KEGG   PATHWAY: pleu04144
Entry
pleu04144                   Pathway                                
Name
Endocytosis - Peromyscus leucopus (white-footed mouse)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pleu04144  Endocytosis
pleu04144

Other DBs
GO: 0006897
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680599  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X2 [KO:K12182]
114680628  Chmp6; charged multivesicular body protein 6 [KO:K12195]
114680960  Rab7a; ras-related protein Rab-7a [KO:K07897]
114681065  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
114681107  Ehd4; EH domain-containing protein 4 [KO:K12477]
114681242  Iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
114681253  Rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
114681340  Git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
114681427  Ehd2; EH domain-containing protein 2 [KO:K12469]
114681438  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
114681447  Rbsn; rabenosyn-5 [KO:K12481]
114681488  Rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
114681738  Rab5b; ras-related protein Rab-5B [KO:K07888]
114681810  Rnf41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
114681830  [KO:K12190]
114681835  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114682074  Ehd1; EH domain-containing protein 1 [KO:K12483]
114682123  Mvb12a; multivesicular body subunit 12A isoform X1 [KO:K12186]
114682164  Zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
114682362  Chmp1b; charged multivesicular body protein 1b [KO:K12197]
114682379  Vps45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
114682468  Rab4a; ras-related protein Rab-4A [KO:K07879]
114682611  Rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
114682635  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X3 [KO:K13305] [EC:2.3.2.26]
114682640  [KO:K06751]
114682644  [KO:K06751]
114682645  [KO:K06751]
114682649  [KO:K06751]
114682653  [KO:K06751]
114682654  [KO:K06751]
114682655  [KO:K06751]
114682656  [KO:K06751]
114682666  [KO:K06751]
114682671  [KO:K06751]
114682672  [KO:K06751]
114682673  [KO:K06751]
114682677  [KO:K06751]
114682685  [KO:K06751]
114682688  [KO:K06751]
114682752  Arfgap3; LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
114682779  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
114682792  Rab5c; ras-related protein Rab-5C [KO:K07889]
114682822  Vps25; vacuolar protein-sorting-associated protein 25 isoform X1 [KO:K12189]
114682984  Arf1; ADP-ribosylation factor 1 [KO:K07937]
114683196  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
114683287  Epn2; epsin-2 isoform X1 [KO:K12471]
114683309  Ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
114683401  Iqsec2; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
114683424  Vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
114683759  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
114684268  Arf6; ADP-ribosylation factor 6 [KO:K07941]
114684308  Grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
114684332  Ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
114684719  Cyth2; cytohesin-2 isoform X1 [KO:K18441]
114684789  Epn1; epsin-1 isoform X1 [KO:K12471]
114685083  Sh3gl1; endophilin-A2 [KO:K11247]
114685127  [KO:K02833]
114685319  Rab11b; ras-related protein Rab-11B [KO:K07905]
114685390  Tfrc; LOW QUALITY PROTEIN: transferrin receptor protein 1 [KO:K06503]
114685555  Rab11fip5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
114685586  Chmp3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
114685634  Tsg101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
114685666  Amph; amphiphysin [KO:K12562]
114685988  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
114686018  Vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
114686123  Grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
114686261  Vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
114686275  [KO:K12197]
114686335  Rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
114686366  [KO:K06751]
114686558  Sh3glb1; endophilin-B1 isoform X1 [KO:K11248]
114686806  Rab11fip1; LOW QUALITY PROTEIN: rab11 family-interacting protein 1 [KO:K12484]
114686840  Vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
114686934  [KO:K03283]
114687018  [KO:K06751]
114687019  [KO:K06751]
114687020  [KO:K06751]
114687550  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
114687553  Arrb2; beta-arrestin-2 [KO:K04439]
114687933  [KO:K06751]
114687935  [KO:K06751]
114688360  Pip5k1c; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
114688482  [KO:K06751]
114688488  [KO:K02833]
114688490  [KO:K06751]
114688492  [KO:K06751]
114688645  [KO:K11866] [EC:3.4.19.12]
114688790  [KO:K06751]
114688816  [KO:K06751]
114688817  [KO:K06751]
114689175  Grk6; G protein-coupled receptor kinase 6 isoform X2 [KO:K08291] [EC:2.7.11.16]
114689359  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114689461  Cltb; clathrin light chain B isoform X1 [KO:K04645]
114689585  Cav3; caveolin-3 [KO:K12959]
114689606  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
114689647  Washc2c; WASH complex subunit 2C isoform X1 [KO:K18462]
114689719  Wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
114689964  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
114690029  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
114690100  Arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
114690425  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
