KEGG   PATHWAY: pga00260
Entry
pga00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Phaeobacter inhibens DSM 17395
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pga00260  Glycine, serine and threonine metabolism
pga00260

Module
pga_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pga00260]
pga_M00555  Betaine biosynthesis, choline => betaine [PATH:pga00260]
pga_M00621  Glycine cleavage system [PATH:pga00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Phaeobacter inhibens DSM 17395 [GN:pga]
Gene
PGA1_c23510  lysC; aspartokinase LysC [KO:K00928] [EC:2.7.2.4]
PGA1_c31480  asd; aspartate-semialdehyde dehydrogenase Asd [KO:K00133] [EC:1.2.1.11]
PGA1_c08650  hom; homoserine dehydrogenase Hom [KO:K00003] [EC:1.1.1.3]
PGA1_c06310  thrC; threonine synthase ThrC [KO:K01733] [EC:4.2.3.1]
PGA1_c25010  ltaE; low specificity L-threonine aldolase LtaE [KO:K01620] [EC:4.1.2.48]
PGA1_c24580  putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PGA1_c11870  glyA; serine hydroxymethyltransferase GlyA [KO:K00600] [EC:2.1.2.1]
PGA1_c23940  putative serine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PGA1_c26570  putative glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
PGA1_c31360  putative hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
PGA1_c02770  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GpmI [KO:K15633] [EC:5.4.2.12]
PGA1_c36140  serA; D-3-phosphoglycerate dehydrogenase SerA [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PGA1_c36150  serC; phosphoserine aminotransferase SerC [KO:K00831] [EC:2.6.1.52]
PGA1_c36160  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
PGA1_c34330  kbl; 2-amino-3-ketobutyrate coenzyme A ligase Kbl [KO:K00639] [EC:2.3.1.29]
PGA1_c34320  tdh; L-threonine 3-dehydrogenase Tdh [KO:K00060] [EC:1.1.1.103]
PGA1_c20350  hemA; 5-aminolevulinate synthase HemA [KO:K00643] [EC:2.3.1.37]
PGA1_78p00310  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PGA1_78p00290  gcvT; aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
PGA1_c03550  lpd2; dihydrolipoyl dehydrogenase 2 [KO:K00382] [EC:1.8.1.4]
PGA1_c17390  lpdA2; dihydrolipoyl dehydrogenase LpdA [KO:K00382] [EC:1.8.1.4]
PGA1_78p00260  lpdA; dihydrolipoyl dehydrogenase LpdA [KO:K00382] [EC:1.8.1.4]
PGA1_c23190  lpdA3; dihydrolipoyl dehydrogenase LpdA [KO:K00382] [EC:1.8.1.4]
PGA1_c05560  gcvH; glycine cleavage system protein GcvH [KO:K02437]
PGA1_78p00300  gcvH; glycine cleavage system protein GcvH [KO:K02437]
PGA1_c29630  creatinase [KO:K08688] [EC:3.5.3.3]
PGA1_c29620  putative CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
PGA1_c21660  betA; choline dehydrogenase BetA [KO:K00108] [EC:1.1.99.1]
PGA1_c21670  betB2; betaine aldehyde dehydrogenase BetB [KO:K00130] [EC:1.2.1.8]
PGA1_c33130  dmgdH4; dimethylglycine dehydrogenase DmgdH [KO:K00315] [EC:1.5.8.4]
PGA1_262p01400  dmgdH; dimethylglycine dehydrogenase DmgdH [KO:K00315] [EC:1.5.8.4]
PGA1_c25540  dmgdH2; dimethylglycine dehydrogenase DmgdH [KO:K00315] [EC:1.5.8.4]
PGA1_c28230  dmgdH3; dimethylglycine dehydrogenase DmgdH [KO:K00315] [EC:1.5.8.4]
PGA1_c14040  dmgdH1; dimethylglycine dehydrogenase DmgdH [KO:K00315] [EC:1.5.8.4]
PGA1_c19150  soxA3; sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PGA1_c19170  soxB3; sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PGA1_c19140  sarcosine oxidase-like protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PGA1_c19160  soxD3; sarcosine oxidase 2 subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PGA1_c23770  tdcG; L-serine dehydratase TdcG [KO:K01752] [EC:4.3.1.17]
PGA1_c04590  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PGA1_c34900  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
PGA1_c36290  putative phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
PGA1_c04930  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PGA1_c04870  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
PGA1_c07820  putative peptidase M22 [KO:K15783] [EC:3.5.4.44]
PGA1_c07810  aminotransferase class-III [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pga00010  Glycolysis / Gluconeogenesis
pga00020  Citrate cycle (TCA cycle)
pga00230  Purine metabolism
pga00250  Alanine, aspartate and glutamate metabolism
pga00270  Cysteine and methionine metabolism
pga00290  Valine, leucine and isoleucine biosynthesis
pga00300  Lysine biosynthesis
pga00330  Arginine and proline metabolism
pga00460  Cyanoamino acid metabolism
pga00470  D-Amino acid metabolism
pga00564  Glycerophospholipid metabolism
pga00600  Sphingolipid metabolism
pga00620  Pyruvate metabolism
pga00630  Glyoxylate and dicarboxylate metabolism
pga00640  Propanoate metabolism
pga00680  Methane metabolism
pga00860  Porphyrin metabolism
pga00920  Sulfur metabolism
KO pathway
ko00260   
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