KEGG   PATHWAY: sanh03320
Entry
sanh03320                   Pathway                                
Name
PPAR signaling pathway - Sinocyclocheilus anshuiensis
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
sanh03320  PPAR signaling pathway
sanh03320

Organism
Sinocyclocheilus anshuiensis [GN:sanh]
Gene
107694198  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
107680017  platelet glycoprotein 4-like [KO:K06259]
107672489  long-chain fatty acid transport protein 1-like [KO:K08745] [EC:6.2.1.-]
107658662  long-chain fatty acid transport protein 4-like [KO:K08745] [EC:6.2.1.-]
107662711  long-chain fatty acid transport protein 1-like [KO:K08745] [EC:6.2.1.-]
107670527  long-chain fatty acid transport protein 1-like [KO:K08745] [EC:6.2.1.-]
107685116  long-chain fatty acid transport protein 4-like [KO:K08745] [EC:6.2.1.-]
107662448  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107662449  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107688935  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107688936  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107703947  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107669786  long-chain fatty acid transport protein 6-like [KO:K08749]
107669787  long-chain fatty acid transport protein 6-like [KO:K08749]
107704576  fatty acid binding protein 1-B.1 [KO:K08750]
107674923  fabp1; fatty acid-binding protein, liver [KO:K08750]
107661522  fatty acid binding protein 1-B.1-like [KO:K08750]
107700317  fatty acid-binding protein, intestinal-like [KO:K08751]
107695844  fatty acid-binding protein, intestinal-like [KO:K08751]
107702112  fatty acid-binding protein, adipocyte-like [KO:K08752]
107696578  fatty acid-binding protein, heart-like [KO:K08752]
107669374  fatty acid-binding protein, heart-like [KO:K08752]
107696199  fatty acid-binding protein, heart-like [KO:K08752]
107685598  fatty acid-binding protein, adipocyte-like [KO:K08753]
107673018  fatty acid-binding protein, adipocyte-like [KO:K08753]
107673806  gastrotropin-like [KO:K08755]
107684737  gastrotropin-like [KO:K08755]
107682495  fatty acid-binding protein, brain-like [KO:K08756]
107675046  fatty acid-binding protein, brain-like [KO:K08756]
107675216  fatty acid-binding protein, brain-like [KO:K08756]
107693085  fatty acid-binding protein, brain-like [KO:K08756]
107664866  peroxisome proliferator-activated receptor alpha-like isoform X1 [KO:K07294]
107701195  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
107695898  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
107668648  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
107686886  retinoic acid receptor RXR-alpha-A [KO:K08524]
107679846  retinoic acid receptor RXR-alpha-A-like [KO:K08524]
107672569  retinoic acid receptor RXR-alpha-B-like [KO:K08524]
107693746  retinoic acid receptor RXR-gamma-A-like isoform X1 [KO:K08524]
107660328  retinoic acid receptor RXR-alpha-B isoform X1 [KO:K08524]
107677771  retinoic acid receptor RXR-gamma-A isoform X1 [KO:K08524]
107694777  retinoic acid receptor RXR-beta-A isoform X1 [KO:K08525]
107694154  retinoic acid receptor RXR-beta-A-like [KO:K08525]
107698299  peroxisome proliferator-activated receptor delta-like [KO:K04504]
107668057  peroxisome proliferator-activated receptor delta-like [KO:K04504]
107667629  peroxisome proliferator-activated receptor delta-like [KO:K04504]
107678785  peroxisome proliferator-activated receptor delta-like [KO:K04504]
107687310  pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
107667870  peroxisome proliferator-activated receptor gamma-like [KO:K08530]
107702579  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [KO:K01641] [EC:2.3.3.10]
107670031  hydroxymethylglutaryl-CoA synthase, cytoplasmic-like [KO:K01641] [EC:2.3.3.10]
107663743  apolipoprotein A-I-1-like [KO:K08757]
107661262  apolipoprotein A-I [KO:K08757]
107663408  apolipoprotein A-I-like [KO:K08757]
107688065  apolipoprotein A-I-1-like isoform X1 [KO:K08757]
107688286  type-4 ice-structuring protein LS-12-like [KO:K08758]
107688287  type-4 ice-structuring protein LS-12-like [KO:K08758]
107671415  type-4 ice-structuring protein LS-12-like [KO:K08758]
107671385  type-4 ice-structuring protein LS-12-like [KO:K08758]
107696437  phospholipid transfer protein-like [KO:K08761]
107666176  phospholipid transfer protein-like [KO:K08761]
107704946  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
107700750  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
107695468  NADP-dependent malic enzyme, mitochondrial-like isoform X1 [KO:K00029] [EC:1.1.1.40]
107673657  NADP-dependent malic enzyme, mitochondrial-like [KO:K00029] [EC:1.1.1.40]
107674834  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
107655157  fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
107688042  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
107673932  acyl-CoA desaturase-like isoform X1 [KO:K00507] [EC:1.14.19.1]
107659656  acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
107698673  cholesterol 7-alpha-monooxygenase isoform X1 [KO:K00489] [EC:1.14.14.23]
107693703  cholesterol 7-alpha-monooxygenase-like [KO:K00489] [EC:1.14.14.23]
107691428  cholesterol 7-alpha-monooxygenase-like [KO:K00489] [EC:1.14.14.23]
107661909  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
