KEGG   PATHWAY: tnl04141
Entry
tnl04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Trichoplusia ni (cabbage looper)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tnl04141  Protein processing in endoplasmic reticulum
tnl04141

Other DBs
GO: 0030433 0034976
Organism
Trichoplusia ni (cabbage looper) [GN:tnl]
Gene
113502385  protein transport protein Sec61 subunit alpha [KO:K10956]
113500970  protein transport protein Sec61 subunit beta-like [KO:K09481]
113501463  protein transport protein Sec61 subunit beta-like [KO:K09481]
113506724  protein transport protein Sec61 subunit gamma [KO:K07342]
113508202  protein transport protein Sec61 subunit gamma [KO:K07342]
113498541  translocation protein SEC62 [KO:K12275]
113495460  translocation protein SEC63 homolog [KO:K09540]
113496782  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
113496346  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
113505277  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
113504454  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
113504736  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like isoform X1 [KO:K07151] [EC:2.4.99.18]
113492948  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
113504768  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like isoform X1 [KO:K07151] [EC:2.4.99.18]
113506805  tumor suppressor candidate 3 [KO:K19478]
113501155  oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
113493416  transmembrane protein 258 [KO:K26502]
113492303  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
113504836  ribosome-binding protein 1-like isoform X1 [KO:K14000]
113495919  hypoxia up-regulated protein 1-like [KO:K09486]
113508064  hypoxia up-regulated protein 1 [KO:K09486]
113494618  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
113493285  dnaJ homolog shv [KO:K09517]
113508788  uncharacterized protein F54F2.9 [KO:K09521]
113493013  dnaJ homolog subfamily C member 3 [KO:K09523]
113497229  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
113506484  endoplasmin [KO:K09487]
113506768  LOW QUALITY PROTEIN: neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
113505102  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
113496754  glucosidase 2 subunit beta [KO:K08288]
113508548  calnexin [KO:K08054]
113501793  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
113502294  calreticulin [KO:K08057]
113500731  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
113493937  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
113494813  vesicular integral-membrane protein VIP36-like [KO:K10082]
113506244  vesicular integral-membrane protein VIP36-like [KO:K10082]
113500159  protein ERGIC-53 [KO:K10080]
113501550  prolactin regulatory element-binding protein [KO:K14003]
113500780  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
113505023  protein SEC13 homolog [KO:K14004]
113497802  protein transport protein Sec31A isoform X1 [KO:K14005]
113504818  protein transport protein Sec23A isoform X1 [KO:K14006]
113498362  protein transport protein Sec24C isoform X1 [KO:K14007]
113495237  protein transport protein Sec24A-like [KO:K14007]
113507418  LOW QUALITY PROTEIN: protein transport protein Sec24A-like [KO:K14007]
113492729  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
113508487  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
113495555  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
113501048  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
113496778  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
113493769  protein windbeutel [KO:K09586]
113496860  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
113504600  ero1-like protein isoform X1 [KO:K10950] [EC:1.8.4.-]
113506670  ero1-like protein [KO:K10950] [EC:1.8.4.-]
113497153  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
113498050  translocon-associated protein subunit alpha-like [KO:K13249]
113507392  translocon-associated protein subunit alpha-like [KO:K13249]
113502129  translocon-associated protein subunit beta [KO:K13250]
113498752  translocon-associated protein subunit gamma [KO:K13251]
113492305  translocon-associated protein subunit delta [KO:K04571]
113502117  B-cell receptor-associated protein 31 [KO:K14009]
113503602  B-cell receptor-associated protein 31-like [KO:K14009]
113496311  translocating chain-associated membrane protein 1 [KO:K14010]
113494174  derlin-1 [KO:K11519]
113498431  derlin-2 [KO:K13989]
113504322  UBX domain-containing protein 4 [KO:K24348]
113497282  UBX domain-containing protein 1 [KO:K24348]
113499144  UBX domain-containing protein 6 isoform X1 [KO:K14011]
113495987  NSFL1 cofactor p47 [KO:K14012]
