KEGG   PATHWAY: tng04146
Entry
tng04146                    Pathway                                
Name
Peroxisome - Tetraodon nigroviridis (spotted green pufferfish)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
tng04146  Peroxisome
tng04146

Other DBs
GO: 0005777
Organism
Tetraodon nigroviridis (spotted green pufferfish) [GN:tng]
Gene
GSTEN00000354G001  unnamed protein product [KO:K13335]
GSTEN00008346G001  unnamed protein product [KO:K13335]
GSTEN00006257G001  unnamed protein product [KO:K13336]
GSTEN00009448G001  unnamed protein product [KO:K05677] [EC:7.6.2.4]
GSTEN00031516G001  unnamed protein product [KO:K13338]
GSTEN00008938G001  unnamed protein product [KO:K13339]
GSTEN00023826G001  unnamed protein product [KO:K13340]
GSTEN00003978G001  unnamed protein product [KO:K13341]
GSTEN00015315G001  unnamed protein product [KO:K13342]
GSTEN00015317G001  unnamed protein product [KO:K13342]
GSTEN00028926G001  unnamed protein product [KO:K13342]
GSTEN00028256G001  unnamed protein product [KO:K13343]
GSTEN00031764G001  unnamed protein product [KO:K13344]
GSTEN00026152G001  unnamed protein product [KO:K13345]
GSTEN00005286G001  unnamed protein product [KO:K13346]
GSTEN00015451G001  unnamed protein product [KO:K06664]
GSTEN00029514G001  unnamed protein product [KO:K13347]
GSTEN00019310G001  unnamed protein product [KO:K13348]
GSTEN00019311G001  unnamed protein product [KO:K13348]
GSTEN00009787G001  unnamed protein product [KO:K13348]
GSTEN00011847G001  unnamed protein product [KO:K13349]
GSTEN00021275G001  unnamed protein product [KO:K13349]
GSTEN00033837G001  unnamed protein product [KO:K13350]
GSTEN00035627G001  unnamed protein product [KO:K13351]
GSTEN00008798G001  unnamed protein product [KO:K13352]
GSTEN00008795G001  unnamed protein product [KO:K13352]
GSTEN00011529G001  unnamed protein product [KO:K13353]
GSTEN00003711G001  unnamed protein product [KO:K13354]
GSTEN00033386G001  unnamed protein product [KO:K13354]
GSTEN00034133G001  unnamed protein product [KO:K12261] [EC:4.1.2.63]
GSTEN00014447G001  unnamed protein product [KO:K01796] [EC:5.1.99.4]
GSTEN00013261G001  unnamed protein product [KO:K00477] [EC:1.14.11.18]
GSTEN00006680G001  unnamed protein product [KO:K00232] [EC:1.3.3.6]
GSTEN00032511G001  unnamed protein product [KO:K00232] [EC:1.3.3.6]
GSTEN00030945G001  unnamed protein product [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
GSTEN00013363G001  unnamed protein product [KO:K08764] [EC:2.3.1.176]
GSTEN00014025G001  unnamed protein product [KO:K00659] [EC:2.3.1.65 3.1.2.2]
GSTEN00019694G001  unnamed protein product [KO:K00659] [EC:2.3.1.65 3.1.2.2]
GSTEN00030532G001  unnamed protein product [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
GSTEN00024053G001  unnamed protein product [KO:K13237] [EC:1.3.1.124]
GSTEN00026821G001  unnamed protein product [KO:K12663] [EC:5.3.3.21]
GSTEN00011707G001  unnamed protein product [KO:K05675] [EC:7.6.2.4]
GSTEN00019846G001  unnamed protein product [KO:K05676] [EC:7.6.2.4]
GSTEN00030339G001  unnamed protein product [KO:K05678] [EC:7.6.2.8]
GSTEN00018048G001  unnamed protein product [KO:K08746] [EC:6.2.1.- 6.2.1.3]
GSTEN00018016G001  unnamed protein product [KO:K08746] [EC:6.2.1.- 6.2.1.3]
GSTEN00025600G001  unnamed protein product [KO:K08746] [EC:6.2.1.- 6.2.1.3]
GSTEN00025601G001  unnamed protein product [KO:K08746] [EC:6.2.1.- 6.2.1.3]