107671665  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
107689968  oxysterols receptor LXR-alpha-like isoform X1 [KO:K08536]
107664377  oxysterols receptor LXR-alpha-like [KO:K08536]
107658292  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
107677609  cytochrome P450 27C1-like [KO:K00488] [EC:1.14.15.15]
107683415  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
107660625  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
107660626  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
107659991  cytochrome P450 27C1-like [KO:K00488] [EC:1.14.15.15]
107670303  dbi; acyl-CoA-binding protein [KO:K08762]
107696683  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
107687910  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
107665504  lipoprotein lipase-like isoform X1 [KO:K01059] [EC:3.1.1.34]
107665505  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
107653621  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
107657193  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
107678403  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
107702334  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
107679387  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
107665192  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
107687654  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
107702457  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
107678619  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
107680372  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
107668460  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
107660143  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
107684041  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
107656816  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
107666599  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
107670181  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
107695249  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
107703272  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
107698217  long-chain-fatty-acid--CoA ligase ACSBG1-like isoform X1 [KO:K15013] [EC:6.2.1.3]
107699749  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
107659501  long-chain-fatty-acid--CoA ligase ACSBG1-like [KO:K15013] [EC:6.2.1.3]
107676759  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
107663901  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
107670419  3-ketoacyl-CoA thiolase B, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
107701655  3-ketoacyl-CoA thiolase A, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
107681719  scp2; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
107661972  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
107660714  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
107702990  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
107671150  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
107686536  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
107667163  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
107677167  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
107688557  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
107675280  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
107689673  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
107696638  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
107694092  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
107695271  carnitine O-palmitoyltransferase 2, mitochondrial-like [KO:K08766] [EC:2.3.1.21]
107668114  carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
107700586  acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00255] [EC:1.3.8.8]
107674066  medium-chain specific acyl-CoA dehydrogenase, mitochondrial-like [KO:K00249] [EC:1.3.8.7]
107688505  medium-chain specific acyl-CoA dehydrogenase, mitochondrial-like [KO:K00249] [EC:1.3.8.7]
107688469  angiopoietin-related protein 4-like [KO:K08767]
107680254  angiopoietin-related protein 4-like isoform X1 [KO:K08767]
107666363  sorbin and SH3 domain-containing protein 1-like [KO:K06086]
107693022  plin1; perilipin-1 [KO:K08768]
107701433  perilipin-2-like [KO:K17284]
107681756  adiponectin-like [KO:K07296]
107685469  adiponectin-like [KO:K07296]
107685015  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
107701121  ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
107674683  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107703375  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107677174  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
107667172  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
107657833  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
107703124  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
107691411  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
107700103  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
107667651  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
107661734  aquaporin-7-like [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
sanh00071  Fatty acid degradation
sanh00120  Primary bile acid biosynthesis
sanh00564  Glycerophospholipid metabolism
sanh04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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