114690610  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
114690920  [KO:K04674] [EC:2.7.11.30]
114691098  Arf5; ADP-ribosylation factor 5 [KO:K07940]
114691135  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
114691162  Cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
114691166  Snx1; sorting nexin-1 isoform X1 [KO:K17917]
114691291  Spg21; LOW QUALITY PROTEIN: maspardin [KO:K19367]
114691309  [KO:K04393]
114691369  Igf2r; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564]
114691460  Rab11a; ras-related protein Rab-11A isoform X2 [KO:K07904]
114691471  Git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
114691530  Rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
114691539  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
114691639  Bin1; myc box-dependent-interacting protein 1 isoform X2 [KO:K12562]
114691745  [KO:K04674] [EC:2.7.11.30]
114691911  Cblb; E3 ubiquitin-protein ligase CBL-B isoform X2 [KO:K22517] [EC:2.3.2.27]
114692321  Smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
114692385  Fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
114692417  Arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
114692654  Arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
114692673  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
114692752  Psd4; PH and SEC7 domain-containing protein 4 [KO:K12494]
114692888  Epn3; epsin-3 isoform X1 [KO:K12471]
114692922  Snf8; vacuolar-sorting protein SNF8 [KO:K12188]
114693194  Acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
114693314  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114693368  Snx6; sorting nexin-6 isoform X1 [KO:K17920]
114693493  [KO:K02833]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693729  Dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
114693867  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
114693935  Stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
114694056  Fgfr3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
114694079  Grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
114694185  Vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
114694232  Cyth4; cytohesin-4 isoform X1 [KO:K18441]
114694353  Il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
114694405  [KO:K11866] [EC:3.4.19.12]
114694720  Capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
114694722  Cav1; caveolin-1 [KO:K06278]
114694723  Cav2; caveolin-2 [KO:K12958]
114694777  Snx2; sorting nexin-2 isoform X1 [KO:K17917]
114694804  Washc5; WASH complex subunit 5 [KO:K18464]
114694883  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
114694904  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
114695063  Capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
114695144  Vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
114695226  Dnm2; dynamin-2 isoform X1 [KO:K23484]
114695236  Ldlr; low-density lipoprotein receptor [KO:K12473]
114695317  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
114695462  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114695594  Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
114695621  Kif5b; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
114695792  Sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
114695877  Spart; LOW QUALITY PROTEIN: spartin [KO:K19366]
114696119  Ehd3; EH domain-containing protein 3 isoform X1 [KO:K12476]
114696221  Sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
114696314  Washc1; WASH complex subunit 1 [KO:K18461]
114696321  Rab31; ras-related protein Rab-31 [KO:K07891]
114696475  Rab10; ras-related protein Rab-10 isoform X1 [KO:K07903]
114696553  [KO:K02833]
114696754  Psd; PH and SEC7 domain-containing protein 1 [KO:K12494]
114696759  Gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
114696943  Actr3; actin-related protein 3 [KO:K18584]
114696964  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
114697177  Capzb; F-actin-capping protein subunit beta isoform X5 [KO:K10365]
114697206  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114697222  Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
114697251  Ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
114697343  Dab2; disabled homolog 2 isoform X1 [KO:K12475]
114697539  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
114697727  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
114698310  Stam2; signal transducing adapter molecule 2 [KO:K04705]
114698703  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
114698740  Arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
114698861  Asap2; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
114699278  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
114699690  Arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
114699928  Kif5c; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
114700059  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
114700079  Agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3 [KO:K12491]
114700642  Washc3; WASH complex subunit 3 isoform X1 [KO:K18463]
114700698  Agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
114700727  Iqsec3; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
114700831  Wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
114700910  [KO:K04513]
114700994  Chmp1a; charged multivesicular body protein 1a [KO:K12197]
114701067  Rab11fip2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
114701131  Rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
