KEGG   PATHWAY: tup00260
Entry
tup00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Tupaia chinensis (Chinese tree shrew)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
tup00260  Glycine, serine and threonine metabolism
tup00260

Module
tup_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:tup00260]
tup_M00047  Creatine pathway [PATH:tup00260]
tup_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:tup00260]
tup_M00555  Betaine biosynthesis, choline => betaine [PATH:tup00260]
tup_M00621  Glycine cleavage system [PATH:tup00260]
tup_M00974  Betaine metabolism, animals, betaine => glycine [PATH:tup00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102473644  SHMT1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
102469908  SHMT2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
102487945  AGXT; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
102477381  GRHPR; glyoxylate and hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102499777  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
102481127  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
102483707  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
102487406  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
102496494  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102470145  PHGDH; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102501617  PSAT1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]
102477687  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
102502803  GCAT; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
102502177  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
102479249  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
102494737  ALAS2; 5'-aminolevulinate synthase 2 [KO:K00643] [EC:2.3.1.37]
102501420  ALAS1; 5'-aminolevulinate synthase 1 [KO:K00643] [EC:2.3.1.37]
102479142  MAOB; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
102479553  MAOA; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
102490650  AOC2; amine oxidase, copper containing 2 [KO:K00276] [EC:1.4.3.21]
102491763  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
102491341  AOC3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]
102489022  GLDC; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
102486635  AMT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
102470087  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
102494178  glycine cleavage system H protein, mitochondrial [KO:K02437]
102501318  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
102487286  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
106735306  GCSH; glycine cleavage system protein H [KO:K02437]
102502344  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
106733475  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
102485290  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
102503254  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
102484475  DAO; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
102501713  AGXT2; alanine--glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102470318  GATM; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
102486225  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
102482117  CHDH; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
102495542  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
102489167  BHMT; betaine--homocysteine S-methyltransferase [KO:K00544] [EC:2.1.1.5]
102489576  DMGDH; dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
102500564  PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
102468288  SARDH; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]
102501380  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
102470867  CBS; cystathionine-beta-synthase [KO:K01697] [EC:4.2.1.22]
102493127  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
102488112  SDSL; serine dehydratase like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102488817  SDS; serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102497953  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
tup00010  Glycolysis / Gluconeogenesis
tup00020  Citrate cycle (TCA cycle)
tup00230  Purine metabolism
tup00250  Alanine, aspartate and glutamate metabolism
tup00270  Cysteine and methionine metabolism
tup00290  Valine, leucine and isoleucine biosynthesis
tup00330  Arginine and proline metabolism
tup00470  D-Amino acid metabolism
tup00564  Glycerophospholipid metabolism
tup00600  Sphingolipid metabolism
tup00620  Pyruvate metabolism
tup00630  Glyoxylate and dicarboxylate metabolism
tup00640  Propanoate metabolism
tup00860  Porphyrin metabolism
tup00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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