KEGG   PATHWAY: vko04914
Entry
vko04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Varanus komodoensis (Komodo dragon)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
vko04914  Progesterone-mediated oocyte maturation
vko04914

Other DBs
GO: 0001556
Organism
Varanus komodoensis (Komodo dragon) [GN:vko]
Gene
123031202  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123029047  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
123031035  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123016619  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
123024863  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123025684  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123032363  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123035762  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123022757  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123020010  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
123020058  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
123024287  mitogen-activated protein kinase HOG1-like [KO:K04441] [EC:2.7.11.24]
123034140  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123019948  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123029931  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123035478  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
123029667  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
123021770  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123027333  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
123019207  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
123022135  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123033688  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123025128  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123035427  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123024633  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123036150  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
123035785  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
123017187  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
123027788  CPEB1; cytoplasmic polyadenylation element-binding protein 1 [KO:K02602]
123018503  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
123027902  SPDYA; LOW QUALITY PROTEIN: speedy protein A [KO:K08694]
123033126  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
123018165  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
123022832  CCNA2; cyclin-A2 [KO:K06627]
123029163  CCNA1; cyclin-A1 [KO:K06627]
123020481  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
123026614  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
123030687  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
123030795  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123032171  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123028606  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123021971  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
123018864  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
123029577  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
123025882  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
123032224  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
123031416  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
123027625  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
123035770  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
123034877  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
123017889  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
123022515  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
123034167  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
123021294  INS; insulin [KO:K04526]
123028864  IGF1; insulin-like growth factor I [KO:K05459]
123030778  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123017919  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123026376  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123021030  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123021127  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
123032158  GTPase HRas-like [KO:K07827]
123022284  KRAS; GTPase KRas isoform X1 [KO:K07827]
123024016  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
123028858  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123034069  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
123022876  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
123024962  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
123022904  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
123031062  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
123035375  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
123022831  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
123028203  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
123031772  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123017048  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
123028686  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
123022978  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
123028657  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
123034039  CDC23; cell division cycle protein 23 homolog [KO:K03355]
123023832  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
123018113  ANAPC11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
123035161  CDC26; LOW QUALITY PROTEIN: anaphase-promoting complex subunit CDC26 [KO:K03359]
123025476  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
123017306  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
123018441  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
123032190  KIF22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
vko04010  MAPK signaling pathway
vko04110  Cell cycle
KO pathway
ko04914   
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