KEGG   PATHWAY: smi00230
Entry
smi00230                    Pathway                                
Name
Purine metabolism - Sinorhizobium meliloti Rm41
Class
Metabolism; Nucleotide metabolism
Pathway map
smi00230  Purine metabolism
smi00230

Module
smi_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:smi00230]
smi_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:smi00230]
smi_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:smi00230]
smi_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:smi00230]
smi_M00546  Purine degradation, xanthine => urea [PATH:smi00230]
smi_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:smi00230]
smi_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:smi00230]
Other DBs
GO: 0006163 0042278
Organism
Sinorhizobium meliloti Rm41 [GN:smi]
Gene
BN406_03267  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
BN406_02703  pgm; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
BN406_02198  prs; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
BN406_00860  purF; Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
BN406_00512  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
BN406_00917  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
BN406_01511  purL; phosphoribosylformylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
BN406_01506  phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264] [EC:6.3.5.3]
BN406_01507  purQ; phosphoribosylformylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
BN406_00918  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
BN406_02644  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
BN406_02643  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit protein [KO:K01588] [EC:5.4.99.18]
BN406_01505  purC; phosphoribosylaminoimidazole-succinocarboxamidesynthase [KO:K01923] [EC:6.3.2.6]
BN406_01500  purB; Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
BN406_03117  purH; bifunctionalphosphoribosylaminoimidazolecarboxam ide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
BN406_02211  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
BN406_02660  5'-nucleotidase precursor (signal peptide) protein [KO:K11751] [EC:3.1.3.5 3.6.1.45]
BN406_01264  surE; stationary phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
BN406_03263  deoD; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
BN406_02195  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
BN406_02511  hpt; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
BN406_00417  guaB; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
BN406_00899  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
BN406_00007  deoxyribonucleotide triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
BN406_01376  gpt; xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
BN406_06526  dehydrogenase [KO:K00087] [EC:1.17.1.4]
BN406_05867  xanthine dehydrogenase small subunit [KO:K13481] [EC:1.17.1.4]
BN406_05535  xanthine dehydrogenase small subunit [KO:K13481] [EC:1.17.1.4]
BN406_05866  XDH3; Xanthine dehydrogenase/oxidase [KO:K13482] [EC:1.17.1.4]
BN406_05534  XDH1; Xanthine dehydrogenase/oxidase [KO:K13482] [EC:1.17.1.4]
BN406_03527  yagR; Putative xanthine dehydrogenase YagR molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
BN406_06277  xanthine dehydrogenase [KO:K11177] [EC:1.17.1.4]
BN406_05669  xanthine dehydrogenase [KO:K11177] [EC:1.17.1.4]
BN406_05745  yagR; Putative xanthine dehydrogenase YagR molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
BN406_03528  yagS; Putative xanthine dehydrogenase YagS FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
BN406_06276  yagS5; Putative xanthine dehydrogenase YagS FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
BN406_05668  yagS1; Putative xanthine dehydrogenase YagS FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
BN406_05746  yagS3; Putative xanthine dehydrogenase YagS FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
BN406_03529  yagT; Putative xanthine dehydrogenase yagT iron-sulfur-binding subunit [KO:K13483]
BN406_06275  oxidoreductase [KO:K13483]
BN406_05667  aldehyde or xanthine dehydrogenase, iron-sulfur subunit protein [KO:K13483]
BN406_05747  yagT; Putative xanthine dehydrogenase yagT iron-sulfur-binding subunit [KO:K13483]
BN406_03445  guaA; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
BN406_02940  glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
BN406_05530  guaD1; Guanine deaminase [KO:K01487] [EC:3.5.4.3]
BN406_05860  guaD3; Guanine deaminase [KO:K01487] [EC:3.5.4.3]
BN406_00883  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
BN406_01288  nrd; ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