114701205  Eea1; LOW QUALITY PROTEIN: early endosome antigen 1 [KO:K12478]
114701214  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
114701275  [KO:K04393]
114702131  Arf4; ADP-ribosylation factor 4 [KO:K07939]
114702274  [KO:K07937]
114702344  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
114702588  Vps26b; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 26B [KO:K18466]
114702689  Chmp7; charged multivesicular body protein 7 [KO:K15053]
114702731  Sh3glb2; endophilin-B2 isoform X1 [KO:K21269]
114702807  Vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
114702920  [KO:K12183]
114702992  Washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
114703123  Psd3; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 3 [KO:K12494]
114703254  Chmp5; charged multivesicular body protein 5 [KO:K12198]
114703416  Vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
114703682  Actr2; actin-related protein 2 isoform X3 [KO:K17260]
114703797  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
114703804  Pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
114703892  Chmp2a; charged multivesicular body protein 2a [KO:K12191]
114704115  Wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
114704187  Arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
114704529  Vps37b; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 37B [KO:K12185]
114704562  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
114704565  Vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
114704687  Mvb12b; multivesicular body subunit 12B isoform X1 [KO:K12186]
114704762  Vps26a; vacuolar protein sorting-associated protein 26A isoform X2 [KO:K18466]
114704803  Kif5a; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
114704813  Agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K17848]
114704853  Snx4; LOW QUALITY PROTEIN: sorting nexin-4 [KO:K17919]
114704894  [KO:K12197]
114704921  Smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
114704977  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114705093  Psd2; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 2 [KO:K12494]
114705216  Rhoa; transforming protein RhoA [KO:K04513]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114705623  Chmp4c; charged multivesicular body protein 4c [KO:K24782]
114705715  [KO:K12492]
114705775  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
114705846  [KO:K06751]
114705867  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
114705868  [KO:K03283]
114705870  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
114706315  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
114706435  Zfyve27; protrudin isoform X1 [KO:K19368]
114706483  Eps15; epidermal growth factor receptor substrate 15 isoform X2 [KO:K12472]
114706511  Chmp4b; charged multivesicular body protein 4b [KO:K12194]
114706546  Itch; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
114706605  [KO:K13649]
114706689  [KO:K13649]
114706910  Wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
114707267  Capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
114707466  Rab5a; ras-related protein Rab-5A [KO:K07887]
114707505  Snx3; sorting nexin-3 isoform X1 [KO:K17918]
114707541  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
114707559  Cyth3; cytohesin-3 isoform X1 [KO:K18441]
114707564  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
114707571  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
114707711  Ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
114708055  Ist1; IST1 homolog isoform X1 [KO:K19476]
114708277  Prkcz; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
114708291  Acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X3 [KO:K12489]
114708521  Arf3; ADP-ribosylation factor 3 [KO:K07938]
114708654  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
114708663  Snx12; sorting nexin-12 [KO:K17918]
114708729  Chmp4a; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194]
114708790  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
114708922  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
114708971  Cyth1; cytohesin-1 isoform X1 [KO:K18441]
114709042  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
114709057  Usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
114709153  Snx32; sorting nexin-32 [KO:K17920]
114709262  [KO:K12200]
114709280  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
114709324  [KO:K05050]
114709325  [KO:K04175]
114709414  Snx5; sorting nexin-5 [KO:K17920]
114709420  [KO:K18466]
114709578  Rab8a; ras-related protein Rab-8A isoform X2 [KO:K07901]
114709608  Eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X2 [KO:K12472]
114709811  Rab22a; ras-related protein Rab-22A [KO:K07891]
114709869  Cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
114709955  Vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
114710028  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
114710035  Acap2; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
114710579  Clta; clathrin light chain A isoform X1 [KO:K04644]
114710709  [KO:K12193]
114710754  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pleu04060  Cytokine-cytokine receptor interaction
pleu04070  Phosphatidylinositol signaling system
pleu04130  SNARE interactions in vesicular transport
pleu04142  Lysosome biogenesis
pleu04350  TGF-beta signaling pathway
KO pathway
ko04144   

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