KEGG   PATHWAY: sstn04146
Entry
sstn04146                   Pathway                                
Name
Peroxisome - Solanum stenotomum
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
sstn04146  Peroxisome
sstn04146

Other DBs
GO: 0005777
Organism
Solanum stenotomum [GN:sstn]
Gene
125851682  peroxisome biogenesis protein 16 isoform X1 [KO:K13335]
125873209  peroxisome biogenesis protein 16-like isoform X1 [KO:K13335]
125863144  peroxisome biogenesis protein 3-2-like [KO:K13336]
125858106  peroxisome biogenesis protein 3-2 [KO:K13336]
125841772  peroxisome biogenesis protein 19-1-like [KO:K13337]
125872694  peroxisome biogenesis protein 19-2-like [KO:K13337]
125855646  peroxisome biogenesis protein 1 isoform X1 [KO:K13338]
125872556  peroxisome biogenesis protein 6 [KO:K13339]
125858611  peroxisome biogenesis protein 7-like [KO:K13341]
125846443  peroxisome biogenesis protein 7-like [KO:K13341]
125866214  peroxisome biogenesis protein 5 isoform X1 [KO:K13342]
125872235  peroxisomal membrane protein PEX14-like isoform X1 [KO:K13343]
125860438  LOW QUALITY PROTEIN: peroxisomal membrane protein PEX14 [KO:K13343]
125852559  peroxisomal membrane protein 13-like [KO:K13344]
125869064  peroxisome biogenesis protein 12 [KO:K13345]
125855055  peroxisome biogenesis factor 10 [KO:K13346]
125874022  peroxisome biogenesis protein 2 [KO:K06664]
125849134  peroxisomal membrane protein PMP22-like [KO:K13347]
125860528  peroxisomal membrane protein PMP22-like [KO:K13347]
125873236  peroxisomal membrane protein PMP22 [KO:K13347]
125860799  protein sym-1 [KO:K13347]
125875626  uncharacterized protein LOC125875626 [KO:K13348]
125875734  uncharacterized protein LOC125875734 [KO:K13348]
125863358  protein SYM1-like [KO:K13348]
125864388  protein SYM1-like [KO:K13348]
125864534  protein SYM1-like [KO:K13348]
125843622  protein SYM1-like isoform X1 [KO:K13348]
125843997  uncharacterized protein LOC125843997 [KO:K13348]
125845259  uncharacterized protein LOC125845259 [KO:K13348]
125866803  peroxisomal nicotinamide adenine dinucleotide carrier isoform X1 [KO:K13354]
125854814  peroxisomal nicotinamide adenine dinucleotide carrier-like [KO:K13354]
125846875  2-hydroxyacyl-CoA lyase [KO:K12261] [EC:4.1.2.63]
125868342  phytanoyl-CoA dioxygenase [KO:K00477] [EC:1.14.11.18]
125864400  acyl-coenzyme A oxidase 4, peroxisomal-like isoform X1 [KO:K00232] [EC:1.3.3.6]
125864743  acyl-coenzyme A oxidase 4, peroxisomal-like isoform X1 [KO:K00232] [EC:1.3.3.6]
125866229  acyl-coenzyme A oxidase 3, peroxisomal-like isoform X1 [KO:K00232] [EC:1.3.3.6]
125855214  acyl-coenzyme A oxidase 2, peroxisomal [KO:K00232] [EC:1.3.3.6]
125841509  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
125843170  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
125870903  3-ketoacyl-CoA thiolase 2, peroxisomal [KO:K07513] [EC:2.3.1.16]
125870928  3-ketoacyl CoA thiolase 1, peroxisomal [KO:K07513] [EC:2.3.1.16]
125875879  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] [KO:K13237] [EC:1.3.1.124]
125869083  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, peroxisomal isoform X1 [KO:K12663] [EC:5.3.3.21]
125854226  ABC transporter D family member 1 [KO:K25819] [EC:7.6.2.4]
125875803  long chain acyl-CoA synthetase 8-like [KO:K01897] [EC:6.2.1.3]
125863244  long chain acyl-CoA synthetase 8-like [KO:K01897] [EC:6.2.1.3]
125876949  long chain acyl-CoA synthetase 6, peroxisomal-like [KO:K01897] [EC:6.2.1.3]
125850378  long chain acyl-CoA synthetase 4-like [KO:K01897] [EC:6.2.1.3]
125851188  probable acyl-activating enzyme 16, chloroplastic [KO:K01897] [EC:6.2.1.3]
125841901  long chain acyl-CoA synthetase 4-like [KO:K01897] [EC:6.2.1.3]
125870941  long chain acyl-CoA synthetase 6, peroxisomal-like [KO:K01897] [EC:6.2.1.3]
125870943  long chain acyl-CoA synthetase 6, peroxisomal-like [KO:K01897] [EC:6.2.1.3]
125842607  long chain acyl-CoA synthetase 4-like [KO:K01897] [EC:6.2.1.3]
