KEGG   PATHWAY: tpre04141
Entry
tpre04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Trichogramma pretiosum
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tpre04141  Protein processing in endoplasmic reticulum
tpre04141

Other DBs
GO: 0030433 0034976
Organism
Trichogramma pretiosum [GN:tpre]
Gene
106659270  protein transport protein Sec61 subunit alpha [KO:K10956]
106657065  protein transport protein Sec61 subunit alpha-like [KO:K10956]
106657468  protein transport protein Sec61 subunit beta [KO:K09481]
106651761  protein transport protein Sec61 subunit gamma-like [KO:K07342]
106654173  protein transport protein Sec61 subunit gamma [KO:K07342]
106649791  translocation protein SEC62 [KO:K12275]
106656420  translocation protein SEC63 homolog [KO:K09540]
106652507  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
106658169  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
106651502  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
106658725  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
106648161  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
106657502  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
106650372  tumor suppressor candidate 3 [KO:K19478]
106655477  oligosaccharyltransferase complex subunit ostc-B [KO:K26501]
106659064  transmembrane protein 258 [KO:K26502]
106659062  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
106651861  nucleotide exchange factor SIL1 [KO:K14001]
106648795  hypoxia up-regulated protein 1 [KO:K09486]
106655554  heat shock 70 kDa protein cognate 3 isoform X1 [KO:K09490] [EC:3.6.4.10]
106650124  dnaJ homolog shv [KO:K09517]
106659126  dnaJ homolog subfamily C member 1 [KO:K09521]
106654773  dnaJ homolog subfamily C member 3 [KO:K09523]
106660444  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
106652850  endoplasmin [KO:K09487]
106657952  neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
106658052  glucosidase 2 subunit beta isoform X1 [KO:K08288]
106651553  calnexin-like [KO:K08054]
106653199  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
106657669  calreticulin [KO:K08057]
106654476  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
106656965  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
106655187  vesicular integral-membrane protein VIP36 [KO:K10082]
106657520  prolactin regulatory element-binding protein [KO:K14003]
106651629  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
106650813  protein SEC13 homolog [KO:K14004]
106648070  protein transport protein Sec23A [KO:K14006]
106652949  protein transport protein Sec24A isoform X1 [KO:K14007]
106651175  protein transport protein Sec24C-like [KO:K14007]
106650931  protein transport protein Sec24C-like [KO:K14007]
106658163  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
106650854  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
106654909  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
106651755  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
106651396  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
106650809  ero1-like protein [KO:K10950] [EC:1.8.4.-]
106654340  endoplasmic reticulum lectin 1 [KO:K14008]
106660178  translocon-associated protein subunit alpha [KO:K13249]
106654790  translocon-associated protein subunit beta [KO:K13250]
106660043  translocon-associated protein subunit gamma [KO:K13251]
106658760  translocon-associated protein subunit delta [KO:K04571]
106655229  B-cell receptor-associated protein 31 [KO:K14009]
106655827  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
106660228  derlin-1 [KO:K11519]
106651057  derlin-2 isoform X1 [KO:K13989]
106659019  UBX domain-containing protein 4 isoform X1 [KO:K24348]
106656988  UBX domain-containing protein 1 [KO:K24348]
106650029  UBX domain-containing protein 6 [KO:K14011]
106657467  NSFL1 cofactor p47-like [KO:K14012]
106657614  NSFL1 cofactor p47 [KO:K14012]
106658609  uncharacterized protein LOC106658609 [KO:K14014]
106657973  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
106648379  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
106656635  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
106648008  heat shock 70 kDa protein cognate 4 [KO:K03283]
106659289  heat shock 70 kDa protein cognate 4-like [KO:K03283]
106656683  heat shock protein 68-like [KO:K03283]
106648077  dnaJ protein homolog 1-like [KO:K09507]
