KEGG   PATHWAY: sclv04146
Entry
sclv04146                   Pathway                                
Name
Peroxisome - Styela clava (leathery sea squirt)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
sclv04146  Peroxisome
sclv04146

Other DBs
GO: 0005777
Organism
Styela clava (leathery sea squirt) [GN:sclv]
Gene
120341850  peroxisomal membrane protein PEX16-like [KO:K13335]
120341434  LOW QUALITY PROTEIN: peroxisomal biogenesis factor 3-like [KO:K13336]
120332716  peroxisomal biogenesis factor 19-like [KO:K13337]
120332433  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
120333960  peroxisome biogenesis factor 1-like [KO:K13338]
120330779  peroxisome assembly factor 2-like [KO:K13339]
120334971  peroxisomal targeting signal 2 receptor-like [KO:K13341]
120327725  peroxisomal targeting signal 1 receptor-like [KO:K13342]
120328543  peroxisomal membrane protein PEX14-like isoform X1 [KO:K13343]
120329419  peroxisomal membrane protein PEX13-like [KO:K13344]
120330475  LOW QUALITY PROTEIN: peroxisome assembly protein 12-like [KO:K13345]
120345273  peroxisome biogenesis factor 10-like [KO:K13346]
120347771  peroxisome biogenesis factor 2-like [KO:K06664]
120334800  peroxisomal membrane protein 2-like [KO:K13347]
120334802  peroxisomal membrane protein 2-like [KO:K13347]
120329389  mpv17-like protein 2 [KO:K13348]
120330884  protein Mpv17-like isoform X1 [KO:K13348]
120331658  protein Mpv17-like [KO:K13348]
120328717  peroxisomal membrane protein 4-like [KO:K13350]
120346161  peroxisomal membrane protein 11A-like [KO:K13352]
120341709  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
120335147  alpha-methylacyl-CoA racemase-like isoform X1 [KO:K01796] [EC:5.1.99.4]
120335153  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
120327023  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
120337900  probable alpha-ketoglutarate-dependent hypophosphite dioxygenase [KO:K00477] [EC:1.14.11.18]
120339602  phytanoyl-CoA dioxygenase, peroxisomal-like isoform X1 [KO:K00477] [EC:1.14.11.18]
120339603  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
120344988  acyl-coenzyme A oxidase 3, peroxisomal-like [KO:K00232] [EC:1.3.3.6]
120345543  acyl-coenzyme A oxidase 3, peroxisomal-like [KO:K00232] [EC:1.3.3.6]
120346336  acyl-coenzyme A oxidase 3, peroxisomal-like [KO:K00232] [EC:1.3.3.6]
120342778  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
120340587  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K10214] [EC:1.17.99.3]
120338122  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
120337099  non-specific lipid-transfer protein-like isoform X1 [KO:K08764] [EC:2.3.1.176]
120337215  non-specific lipid-transfer protein-like isoform X1 [KO:K08764] [EC:2.3.1.176]
120343818  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120343819  bile acid-CoA:amino acid N-acyltransferase-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120344834  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120337556  acyl-coenzyme A amino acid N-acyltransferase 2-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120329571  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120329639  bile acid-CoA:amino acid N-acyltransferase-like isoform X1 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120347055  acyl-coenzyme A amino acid N-acyltransferase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120348310  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120325725  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
120345665  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
120345918  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
120326758  peroxisomal 2,4-dienoyl-CoA reductase-like [KO:K13237] [EC:1.3.1.124]
120342156  peroxisomal 2,4-dienoyl-CoA reductase-like isoform X1 [KO:K13237] [EC:1.3.1.124]
120343108  peroxisomal 2,4-dienoyl-CoA reductase-like [KO:K13237] [EC:1.3.1.124]
120345418  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like isoform X1 [KO:K12663] [EC:5.3.3.21]
120345420  LOW QUALITY PROTEIN: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
120335857  ATP-binding cassette sub-family D member 1-like [KO:K05676] [EC:7.6.2.4]
120325953  lysosomal cobalamin transporter ABCD4-like [KO:K05678] [EC:7.6.2.8]
120337789  very long-chain acyl-CoA synthetase-like isoform X1 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
120343263  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
120335959  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
120336132  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
120348189  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
120342481  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
120344818  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
120344827  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
120329262  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
120329715  enoyl-CoA delta isomerase 2-like [KO:K13239] [EC:5.3.3.8]
120347605  uncharacterized Nudix hydrolase NudL-like [KO:K17879] [EC:3.6.1.77]
120342719  NAD-capped RNA hydrolase NUDT12-like [KO:K03426] [EC:3.6.1.22]
120333616  nucleoside diphosphate-linked moiety X motif 19-like [KO:K13355] [EC:3.6.1.77]
120329560  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
120343210  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
120343215  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
120338901  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
120329686  malonyl-CoA decarboxylase, mitochondrial-like [KO:K01578] [EC:4.1.1.9]
120346752  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
120326378  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
120345404  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
120342697  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
120327283  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
120332341  phosphomevalonate kinase-like [KO:K13273] [EC:2.7.4.2]
120328054  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
120347197  D-aspartate oxidase-like isoform X1 [KO:K00272] [EC:1.4.3.1]
120347338  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
120332563  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
120326682  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
120329359  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
120326890  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
120347425  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
120344623  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
120334549  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
120326420  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120335068  hydroxyacid oxidase 2-like [KO:K11517] [EC:1.1.3.15]
120327004  hydroxyacid oxidase 1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
120336323  hydroxyacid oxidase 1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
120336357  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120345681  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120345682  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120337530  hydroxyacid oxidase 1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
120330287  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120338861  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120347198  hydroxyacid oxidase 1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
120347199  hydroxyacid oxidase 1-like isoform X1 [KO:K11517] [EC:1.1.3.15]
120347202  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120347339  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120347340  LOW QUALITY PROTEIN: hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120339176  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120347954  LOW QUALITY PROTEIN: hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120340374  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120340701  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120341375  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
120331413  catalase-like [KO:K03781] [EC:1.11.1.6]
120336227  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
120338131  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
120338142  superoxide dismutase [Cu-Zn] 2-like [KO:K04565] [EC:1.15.1.1]
120338529  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
120337255  peroxiredoxin-like [KO:K13279] [EC:1.11.1.24]
120337441  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
120337631  bifunctional epoxide hydrolase 2-like [KO:K08726] [EC:3.3.2.10 3.1.3.76]
120330727  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
120332535  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
120332536  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
120343470  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120338173  abscisic-aldehyde oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120340015  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120342206  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120342361  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120342964  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120345446  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
120329237  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
120329238  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
120329239  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
120329240  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
120329241  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
120338305  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
120329789  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
120341287  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
120333271  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
sclv00071  Fatty acid degradation
sclv00230  Purine metabolism
sclv00564  Glycerophospholipid metabolism
sclv00565  Ether lipid metabolism
sclv00830  Retinol metabolism
sclv00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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