KEGG   PATHWAY: schu00270
Entry
schu00270                   Pathway                                
Name
Cysteine and methionine metabolism - Siniperca chuatsi (mandarin fish)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
schu00270  Cysteine and methionine metabolism
schu00270

Module
schu_M00034  Methionine salvage pathway [PATH:schu00270]
schu_M00035  Methionine degradation [PATH:schu00270]
schu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:schu00270]
Other DBs
GO: 0006534 0006555
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122878378  cystathionine gamma-lyase-like isoform X1 [KO:K01758] [EC:4.4.1.1]
122877274  kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
122866171  kyat1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
122871764  cbsa; cystathionine beta-synthase a isoform X1 [KO:K01697] [EC:4.2.1.22]
122885471  cbsb; LOW QUALITY PROTEIN: cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
122876422  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
122876937  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
122876938  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
122865754  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
122877605  zgc:172121; homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
122867849  mtr; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
122868218  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
122887863  mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
122876722  mat2ab; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
122884190  mat1a; S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
122865830  mat2al; methionine adenosyltransferase II, alpha-like isoform X1 [KO:K00789] [EC:2.5.1.6]
122866040  mat2aa; methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]
122862857  amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
122883183  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
122883248  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
122888489  sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
122872951  S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
122885142  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
122873941  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
122876263  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
122865889  enoph1; enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
122861683  adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase isoform X1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122874450  tat; tyrosine aminotransferase isoform X1 [KO:K00815] [EC:2.6.1.5]
122870147  L-amino-acid oxidase-like isoform X1 [KO:K03334] [EC:1.4.3.2]
122870148  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
122879528  il4i1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
122861874  gnmt; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
122868564  dnmt1; DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
122862743  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
122861418  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
122882624  uncharacterized protein LOC122882624 isoform X1 [KO:K17399] [EC:2.1.1.37]
122882616  dnmt3bb.1; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
122882863  dnmt3ba; DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1 [KO:K17399] [EC:2.1.1.37]
122882428  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
122882936  ahcyl1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
122871058  ahcyl2b; adenosylhomocysteinase like 2b isoform X1 [KO:K01251] [EC:3.13.2.1]
122886573  S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]
122874705  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
122869181  bcat2; branched-chain-amino-acid aminotransferase, mitochondrial isoform X1 [KO:K00826] [EC:2.6.1.42]
122871251  bcat1; branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]
122865331  alanine--glyoxylate aminotransferase 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122865333  alanine--glyoxylate aminotransferase 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122884427  gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
122877515  gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]
122882677  gss; glutathione synthetase isoform X1 [KO:K21456] [EC:6.3.2.3]
122876932  cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
122876180  got1l1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
122883978  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122873532  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
122876584  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
122871618  mpst; 3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
122871188  ldhba; L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]
122874753  ldhbb; L-lactate dehydrogenase B-B chain isoform X1 [KO:K00016] [EC:1.1.1.27]
122875108  ldha; L-lactate dehydrogenase A chain isoform X1 [KO:K00016] [EC:1.1.1.27]
122884164  mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
122873126  LOW QUALITY PROTEIN: malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
122881053  mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
122876656  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122861692  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122885922  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122876346  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
schu00010  Glycolysis / Gluconeogenesis
schu00250  Alanine, aspartate and glutamate metabolism
schu00260  Glycine, serine and threonine metabolism
schu00290  Valine, leucine and isoleucine biosynthesis
schu00430  Taurine and hypotaurine metabolism
schu00480  Glutathione metabolism
schu00620  Pyruvate metabolism
schu00640  Propanoate metabolism
schu00770  Pantothenate and CoA biosynthesis
schu00900  Terpenoid backbone biosynthesis
schu00920  Sulfur metabolism
KO pathway
ko00270   
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