KEGG   PATHWAY: shon00260
Entry
shon00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Sturnira hondurensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
shon00260  Glycine, serine and threonine metabolism
shon00260

Module
shon_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:shon00260]
shon_M00047  Creatine pathway [PATH:shon00260]
shon_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:shon00260]
shon_M00555  Betaine biosynthesis, choline => betaine [PATH:shon00260]
shon_M00621  Glycine cleavage system [PATH:shon00260]
shon_M00974  Betaine metabolism, animals, betaine => glycine [PATH:shon00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Sturnira hondurensis [GN:shon]
Gene
118975922  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
119002709  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
119003113  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
118979617  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
118993368  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
118990284  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
118983456  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
118989129  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
118981934  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
118983185  LOW QUALITY PROTEIN: phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
118976062  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
118976262  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
119002320  GCAT; LOW QUALITY PROTEIN: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
118984621  LOW QUALITY PROTEIN: L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
118989413  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
118981782  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
118994607  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
118994608  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
118978201  AOC3; LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
118978202  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
118997642  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
118989477  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
119003976  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
118981197  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
118991215  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
118998768  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
118992582  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
118984405  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
118983347  CHDH; choline dehydrogenase, mitochondrial isoform X1 [KO:K00108] [EC:1.1.99.1]
118974985  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118977292  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
118977291  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
119003608  PIPOX; LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
118980108  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
118991685  GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
118984864  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
118984481  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
118991133  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
118991135  SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
119003790  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
shon00010  Glycolysis / Gluconeogenesis
shon00020  Citrate cycle (TCA cycle)
shon00230  Purine metabolism
shon00250  Alanine, aspartate and glutamate metabolism
shon00270  Cysteine and methionine metabolism
shon00290  Valine, leucine and isoleucine biosynthesis
shon00300  Lysine biosynthesis
shon00330  Arginine and proline metabolism
shon00470  D-Amino acid metabolism
shon00564  Glycerophospholipid metabolism
shon00600  Sphingolipid metabolism
shon00620  Pyruvate metabolism
shon00630  Glyoxylate and dicarboxylate metabolism
shon00640  Propanoate metabolism
shon00860  Porphyrin metabolism
shon00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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