KEGG   PATHWAY: pcoq04514
Entry
pcoq04514                   Pathway                                
Name
Cell adhesion molecules - Propithecus coquereli (Coquerel's sifaka)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pcoq04514  Cell adhesion molecules
pcoq04514

Other DBs
GO: 0050839
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105805024  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
105805508  CNTN1; contactin-1 isoform X1 [KO:K06759]
105805555  VCAN; versican core protein isoform X1 [KO:K06793]
105805854  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
105805885  NRXN1; LOW QUALITY PROTEIN: neurexin-1-beta [KO:K07377]
105806221  SIGLEC1; sialoadhesin [KO:K06548]
105806381  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
105806415  MPZ; myelin protein P0 [KO:K06770]
105806444  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
105806462  F11R; junctional adhesion molecule A [KO:K06089]
105806510  NTNG2; netrin-G2 [KO:K16359]
105806705  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
105806724  NEGR1; neuronal growth regulator 1 [KO:K06775]
105806899  CLDN14; claudin-14 [KO:K06087]
105806917  JAM2; junctional adhesion molecule B [KO:K06735]
105806944  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
105806974  CLDN11; claudin-11 isoform X1 [KO:K06087]
105807081  CLDN4; claudin-4 [KO:K06087]
105807086  CLDN3; claudin-3 [KO:K06087]
105807125  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
105807234  NEO1; neogenin [KO:K06766]
105807303  CD276; CD276 antigen [KO:K06746]
105807824  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
105807825  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105807974  GLG1; Golgi apparatus protein 1 [KO:K06816]
105808206  CDH2; cadherin-2 isoform X1 [KO:K06736]
105808525  ITGB1; integrin beta-1 [KO:K05719]
105808648  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
105808654  SDC3; syndecan-3 [KO:K16337]
105808709  CLDN1; claudin-1 [KO:K06087]
105809029  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
105809220  CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
105809336  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
105809714  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
105809772  SDC2; syndecan-2 [KO:K16336]
105810066  CD6; T-cell differentiation antigen CD6 [KO:K06456]
105810148  [KO:K06752]
105810260  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
105810265  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
105810317  JAM3; junctional adhesion molecule C [KO:K06785]
105810871  PVRL1; nectin-1 isoform X1 [KO:K06081]
105811243  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
105811483  CLDN2; claudin-2 [KO:K06087]
105811731  ALCAM; CD166 antigen [KO:K06547]
105811974  PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
105812313  CLDN19; claudin-19 isoform X1 [KO:K06087]
105812404  CLDN20; claudin-20 [KO:K06087]
105812779  CLDN10; claudin-10 isoform X1 [KO:K06087]
105812816  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
105812828  PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
105812832  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
105812837  CD274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]
105813135  CLDN6; claudin-6 [KO:K06087]
105813136  CLDN9; claudin-9 [KO:K06087]
105813623  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
105813630  SLITRK5; SLIT and NTRK-like protein 5 isoform X1 [KO:K25836]
105813735  NTNG1; netrin-G1 isoform X1 [KO:K07522]
105814093  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
105814175  [KO:K10784]
105814229  CLDN34; claudin 34 [KO:K06087]
105814744  CLDN23; claudin-23 [KO:K06087]
105815219  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
105815308  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
105815600  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105815884  ITGA4; integrin alpha-4 [KO:K06483]
105816208  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
105816209  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
105816727  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
105817083  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
105817268  [KO:K06751]
105817288  [KO:K06751]
105817290  [KO:K06751]
105817294  [KO:K06751]
105817414  SDC1; syndecan-1 [KO:K06257]
105817526  PVR; poliovirus receptor [KO:K06539]
105817700  PVRL2; nectin-2 isoform X1 [KO:K06531]
105817835  [KO:K06752]
105817846  [KO:K06751]
105817910  [KO:K06751]
105817913  [KO:K06752]
105817935  [KO:K06590]
105818527  CDH4; cadherin-4 [KO:K06797]
105818793  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
105818840  CLDN5; claudin-5 [KO:K06087]
105819099  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
105819124  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
105819142  ICOS; inducible T-cell costimulator [KO:K06713]
105819153  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
105819207  AMICA1; junctional adhesion molecule-like [KO:K28137]
105819267  CD40LG; CD40 ligand isoform X1 [KO:K03161]
105819427  CLDN7; claudin-7 [KO:K06087]
105819473  NLGN2; neuroligin-2 [KO:K07378]
105819766  [KO:K07377]
105820096  [KO:K06592]
105820215  CNTNAP1; contactin-associated protein 1 [KO:K07379]
105820349  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
105820350  [KO:K06520]
105820633  CDH15; cadherin-15 [KO:K06809]
105820798  CLDN8; claudin-8 [KO:K06087]
105820812  CLDN17; claudin-17 [KO:K06087]
105820890  CLDN22; claudin-22 [KO:K06087]
105820894  CLDN24; putative claudin-24 [KO:K06087]
105820985  CD226; CD226 antigen [KO:K06567]
105820994  SELPLG; LOW QUALITY PROTEIN: P-selectin glycoprotein ligand 1 [KO:K06544]
105821104  SELP; P-selectin [KO:K06496]
105821108  SELE; E-selectin [KO:K06494]
105821134  SELL; L-selectin [KO:K06495]
105821185  NFASC; neurofascin isoform X1 [KO:K06757]
105821188  CNTN2; contactin-2 [KO:K06760]
105821267  SDC4; syndecan-4 [KO:K16338]
105821628  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
105821698  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
105821699  CD2; T-cell surface antigen CD2 [KO:K06449]
105822246  CLDN25; putative claudin-25 [KO:K06087]
105822247  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
105822255  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
105822435  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105823085  [KO:K06461]
105823192  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105823213  SPN; leukosialin [KO:K06477]
105823322  CDH3; cadherin-3 [KO:K06796]
105823410  CDH1; cadherin-1 [KO:K05689]
105823420  CDH5; cadherin-5 [KO:K06533]
105823544  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
105823606  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
105823658  ITGA8; integrin alpha-8 [KO:K06584]
105824154  ICOSLG; ICOS ligand [KO:K06710]
105824372  [KO:K06752]
105824381  [KO:K06752]
105824383  [KO:K06752]
105824384  [KO:K06752]
105824385  [KO:K06752]
105824386  [KO:K06752]
105824388  [KO:K06752]
105824389  [KO:K06752]
105824475  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
105824487  PDCD1; LOW QUALITY PROTEIN: programmed cell death protein 1 [KO:K06744]
105824546  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
105824583  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
105825103  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
105825301  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
105825468  [KO:K23268]
105825770  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105826002  CLDN18; claudin-18 isoform X1 [KO:K06087]
105826040  CLDN15; claudin-15 [KO:K06087]
105826047  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
105826393  [KO:K06087]
105826394  [KO:K06087]
105826638  OCLN; occludin [KO:K06088]
105826746  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
105827191  NRXN2; neurexin-2-beta isoform X1 [KO:K07377]
105827230  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
105827233  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
105827543  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
pcoq04520  Adherens junction
pcoq04530  Tight junction
pcoq04610  Complement and coagulation cascades
pcoq04660  T cell receptor signaling pathway
pcoq04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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