.1.37]
131326000  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
131300244  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
131300258  DNA (cytosine-5)-methyltransferase CMT3-like isoform X1 [KO:K00558] [EC:2.1.1.37]
131300453  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
131327311  PWWP domain-containing protein 1-like isoform X1 [KO:K17398] [EC:2.1.1.37]
131332268  PWWP domain-containing protein 1-like [KO:K17398] [EC:2.1.1.37]
131316114  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
131334640  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
131314874  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
131303913  1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
131325805  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
131332012  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
131320081  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
131307282  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
131307307  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
131330728  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
131330729  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
131330730  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
131315228  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
131311406  aspartokinase 2, chloroplastic [KO:K00928] [EC:2.7.2.4]
131298445  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
131320895  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
131326290  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
131301731  uncharacterized protein LOC131301731 [KO:K00133] [EC:1.2.1.11]
131335105  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
131302294  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
131304088  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
131329872  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
131332481  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
131303901  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
131326129  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
131315641  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
131315642  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
131334641  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
131315564  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
131330056  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
131331836  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
131322262  uncharacterized protein LOC131322262 isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
131329321  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
131332827  L-lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
131336167  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
131310004  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
131308733  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
131327425  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
131315513  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
131331767  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
131331768  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
131304207  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
131307258  malate dehydrogenase, glyoxysomal isoform X1 [KO:K00026] [EC:1.1.1.37]
131323386  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
131325985  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
131331547  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
131319270  cysteine synthase isoform X1 [KO:K22846] [EC:2.5.1.144]
131309728  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
131327962  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
131331255  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
131303658  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
rvl00010  Glycolysis / Gluconeogenesis
rvl00250  Alanine, aspartate and glutamate metabolism
rvl00260  Glycine, serine and threonine metabolism
rvl00290  Valine, leucine and isoleucine biosynthesis
rvl00430  Taurine and hypotaurine metabolism
rvl00480  Glutathione metabolism
rvl00620  Pyruvate metabolism
rvl00640  Propanoate metabolism
rvl00770  Pantothenate and CoA biosynthesis
rvl00900  Terpenoid backbone biosynthesis
rvl00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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