KEGG   PATHWAY: sstn00270
Entry
sstn00270                   Pathway                                
Name
Cysteine and methionine metabolism - Solanum stenotomum
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
sstn00270  Cysteine and methionine metabolism
sstn00270

Module
sstn_M00021  Cysteine biosynthesis, serine => cysteine [PATH:sstn00270]
sstn_M00034  Methionine salvage pathway [PATH:sstn00270]
sstn_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:sstn00270]
Other DBs
GO: 0006534 0006555
Organism
Solanum stenotomum [GN:sstn]
Gene
125875981  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
125865945  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
125861967  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
125846800  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
125875890  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
125853356  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
125853376  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
125841148  cysteine synthase, chloroplastic/chromoplastic [KO:K01738] [EC:2.5.1.47]
125870555  cysteine synthase [KO:K01738] [EC:2.5.1.47]
125864458  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
125841735  bifunctional L-3-cyanoalanine synthase/cysteine synthase 2, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
125863736  cystathionine beta-lyase-like [KO:K01760] [EC:4.4.1.13]
125864715  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
125851856  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
125870520  homocysteine S-methyltransferase 2 isoform X1 [KO:K00547] [EC:2.1.1.10]
125866157  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
125870241  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like isoform X1 [KO:K00549] [EC:2.1.1.14]
125864810  S-adenosylmethionine synthase 3-like [KO:K00789] [EC:2.5.1.6]
125864860  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
125870186  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
125861228  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
125875308  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
125866959  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
125869952  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
125874427  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
125846520  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
125850870  spermidine synthase [KO:K00797] [EC:2.5.1.16]
125856317  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
125868803  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
125858198  spermine synthase [KO:K00797] [EC:2.5.1.16]
125874591  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
125874592  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
125874596  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
125851975  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
125852225  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01244] [EC:3.2.2.16]
125861437  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
125842236  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
125875485  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
125866000  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
125851872  acireductone dioxygenase 2 isoform X1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
125851874  acireductone dioxygenase 1-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
125851893  acireductone dioxygenase 2-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
125844900  uncharacterized protein LOC125844900 [KO:K23977] [EC:2.6.1.117]
125862455  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
125875915  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
125875916  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
125875917  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
125877185  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
125866014  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
125866237  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
125862376  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
125859074  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
125841281  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
125842154  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
125866575  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
125853463  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
125855285  DNA (cytosine-5)-methyltransferase 1B-like [KO:K00558] [EC:2.1.1.37]
125842260  DNA (cytosine-5)-methyltransferase CMT2-like [KO:K00558] [EC:2.1.1.37]
125844862  DNA (cytosine-5)-methyltransferase 1B-like [KO:K00558] [EC:2.1.1.37]
125868385  PWWP domain-containing protein 1-like [KO:K17398] [EC:2.1.1.37]
125852591  adenosylhomocysteinase isoform X1 [KO:K01251] [EC:3.13.2.1]
125862204  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
125862892  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
125852505  1-aminocyclopropane-1-carboxylate synthase 2 [KO:K20772] [EC:4.4.1.14]
125842385  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
125842388  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
125842393  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
125848507  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
125848582  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
125876731  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
125867071  1-aminocyclopropane-1-carboxylate synthase 4 [KO:K01762] [EC:4.4.1.14]
125867074  1-aminocyclopropane-1-carboxylate synthase 4-like [KO:K01762] [EC:4.4.1.14]
125868397  1-aminocyclopropane-1-carboxylate synthase 4-like [KO:K01762] [EC:4.4.1.14]
125868399  1-aminocyclopropane-1-carboxylate synthase 4-like [KO:K01762] [EC:4.4.1.14]
125855503  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
125859844  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
125846358  1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
125849272  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
125877115  1-aminocyclopropane-1-carboxylate oxidase 4 [KO:K05933] [EC:1.14.17.4]
125877116  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
125877168  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
125872105  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
125844719  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
125846428  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
125862134  1-aminocyclopropane-1-carboxylate oxidase 2 [KO:K05933] [EC:1.14.17.4]
125867284  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
125844766  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
125874542  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
125868195  uncharacterized protein LOC125868195 [KO:K00133] [EC:1.2.1.11]
125860583  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
125847060  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
125863148  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
125863149  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
125875695  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
125855530  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
125855531  branched-chain-amino-acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
125859846  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
125846366  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
125865502  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
125854359  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
125843306  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
125873692  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
125876421  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
125842015  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
125875724  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
125865411  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
125878283  aspartate aminotransferase, chloroplastic isoform X1 [KO:K00811] [EC:2.6.1.1]
125848097  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
125876567  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
125841474  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
125842639  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
125863390  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
125860936  putative D-cysteine desulfhydrase 1, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
125854924  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
125873337  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
125871537  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
125845142  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
125876908  malate dehydrogenase 1, mitochondrial [KO:K00026] [EC:1.1.1.37]
125852011  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
125853573  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
125869035  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
125870677  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
125857623  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
125864854  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125857793  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125858496  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125846794  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
sstn00010  Glycolysis / Gluconeogenesis
sstn00250  Alanine, aspartate and glutamate metabolism
sstn00260  Glycine, serine and threonine metabolism
sstn00290  Valine, leucine and isoleucine biosynthesis
sstn00430  Taurine and hypotaurine metabolism
sstn00480  Glutathione metabolism
sstn00620  Pyruvate metabolism
sstn00640  Propanoate metabolism
sstn00770  Pantothenate and CoA biosynthesis
sstn00900  Terpenoid backbone biosynthesis
sstn00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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