106650461  dnaJ homolog subfamily B member 12 [KO:K09518]
106658431  dnaJ homolog subfamily C member 5-like isoform X3 [KO:K09525]
106650483  heat shock protein 83 [KO:K04079]
106658021  97 kDa heat shock protein [KO:K09485]
106653082  BAG family molecular chaperone regulator 2 [KO:K09556]
106657571  hsp70-binding protein 1 isoform X1 [KO:K09562]
106652033  protein lethal(2)essential for life-like [KO:K09542]
106652693  protein lethal(2)essential for life-like [KO:K09542]
106652696  protein lethal(2)essential for life-like [KO:K09542]
106652697  alpha-crystallin A chain-like [KO:K09542]
106652702  protein lethal(2)essential for life-like [KO:K09542]
106653013  protein lethal(2)essential for life-like [KO:K09542]
106656627  protein lethal(2)essential for life-like [KO:K09542]
106652039  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
106653738  phospholipase A-2-activating protein-like [KO:K14018]
106653739  phospholipase A-2-activating protein-like [KO:K14018]
106659035  UV excision repair protein RAD23 homolog B [KO:K10839]
106660058  ubiquilin-1 [KO:K04523]
106656103  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
106653530  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
106654182  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
106656184  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106659039  myb-like protein Q isoform X1 [KO:K04374]
106655604  uncharacterized protein LOC106655604 isoform X1 [KO:K09049]
106655184  wolframin isoform X1 [KO:K14020]
106660560  membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
106658951  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
106648386  uncharacterized protein LOC106648386 [KO:K09027]
106648212  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106651350  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:2.7.11.25]
106650145  dual specificity mitogen-activated protein kinase kinase hemipterous-like [KO:K04431] [EC:2.7.12.2]
106656715  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
106659865  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
106651767  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
106658051  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
106658929  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
106652198  E3 ubiquitin-protein ligase synoviolin B-like isoform X1 [KO:K10601] [EC:2.3.2.27]
106659813  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
106657858  uncharacterized protein LOC106657858 [KO:K14025]
106648663  protein sel-1 homolog 1 [KO:K14026]
106650401  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
106651215  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
106658818  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
106652040  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
106658241  cullin-1 [KO:K03347]
111693248  E3 ubiquitin ligase complex SCF subunit sconC-like [KO:K03094]
111693284  S-phase kinase-associated protein 1-like [KO:K03094]
111693285  S-phase kinase-associated protein 1-like [KO:K03094]
111693220  E3 ubiquitin ligase complex SCF subunit sconC-like [KO:K03094]
106655567  S-phase kinase-associated protein 1-like [KO:K03094]
106655568  S-phase kinase-associated protein 1-like [KO:K03094]
106651886  S-phase kinase-associated protein 1-like [KO:K03094]
106654121  S-phase kinase-associated protein 1-like [KO:K03094]
106654235  S-phase kinase-associated protein 1-like [KO:K03094]
106654752  S-phase kinase-associated protein 1-like [KO:K03094]
106655286  S-phase kinase-associated protein 1-like [KO:K03094]
106655287  S-phase kinase-associated protein 1-like [KO:K03094]
106655288  S-phase kinase-associated protein 1-like isoform X1 [KO:K03094]
106655565  S-phase kinase-associated protein 1-like [KO:K03094]
106655985  E3 ubiquitin ligase complex SCF subunit sconC-like [KO:K03094]
106656073  S-phase kinase-associated protein 1-like [KO:K03094]
106656153  S-phase kinase-associated protein 1-like [KO:K03094]
106656340  S-phase kinase-associated protein 1-like [KO:K03094]
106657892  S-phase kinase-associated protein 1-like [KO:K03094]
111694590  S-phase kinase-associated protein 1-like [KO:K03094]
106655795  F-box only protein 6-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
tpre00510  N-Glycan biosynthesis
tpre03050  Proteasome
tpre03060  Protein export
KO pathway
ko04141   
LinkDB

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