KEGG   PATHWAY: setr00350
Entry
setr00350                   Pathway                                
Name
Tyrosine metabolism - Suncus etruscus (white-toothed pygmy shrew)
Class
Metabolism; Amino acid metabolism
Pathway map
setr00350  Tyrosine metabolism
setr00350

Module
setr_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:setr00350]
setr_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:setr00350]
setr_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:setr00350]
Other DBs
GO: 0006570
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125994772  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
126007251  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
126022095  LOW QUALITY PROTEIN: aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
126027151  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
126027393  TAT; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
126028622  IL4I1; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
126000761  HPD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
126026204  HGD; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
126004082  GSTZ1; maleylacetoacetate isomerase isoform X1 [KO:K01800] [EC:5.2.1.2]
126022696  FAH; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
126019139  TYR; tyrosinase [KO:K00505] [EC:1.14.18.1]
126019057  TH; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
126016000  DCT; L-dopachrome tautomerase [KO:K01827] [EC:5.3.3.12]
126003983  TYRP1; 5,6-dihydroxyindole-2-carboxylic acid oxidase [KO:K00506] [EC:1.14.18.-]
126014154  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
126009332  DBH; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
125998732  PNMT; phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
125995103  COMT; catechol O-methyltransferase [KO:K00545] [EC:2.1.1.6]
126018336  TOMT; transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
125999202  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125999206  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
126017145  LOW QUALITY PROTEIN: retina-specific copper amine oxidase-like [KO:K00276] [EC:1.4.3.21]
126013702  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
126018797  aldehyde dehydrogenase family 3 member B2-like [KO:K00129] [EC:1.2.1.5]
126019060  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
126025489  ADH1C; alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
126025491  all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
126025507  all-trans-retinol dehydrogenase [NAD(+)] ADH4-like [KO:K13980] [EC:1.1.1.1]
126025979  all-trans-retinol dehydrogenase [NAD(+)] ADH4-like [KO:K13980] [EC:1.1.1.1]
126025488  ADH5; alcohol dehydrogenase class-3 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
126032540  LOW QUALITY PROTEIN: alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
126024250  TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
126008678  aldehyde oxidase 2-like [KO:K00157] [EC:1.2.3.1]
126008679  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
126009003  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
126000914  FAHD1; acylpyruvase FAHD1, mitochondrial [KO:K01557] [EC:3.7.1.5]
126022832  LOW QUALITY PROTEIN: macrophage migration inhibitory factor-like [KO:K07253] [EC:5.3.2.1]
126033753  MIF; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
setr00020  Citrate cycle (TCA cycle)
setr00360  Phenylalanine metabolism
setr00400  Phenylalanine, tyrosine and tryptophan biosynthesis
setr00620  Pyruvate metabolism
setr00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

DBGET integrated database retrieval system