KEGG   PATHWAY: zce03040
Entry
zce03040                    Pathway                                
Name
Spliceosome - Zerene cesonia (dogface butterfly)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
zce03040  Spliceosome
zce03040

Other DBs
GO: 0005681
Organism
Zerene cesonia (dogface butterfly) [GN:zce]
Gene
119839145  U1 spliceosomal RNA [KO:K14276]
119833701  U1 spliceosomal RNA [KO:K14276]
119836555  U2 spliceosomal RNA [KO:K14277]
119837723  U2 spliceosomal RNA [KO:K14277]
119837722  U2 spliceosomal RNA [KO:K14277]
119838249  U4 spliceosomal RNA [KO:K14278]
119830600  U4 spliceosomal RNA [KO:K14278]
119829210  U4 spliceosomal RNA [KO:K14278]
119837230  U5 spliceosomal RNA [KO:K14279]
119834737  U5 spliceosomal RNA [KO:K14279]
119832111  U5 spliceosomal RNA [KO:K14279]
119836556  U6 spliceosomal RNA [KO:K14280]
119840052  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
119833546  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
119831170  probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4 [KO:K12813] [EC:5.6.2.6]
119840669  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
119838260  pre-mRNA-processing factor 17 [KO:K12816]
119836632  pre-mRNA-splicing factor 18 [KO:K12817]
119834922  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
119833930  pre-mRNA-splicing factor Slu7 isoform X1 [KO:K12819]
119839000  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
119830428  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
119839357  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
119837926  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
119832618  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
119828164  probable small nuclear ribonucleoprotein E [KO:K11097]
119840685  small nuclear ribonucleoprotein F [KO:K11098]
119837561  probable small nuclear ribonucleoprotein G [KO:K11099]
119838431  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
119840511  U1 small nuclear ribonucleoprotein C [KO:K11095]
119834453  pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
119835967  RNA-binding protein 25-like [KO:K12822]
119840686  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
119840741  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
119828196  ATP-dependent RNA helicase p62-like [KO:K12823] [EC:5.6.2.7]
119828345  ATP-dependent RNA helicase p62-like [KO:K12823] [EC:5.6.2.7]
119838870  transcription elongation regulator 1-like [KO:K12824]
119834852  RNA-binding protein cabeza-like [KO:K13098]
119831455  U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092]
119840785  U1 small nuclear ribonucleoprotein A [KO:K11094]
119838661  splicing factor 3A subunit 1 [KO:K12825]
119838417  splicing factor 3A subunit 3 [KO:K12827]
119834924  splicing factor 3B subunit 1 [KO:K12828]
119828847  splicing factor 3B subunit 2 isoform X1 [KO:K12829]
119828361  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
119830737  splicing factor 3B subunit 4 [KO:K12831]
119836959  splicing factor 3B subunit 5 [KO:K12832]
119829733  splicing factor 3B subunit 6 [KO:K12833]
119838655  PHD finger-like domain-containing protein 5A [KO:K12834]
119838689  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
119834234  splicing factor U2af 38 kDa subunit [KO:K12836]
119829298  survival of motor neuron-related-splicing factor 30-like [KO:K12839]
119829442  survival of motor neuron-related-splicing factor 30-like [KO:K12839]
119829724  splicing factor 45 [KO:K12840]
119831048  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
119838861  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
119838122  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
119839946  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
119838438  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
119832691  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
119836694  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
119839869  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
119837184  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
119838874  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
119838966  LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
119835165  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
119835330  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
119840839  NHP2-like protein 1 [KO:K12845]
119838922  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
119830021  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
119834274  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
119831452  zinc finger matrin-type protein 2 [KO:K12848]
119836668  pre-mRNA-splicing factor 38 [KO:K12849]
119830571  pre-mRNA-splicing factor 38B [KO:K12850]
119830492  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
119839015  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
119840104  pre-mRNA-processing factor 6 [KO:K12855]
119838696  pre-mRNA-processing-splicing factor 8 [KO:K12856]
119840135  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
119829895  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
119834955  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
119840509  cell division cycle 5-like protein [KO:K12860]
119834299  pre-mRNA-splicing factor SPF27 [KO:K12861]
119833947  pleiotropic regulator 1 [KO:K12862]
119830123  protein CWC15 homolog A [KO:K12863]
119829943  beta-catenin-like protein 1 [KO:K12864]
119840567  heat shock 70 kDa protein cognate 4 [KO:K03283]
119836038  heat shock protein 68-like isoform X1 [KO:K03283]
119836210  heat shock protein 68-like [KO:K03283]
119836212  heat shock protein 68-like [KO:K03283]
119831094  heat shock protein 68-like [KO:K03283]
119837646  heat shock protein 68-like [KO:K03283]
119838516  heat shock 70 kDa protein-like [KO:K03283]
119828643  polyglutamine-binding protein 1-like [KO:K12865]
119828644  polyglutamine-binding protein 1 [KO:K12865]
119828256  WW domain-binding protein 11 [KO:K12866]
119836079  puff-specific protein Bx42 isoform X1 [KO:K06063]
119828574  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
119839885  pre-mRNA-splicing factor Syf2 [KO:K12868]
119832859  protein crooked neck [KO:K12869]
119831519  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
119835390  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
119830394  peptidyl-prolyl cis-trans isomerase [KO:K09564] [EC:5.2.1.8]
119838336  coiled-coil domain-containing protein 12 [KO:K12871]
119839540  pre-mRNA-splicing factor RBM22 [KO:K12872]
119832171  protein BUD31 homolog [KO:K12873]
119828403  RNA helicase aquarius [KO:K12874]
119828851  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119836517  RNA-binding protein 8A [KO:K12876]
119830355  protein mago nashi [KO:K12877]
119830384  protein mago nashi [KO:K12877]
119828286  THO complex subunit 1 [KO:K12878]
119833185  THO complex subunit 2 [KO:K12879]
119837771  THO complex subunit 3 [KO:K12880]
119830729  THO complex subunit 4 [KO:K12881]
119839801  nuclear cap-binding protein subunit 1 [KO:K12882]
119830037  nuclear cap-binding protein subunit 2 [KO:K12883]
119836069  heterogeneous nuclear ribonucleoprotein 87F-like [KO:K12741]
119838608  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
119831685  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
119835045  serine/arginine-rich splicing factor 1B [KO:K12890]
119832210  serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
119829121  serine-arginine protein 55-like isoform X1 [KO:K12893]
119834383  serine/arginine-rich splicing factor 7-like [KO:K12896]
119830336  RNA-binding protein 1-like isoform X1 [KO:K12896]
119838637  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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