KEGG   PATHWAY: vve04148
Entry
vve04148                    Pathway                                
Name
Efferocytosis - Vespa velutina (Asian hornet)
Class
Cellular Processes; Transport and catabolism
Pathway map
vve04148  Efferocytosis
vve04148

Organism
Vespa velutina (Asian hornet) [GN:vve]
Gene
124947253  caspase-1-like isoform X1 [KO:K04397] [EC:3.4.22.60]
124948082  caspase-1-like isoform X1 [KO:K04397] [EC:3.4.22.60]
124954430  sphingosine kinase 2-like isoform X1 [KO:K04718] [EC:2.7.1.91]
124952760  85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
124956652  ADAM 17-like protease [KO:K06059] [EC:3.4.24.86]
124946418  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
124953299  disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
124949768  disintegrin and metalloproteinase domain-containing protein 10-like isoform X1 [KO:K06704] [EC:3.4.24.81]
124948129  uncharacterized protein LOC124948129 isoform X1 [KO:K08268]
124950949  aryl hydrocarbon receptor nuclear translocator homolog isoform X1 [KO:K09097]
124954587  tyrosine-protein kinase hopscotch isoform X1 [KO:K04447] [EC:2.7.10.2]
124953617  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124949166  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
124950107  prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04261]
124949626  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
124948004  calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [KO:K05853] [EC:7.2.2.10]
124951892  calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [KO:K04515] [EC:2.7.11.17]
124957784  mitogen-activated protein kinase p38b-like [KO:K04441] [EC:2.7.11.24]
124951219  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
124946639  dual specificity protein phosphatase Mpk3 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
124948067  anoctamin-4 [KO:K19499]
124950970  XK-related protein 6-like [KO:K26811]
124950037  probable phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
124948541  phospholipid-transporting ATPase IF-like isoform X1 [KO:K26934] [EC:7.6.2.1]
124949334  cell cycle control protein 50A isoform X1 [KO:K26935]
124948353  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
124947171  adapter molecule Crk isoform X1 [KO:K04438]
124952087  engulfment and cell motility protein 1 [KO:K12366]
124955483  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
124952427  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124952625  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124954524  ras-related protein Rac1 [KO:K04392]
124957608  ras-like GTP-binding protein RhoL isoform X1 [KO:K04392]
124952989  calreticulin [KO:K08057]
124947015  protein draper-like isoform X1 [KO:K24068]
124951261  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
124948749  ras-related protein Rab-5B isoform X1 [KO:K07889]
124949951  vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
124957753  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
124953654  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
124951858  vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
124957181  vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
124957910  ras-related protein Rab-14 [KO:K07881]
124948175  vam6/Vps39-like protein [KO:K20183]
124947288  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
124952802  ras-related protein rab7 [KO:K07897]
124957744  arginase-2, mitochondrial-like [KO:K01476] [EC:3.5.3.1]
124957200  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
124957299  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
124957322  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
124957326  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
124957327  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
124957329  ornithine decarboxylase-like isoform X1 [KO:K01581] [EC:4.1.1.17]
124957334  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
124957364  ornithine decarboxylase 1-like isoform X1 [KO:K01581] [EC:4.1.1.17]
124957365  ornithine decarboxylase 1-like isoform X1 [KO:K01581] [EC:4.1.1.17]
124947281  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
124949142  cytochrome b-c1 complex subunit Rieske, mitochondrial-like isoform X1 [KO:K00411] [EC:7.1.1.8]
124950520  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
124957979  NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
124949633  homeobox protein extradenticle isoform X1 [KO:K09355]
124954174  lipase 3-like isoform X1 [KO:K01052] [EC:3.1.1.13]
124948517  lipase 1-like [KO:K01052] [EC:3.1.1.13]
124948966  lipase 3-like [KO:K01052] [EC:3.1.1.13]
124948967  lipase 3-like [KO:K01052] [EC:3.1.1.13]
124949340  phospholipase A2 group XV-like isoform X1 [KO:K06129] [EC:3.1.1.5]
124953933  solute carrier family 2, facilitated glucose transporter member 1-like isoform X1 [KO:K07299]
124954372  glucose transporter type 1 isoform X1 [KO:K07299]
124956319  tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
vve00010  Glycolysis / Gluconeogenesis
vve04140  Autophagy - animal
vve04145  Phagosome
KO pathway
ko04148   
LinkDB

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