113502223  small VCP/p97-interacting protein isoform X1 [KO:K14014]
113505390  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
113494870  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
113493815  ubiquitin fusion degradation protein 1 homolog isoform X1 [KO:K14016]
113502297  heat shock protein 70 A1-like [KO:K03283]
113508974  heat shock protein 68-like [KO:K03283]
113495560  heat shock protein 68-like [KO:K03283]
113496692  heat shock protein 68-like [KO:K03283]
113502431  heat shock protein 70 A1-like [KO:K03283]
113507166  heat shock protein 68-like [KO:K03283]
113506423  heat shock 70 kDa protein cognate 4 [KO:K03283]
113496267  heat shock protein 68-like [KO:K03283]
113503195  major heat shock 70 kDa protein Ab-like [KO:K03283]
113500490  dnaJ homolog subfamily A member 1 [KO:K09502]
113501015  dnaJ homolog subfamily A member 2-like [KO:K09503]
113501513  dnaJ protein homolog 1 [KO:K09507]
113507074  dnaJ homolog subfamily B member 12 isoform X1 [KO:K09518]
113492644  dnaJ homolog subfamily C member 5 [KO:K09525]
113496266  heat shock protein 83 [KO:K04079]
113508321  97 kDa heat shock protein isoform X1 [KO:K09485]
113503329  BAG family molecular chaperone regulator 2 [KO:K09556]
113495605  hsp70-binding protein 1 [KO:K09562]
113501922  alpha-crystallin A chain-like [KO:K09541]
113497994  protein lethal(2)essential for life-like [KO:K09542]
113498137  protein lethal(2)essential for life-like [KO:K09542]
113498138  protein lethal(2)essential for life-like [KO:K09542]
113498141  protein lethal(2)essential for life-like [KO:K09542]
113504786  protein lethal(2)essential for life-like [KO:K09542]
113494655  protein lethal(2)essential for life-like [KO:K09542]
113498233  protein lethal(2)essential for life-like [KO:K09542]
113498102  protein lethal(2)essential for life-like [KO:K09542]
113498115  protein lethal(2)essential for life-like [KO:K09542]
113498116  protein lethal(2)essential for life-like [KO:K09542]
113502014  protein lethal(2)essential for life-like [KO:K09542]
113496127  protein lethal(2)essential for life-like [KO:K09542]
113500950  protein lethal(2)essential for life-like [KO:K09542]
113501995  protein lethal(2)essential for life-like [KO:K09542]
113500546  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
113502317  phospholipase A-2-activating protein [KO:K14018]
113508021  UV excision repair protein RAD23 homolog A [KO:K10839]
113503585  ubiquilin-1 isoform X1 [KO:K04523]
113502704  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
113507644  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
113508182  eukaryotic translation initiation factor 2-alpha kinase-like [KO:K08860] [EC:2.7.11.1]
113494236  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113496582  activating transcription factor of chaperone [KO:K04374]
113494489  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
113494834  wolframin isoform X1 [KO:K14020]
113494015  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
113505775  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
113506682  X-box-binding protein 1 [KO:K09027]
113507874  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
113492025  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
113497144  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
113494585  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
113503670  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
113497310  E3 ubiquitin-protein ligase MARCH6 isoform X1 [KO:K10661] [EC:2.3.2.27]
113505030  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
113503304  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
113502801  ubiquitin-conjugating enzyme E2 G1-like isoform X1 [KO:K10575] [EC:2.3.2.23]
113506541  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
113495798  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
113504865  E3 ubiquitin-protein ligase synoviolin B isoform X1 [KO:K10601] [EC:2.3.2.27]
113504593  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
113505434  uncharacterized protein LOC113505434 isoform X1 [KO:K14025]
113504919  protein sel-1 homolog 1 isoform X1 [KO:K14026]
113505278  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
113494695  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
113497745  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
113508302  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
113504289  cullin-1 [KO:K03347]
113508299  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
tnl00510  N-Glycan biosynthesis
tnl03050  Proteasome
tnl03060  Protein export
KO pathway
ko04141   
LinkDB

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