125871865  probable CoA ligase CCL6 [KO:K01897] [EC:6.2.1.3]
125843607  long chain acyl-CoA synthetase 9, chloroplastic [KO:K01897] [EC:6.2.1.3]
125847111  long chain acyl-CoA synthetase 1-like [KO:K01897] [EC:6.2.1.3]
125873167  nudix hydrolase 19, chloroplastic [KO:K03426] [EC:3.6.1.22]
125849104  uncharacterized protein LOC125849104 isoform X1 [KO:K01578] [EC:4.1.1.9]
125851126  fatty acyl-CoA reductase 3-like [KO:K13356] [EC:1.2.1.84]
125853548  fatty acyl-CoA reductase 3-like [KO:K13356] [EC:1.2.1.84]
125870977  fatty acyl-CoA reductase 2, chloroplastic-like [KO:K13356] [EC:1.2.1.84]
125871188  fatty acyl-CoA reductase 2, chloroplastic-like isoform X1 [KO:K13356] [EC:1.2.1.84]
125871886  fatty acyl-CoA reductase 2, chloroplastic-like [KO:K13356] [EC:1.2.1.84]
125871887  fatty acyl-CoA reductase 2, chloroplastic-like [KO:K13356] [EC:1.2.1.84]
125859503  fatty acyl-CoA reductase 2, chloroplastic [KO:K13356] [EC:1.2.1.84]
125872422  fatty acyl-CoA reductase 3-like [KO:K13356] [EC:1.2.1.84]
125872807  fatty acyl-CoA reductase 3 [KO:K13356] [EC:1.2.1.84]
125844095  alcohol-forming fatty acyl-CoA reductase-like [KO:K13356] [EC:1.2.1.84]
125844097  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
125844099  fatty acyl-CoA reductase 3-like [KO:K13356] [EC:1.2.1.84]
125844100  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
125844137  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
125844579  alcohol-forming fatty acyl-CoA reductase-like [KO:K13356] [EC:1.2.1.84]
125860011  fatty acyl-CoA reductase 3-like [KO:K13356] [EC:1.2.1.84]
125873204  probable fatty acyl-CoA reductase 4 [KO:K13356] [EC:1.2.1.84]
125873206  fatty acyl-CoA reductase 3-like [KO:K13356] [EC:1.2.1.84]
125841789  mevalonate kinase [KO:K00869] [EC:2.7.1.36]
125870792  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
125847554  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
125871596  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
125844764  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
125841534  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
125869835  uncharacterized protein LOC125869835 [KO:K01640] [EC:4.1.3.4]
125844394  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
125875555  glycolate oxidase 1 [KO:K11517] [EC:1.1.3.15]
125865802  glycolate oxidase 1-like [KO:K11517] [EC:1.1.3.15]
125857672  peroxisomal (S)-2-hydroxyacid oxidase GLO3-like [KO:K11517] [EC:1.1.3.15]
125842473  glycolate oxidase 1-like [KO:K11517] [EC:1.1.3.15]
125858158  peroxisomal (S)-2-hydroxyacid oxidase GLO4-like [KO:K11517] [EC:1.1.3.15]
125858160  peroxisomal (S)-2-hydroxyacid oxidase GLO4-like [KO:K11517] [EC:1.1.3.15]
125858161  peroxisomal (S)-2-hydroxyacid oxidase GLO4-like [KO:K11517] [EC:1.1.3.15]
125863053  catalase isozyme 2 [KO:K03781] [EC:1.11.1.6]
125854435  catalase isozyme 3 [KO:K03781] [EC:1.11.1.6]
125846792  catalase isozyme 2 [KO:K03781] [EC:1.11.1.6]
125842150  superoxide dismutase [Cu-Zn] 2 [KO:K04565] [EC:1.15.1.1]
125844706  superoxide dismutase [Cu-Zn], chloroplastic [KO:K04565] [EC:1.15.1.1]
125872110  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
125859326  superoxide dismutase [Fe], chloroplastic [KO:K04564] [EC:1.15.1.1]
125872617  superoxide dismutase [Fe], chloroplastic isoform X1 [KO:K04564] [EC:1.15.1.1]
125872618  superoxide dismutase [Fe], chloroplastic-like [KO:K04564] [EC:1.15.1.1]
125846728  superoxide dismutase [Fe] 3, chloroplastic isoform X1 [KO:K04564] [EC:1.15.1.1]
125845232  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125844155  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
125861826  tropinone reductase-like 3 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
sstn00071  Fatty acid degradation
sstn00230  Purine metabolism
sstn00564  Glycerophospholipid metabolism
sstn00565  Ether lipid metabolism
sstn00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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