KEGG PATHWAY: sgh04216

KEGG

PATHWAY: sgh04216

Entry

sgh04216                    Pathway

Name

Ferroptosis - Sinocyclocheilus grahami (golden-line barbel)

Description

Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.

Class

Cellular Processes; Cell growth and death

Pathway map

Ferroptosis

Other DBs

GO:

Organism

Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]

Gene

4F2 cell-surface antigen heavy chain-like [KO:K06519]

4F2 cell-surface antigen heavy chain-like [KO:K06519]

4F2 cell-surface antigen heavy chain-like [KO:K06519]

4F2 cell-surface antigen heavy chain-like [KO:K06519]

4F2 cell-surface antigen heavy chain-like [KO:K06519]

cystine/glutamate transporter-like [KO:K13869]

cystine/glutamate transporter-like [KO:K13869]

cystine/glutamate transporter-like [KO:K13869]

cystine/glutamate transporter-like [KO:K13869]

cellular tumor antigen p53-like isoform X1 [KO:K04451]

cellular tumor antigen p53 isoform X1 [KO:K04451]

glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]

gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]

glutamate--cysteine ligase regulatory subunit-like [KO:K11205]

glutamate--cysteine ligase regulatory subunit-like [KO:K11205]

gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]

glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]

phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like isoform X1 [KO:K05361] [EC:1.11.1.12]

long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]

acsl1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]

acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]

long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]

lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]

lysophospholipid acyltransferase 5-like isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]

diamine acetyltransferase 2-like [KO:K00657] [EC:2.3.1.57]

diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]

diamine acetyltransferase 1-like isoform X1 [KO:K00657] [EC:2.3.1.57]

diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]

diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]

diamine acetyltransferase 2-like [KO:K00657] [EC:2.3.1.57]

diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]

sat2; diamine acetyltransferase 2 [KO:K00657] [EC:2.3.1.57]

diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]

serotransferrin-1-like [KO:K14736]

transferrin receptor protein 1-like isoform X1 [KO:K06503]

transferrin receptor protein 1-like [KO:K06503]

transferrin receptor protein 1-like [KO:K06503]

transferrin receptor protein 1-like isoform X1 [KO:K06503]

metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]

natural resistance-associated macrophage protein 2-like isoform X1 [KO:K21398]

natural resistance-associated macrophage protein 2-like [KO:K21398]

zinc transporter ZIP8-like [KO:K14714]

zinc transporter ZIP8-like [KO:K14714]

LOW QUALITY PROTEIN: zinc transporter ZIP8-like [KO:K14714]

zinc transporter ZIP14-like isoform X1 [KO:K14720]

zinc transporter ZIP14-like isoform X1 [KO:K14720]

pcbp2; poly(rC)-binding protein 2 [KO:K13162]

poly(rC)-binding protein 2 [KO:K13162]

solute carrier family 40 member 1-like [KO:K14685]

solute carrier family 40 member 1 [KO:K14685]

solute carrier family 40 member 1-like [KO:K14685]

solute carrier family 40 member 1-like [KO:K14685]

LOW QUALITY PROTEIN: ceruloplasmin-like [KO:K13624] [EC:1.16.3.1]

cp; ceruloplasmin [KO:K13624] [EC:1.16.3.1]

ferritin, heavy subunit isoform X1 [KO:K00522] [EC:1.16.3.1]

ferritin, middle subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]

ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]

ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]

ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]

ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]

ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]

ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]

ferritin, middle subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]

ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]

ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]

microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]

microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]

microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]

microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]

microtubule-associated proteins 1A/1B light chain 3A-like [KO:K10435]

microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]

microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]

map1lc3c; microtubule-associated proteins 1A/1B light chain 3C isoform X1 [KO:K10435]

autophagy protein 5-like [KO:K08339]

atg5; autophagy protein 5 [KO:K08339]

atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]

nuclear receptor coactivator 4-like [KO:K09289]

ncoa4; nuclear receptor coactivator 4 [KO:K09289]

heme oxygenase-like [KO:K00510] [EC:1.14.14.18]

heme oxygenase-like [KO:K00510] [EC:1.14.14.18]

heme oxygenase-like [KO:K00510] [EC:1.14.14.18]

voltage-dependent anion-selective channel protein 2-like [KO:K15040]

voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]

voltage-dependent anion-selective channel protein 2-like [KO:K15040]

voltage-dependent anion-selective channel protein 2-like [KO:K15041]

voltage-dependent anion-selective channel protein 2-like [KO:K15041]

voltage-dependent anion-selective channel protein 2-like [KO:K15041]

cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]

cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]