GSTEN00001203G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00033506G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00028441G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00026940G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00019176G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00020444G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00029871G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00026734G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00029359G001  unnamed protein product [KO:K01897] [EC:6.2.1.3]
GSTEN00015098G001  unnamed protein product [KO:K07753] [EC:1.3.1.38]
GSTEN00025321G001  unnamed protein product [KO:K13239] [EC:5.3.3.8]
GSTEN00031031G001  unnamed protein product [KO:K03426] [EC:3.6.1.22]
GSTEN00034343G001  unnamed protein product [KO:K03426] [EC:3.6.1.22]
GSTEN00008120G001  unnamed protein product [KO:K13355] [EC:3.6.1.77]
GSTEN00014144G001  unnamed protein product [KO:K11992] [EC:3.1.2.27]
GSTEN00013846G001  unnamed protein product [KO:K00624] [EC:2.3.1.7]
GSTEN00025090G001  unnamed protein product [KO:K00624] [EC:2.3.1.7]
GSTEN00034002G001  unnamed protein product [KO:K05940] [EC:2.3.1.137]
GSTEN00016754G001  unnamed protein product [KO:K01578] [EC:4.1.1.9]
GSTEN00035474G001  unnamed protein product [KO:K00649] [EC:2.3.1.42]
GSTEN00030246G001  unnamed protein product [KO:K00649] [EC:2.3.1.42]
GSTEN00031469G001  unnamed protein product [KO:K00803] [EC:2.5.1.26]
GSTEN00021530G001  unnamed protein product [KO:K13356] [EC:1.2.1.84]
GSTEN00029531G001  unnamed protein product [KO:K00869] [EC:2.7.1.36]
GSTEN00011540G001  unnamed protein product [KO:K13273] [EC:2.7.4.2]
GSTEN00028401G001  unnamed protein product [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
GSTEN00004883G001  unnamed protein product [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
GSTEN00029509G001  unnamed protein product [KO:K00273] [EC:1.4.3.3]
GSTEN00035753G001  unnamed protein product [KO:K00272] [EC:1.4.3.1]
GSTEN00021781G001  unnamed protein product [KO:K00031] [EC:1.1.1.42]
GSTEN00035635G001  unnamed protein product [KO:K00031] [EC:1.1.1.42]
GSTEN00021458G001  unnamed protein product [KO:K00031] [EC:1.1.1.42]
GSTEN00008761G001  unnamed protein product [KO:K00306] [EC:1.5.3.1 1.5.3.7]
GSTEN00030684G001  unnamed protein product [KO:K01640] [EC:4.1.3.4]
GSTEN00031359G001  unnamed protein product [KO:K01640] [EC:4.1.3.4]
GSTEN00029148G001  unnamed protein product [KO:K11517] [EC:1.1.3.15]
GSTEN00026505G001  unnamed protein product [KO:K11517] [EC:1.1.3.15]
GSTEN00010366G001  unnamed protein product [KO:K03781] [EC:1.11.1.6]
GSTEN00018898G001  unnamed protein product [KO:K04565] [EC:1.15.1.1]
GSTEN00023108G001  unnamed protein product [KO:K04564] [EC:1.15.1.1]
GSTEN00013358G001  unnamed protein product [KO:K13279] [EC:1.11.1.24]
GSTEN00022646G001  unnamed protein product [KO:K13279] [EC:1.11.1.24]
GSTEN00019421G001  unnamed protein product [KO:K08726] [EC:3.3.2.10 3.1.3.76]
GSTEN00012569G001  unnamed protein product [KO:K00106] [EC:1.17.1.4 1.17.3.2]
GSTEN00025883G001  unnamed protein product [KO:K11147] [EC:1.1.-.-]
GSTEN00025891G001  unnamed protein product [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
tng00071  Fatty acid degradation
tng00120  Primary bile acid biosynthesis
tng00230  Purine metabolism
tng00564  Glycerophospholipid metabolism
tng00565  Ether lipid metabolism
tng00830  Retinol metabolism
tng00900  Terpenoid backbone biosynthesis
tng03320  PPAR signaling pathway
KO pathway
ko04146   
LinkDB

DBGET integrated database retrieval system