Entry Name Folate transport and metabolism - Peromyscus leucopus (white-footed mouse)
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114683322 Abcc5; multidrug resistance-associated protein 5 isoform X1 [KO:K05668 ]
114683637 Slc22a8; LOW QUALITY PROTEIN: solute carrier family 22 member 8 [KO:K08205 ]
114692883 Abcc3; canalicular multispecific organic anion transporter 2 [KO:K05667 ]
114698704 Slco2b1; solute carrier organic anion transporter family member 2B1 [KO:K14352 ]
114706437 Abcc2; canalicular multispecific organic anion transporter 1 [KO:K05666 ]
114709673 Mthfr; methylenetetrahydrofolate reductase isoform X1 [KO:K25004 ]
Compound C00019 S-Adenosyl-L-methionine
C00021 S-Adenosyl-L-homocysteine
C00143 5,10-Methylenetetrahydrofolate
C00440 5-Methyltetrahydrofolate
C00445 5,10-Methenyltetrahydrofolate
Reference Authors Alam C, Kondo M, O'Connor DL, Bendayan R
Title Clinical Implications of Folate Transport in the Central Nervous System.
Journal Reference Authors Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K
Title Folic acid inhibits 5-methyltetrahydrofolate transport across the blood-cerebrospinal fluid barrier: Clinical biochemical data from two cases.
Journal Reference Authors Visentin M, Diop-Bove N, Zhao R, Goldman ID
Title The intestinal absorption of folates.
Journal Reference Authors Ledowsky C, Mahimbo A, Scarf V, Steel A
Title Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review.
Journal Reference Authors Zarou MM, Vazquez A, Vignir Helgason G
Title Folate metabolism: a re-emerging therapeutic target in haematological cancers.
Journal Reference Authors Bekdash RA
Title Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.
Journal Reference Authors Steinfeld R, Grapp M, Kraetzner R, Dreha-Kulaczewski S, Helms G, Dechent P, Wevers R, Grosso S, Gartner J
Title Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.
Journal Reference Authors Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J
Title The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.
Journal Reference Authors Shulpekova Y, Nechaev V, Kardasheva S, Sedova A, Kurbatova A, Bueverova E, Kopylov A, Malsagova K, Dlamini JC, Ivashkin V
Title The Concept of Folic Acid in Health and Disease.
Journal Reference Authors Mafi S, Laroche-Raynaud C, Chazelas P, Lia AS, Derouault P, Sturtz F, Baaj Y, Froget R, Rio M, Benoist JF, Poumeaud F, Favreau F, Faye PA
Title Pharmacoresistant Epilepsy in Childhood: Think of the Cerebral Folate Deficiency, a Treatable Disease.
Journal Related KO pathway