Compound

CoA

Acetyl-CoA

L-Glutamate

Hydrogen peroxide

Heme

Glutathione

L-Cysteine

Glutathione disulfide

Isopentenyl diphosphate

Arachidonate

(S)-3-Hydroxy-3-methylglutaryl-CoA

(R)-Mevalonate

L-Cystine

gamma-L-Glutamyl-L-cysteine

Arachidonyl-CoA

alpha-Tocopherol

Ubiquinone-10

Fe2+

Fe3+

(7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA

Adrenic acid

Hydroxyl radical

Erastin

RSL3

1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

1-Octadecanoyl-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycero-3-phosphoethanolamine

1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

1-Octadecanoyl-sn-glycero-3-phosphoethanolamine

Sulfasalazine (USP/INN)

Sorafenib (USAN/INN)

Reference

Authors

Conrad M, Angeli JP, Vandenabeele P, Stockwell BR

Title

Regulated necrosis: disease relevance and therapeutic opportunities.

Journal

Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6

Reference

Authors

Yang WS, Stockwell BR

Title

Ferroptosis: Death by Lipid Peroxidation.

Journal

Trends Cell Biol 26:165-76 (2016)
DOI:10.1016/j.tcb.2015.10.014

Reference

Authors

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H

Title

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Journal

Nat Chem Biol 13:81-90 (2017)
DOI:10.1038/nchembio.2238

Reference

Authors

D'Herde K, Krysko DV

Title

Ferroptosis: Oxidized PEs trigger death.

Journal

Nat Chem Biol 13:4-5 (2017)
DOI:10.1038/nchembio.2261

Reference

Authors

Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S

Title

Ferroptosis and cell death mechanisms in Parkinson's disease.

Journal

Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004

Reference

Authors

Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y

Title

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.

Journal

Trends Biochem Sci 41:274-86 (2016)
DOI:10.1016/j.tibs.2015.11.012

Reference

Authors

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D

Title

Ferroptosis: process and function.

Journal

Cell Death Differ 23:369-79 (2016)
DOI:10.1038/cdd.2015.158

Reference

Authors

Murphy ME

Title

Ironing out how p53 regulates ferroptosis.

Journal

Proc Natl Acad Sci U S A 113:12350-12352 (2016)
DOI:10.1073/pnas.1615159113

Reference

Authors

Muckenthaler MU, Rivella S, Hentze MW, Galy B

Title

A Red Carpet for Iron Metabolism.

Journal

Cell 168:344-361 (2017)
DOI:10.1016/j.cell.2016.12.034

Reference

Authors

Yu H, Guo P, Xie X, Wang Y, Chen G

Title

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.

Journal

J Cell Mol Med 21:648-657 (2017)
DOI:10.1111/jcmm.13008

Reference

Authors

Wang SJ, Ou Y, Jiang L, Gu W

Title

Ferroptosis: A missing puzzle piece in the p53 blueprint?

Journal

Mol Cell Oncol 3:e1046581 (2016)
DOI:10.1080/23723556.2015.1046581

Reference

Authors

Cao JY, Dixon SJ

Title

Mechanisms of ferroptosis.

Journal

Cell Mol Life Sci 73:2195-209 (2016)
DOI:10.1007/s00018-016-2194-1

Reference

Authors

Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW

Title

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

Journal

Elife 4:e10308 (2015)
DOI:10.7554/eLife.10308

Reference

Authors

Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ

Title

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.

Journal

Front Aging Neurosci 8:308 (2016)
DOI:10.3389/fnagi.2016.00308

Reference

Authors

Kwon MY, Park E, Lee SJ, Chung SW

Title

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.

Journal

Oncotarget 6:24393-403 (2015)
DOI:10.18632/oncotarget.5162

Reference

Authors

Reed JC, Pellecchia M

Title

Ironing out cell death mechanisms.

Journal

Cell 149:963-5 (2012)
DOI:10.1016/j.cell.2012.05.009

Related
pathway

Glutathione metabolism

Terpenoid backbone biosynthesis

KO pathway

LinkDB

DBGET integrated database retrieval system