BN406_01253  deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
BN406_00839  hypothetical protein [KO:K06952] [EC:3.1.3.89]
BN406_00800  relA; GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase) protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
BN406_00922  hypothetical protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BN406_00412  Ppx/GppA phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BN406_03391  cya1; Adenylate cyclase 1 [KO:K01768] [EC:4.6.1.1]
BN406_03523  adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_00224  cyaE1; putative adenylate cyclase transmembrane protein [KO:K01768] [EC:4.6.1.1]
BN406_02627  cyaF2; adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_00924  cya2; Adenylate cyclase 2 [KO:K01768] [EC:4.6.1.1]
BN406_00119  cyaD1; adenylate cyclase transmembrane protein [KO:K01768] [EC:4.6.1.1]
BN406_01691  cyaD2; adenylate/guanylate cyclase transmembrane protein [KO:K01768] [EC:4.6.1.1]
BN406_02300  cyaC; adenylate cyclase transmembrane protein [KO:K01768] [EC:4.6.1.1]
BN406_06155  cya3; Putative adenylate cyclase 3 [KO:K01768] [EC:4.6.1.1]
BN406_05231  adenylate/guanylate cyclase with Chase sensor [KO:K01768] [EC:4.6.1.1]
BN406_02715  cyaG1; adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_05286  adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_05893  adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_04052  cyaN; guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_02851  cyaF1; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_06365  adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_06409  adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
BN406_04598  cya3; Putative adenylate cyclase 3 [KO:K01768] [EC:4.6.1.1]
BN406_02741  hypothetical protein [KO:K01768] [EC:4.6.1.1]
BN406_02585  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
BN406_03266  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
BN406_00701  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
BN406_02254  ade1; Adenine deaminase 1 [KO:K01486] [EC:3.5.4.2]
BN406_04676  ade3; Adenine deaminase 3 [KO:K01486] [EC:3.5.4.2]
BN406_04678  ade4; Adenine deaminase 4 [KO:K01486] [EC:3.5.4.2]
BN406_05874  ade2; Adenine deaminase 2 [KO:K01486] [EC:3.5.4.2]
BN406_01364  yfkN; Trifunctional nucleotide phosphoesterase protein YfkN [KO:K01119] [EC:3.1.4.16 3.1.3.6]
BN406_02614  hypothetical protein [KO:K09769] [EC:3.1.4.16]
BN406_01108  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
BN406_01198  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
BN406_00116  hypothetical protein [KO:K03651] [EC:3.1.4.53]
BN406_04788  metallophosphoesterase [KO:K03651] [EC:3.1.4.53]
BN406_04266  nodQ; Bifunctional enzyme NodQ [KO:K00955] [EC:2.7.7.4 2.7.1.25]
BN406_05924  nodQ; Bifunctional enzyme NodQ [KO:K00955] [EC:2.7.7.4 2.7.1.25]
BN406_00598  cysN; Sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
BN406_00599  cysD; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
BN406_04265  nodP; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
BN406_05925  nodP; Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
BN406_06385  hypothetical protein [KO:K22879] [EC:1.14.13.113]
BN406_05868  5-hydroxyisourate hydrolase 1 [KO:K07127] [EC:3.5.2.17]
BN406_05507  5-hydroxyisourate hydrolase 2 [KO:K07127] [EC:3.5.2.17]
BN406_05505  hypothetical protein [KO:K13485] [EC:4.1.1.97]
BN406_02452  hyuE; Hydantoin racemase [KO:K16841] [EC:5.1.99.3]
BN406_04633  hyuE; Hydantoin racemase [KO:K16841] [EC:5.1.99.3]
BN406_03933  allB; Allantoinase [KO:K01466] [EC:3.5.2.5]
BN406_03768  unnamed protein product [KO:K01466] [EC:3.5.2.5]
BN406_05504  cda1; Chitin deacetylase 1 [KO:K16842] [EC:3.5.2.5]
BN406_05869  urate catabolism protein [KO:K16842] [EC:3.5.2.5]
BN406_05870  allantoicase [KO:K01477] [EC:3.5.3.4]
BN406_05308  hypothetical protein [KO:K14977] [EC:3.5.3.26]
BN406_05506  allA1; Ureidoglycolate hydrolase 1 [KO:K01483] [EC:4.3.2.3]
BN406_05315  allA2; Ureidoglycolate hydrolase 2 [KO:K01483] [EC:4.3.2.3]
BN406_02319  ureC; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
BN406_02322  ureB; Urease subunit beta [KO:K01429] [EC:3.5.1.5]
BN406_02324  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
BN406_04165  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
smi00030  Pentose phosphate pathway
smi00220  Arginine biosynthesis
smi00250  Alanine, aspartate and glutamate metabolism
smi00260  Glycine, serine and threonine metabolism
smi00340  Histidine metabolism
smi00630  Glyoxylate and dicarboxylate metabolism
smi00730  Thiamine metabolism
smi00740  Riboflavin metabolism
smi00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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