KEGG   PATHWAY: ppad00330
Entry
ppad00330                   Pathway                                
Name
Arginine and proline metabolism - Panthera pardus (leopard)
Class
Metabolism; Amino acid metabolism
Pathway map
ppad00330  Arginine and proline metabolism
ppad00330

Module
ppad_M00015  Proline biosynthesis, glutamate => proline [PATH:ppad00330]
ppad_M00047  Creatine pathway [PATH:ppad00330]
ppad_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:ppad00330]
ppad_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:ppad00330]
ppad_M00970  Proline degradation, proline => glutamate [PATH:ppad00330]
ppad_M00972  Proline metabolism [PATH:ppad00330]
Other DBs
GO: 0006525 0006560
Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109263041  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
109257654  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
109257767  creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
109263076  creatine kinase U-type, mitochondrial isoform X1 [KO:K00933] [EC:2.7.3.2]
109274914  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
109253241  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
109255302  AZIN2; antizyme inhibitor 2 isoform X1 [KO:K01583] [EC:4.1.1.19]
109268677  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
109255238  antizyme inhibitor 2-like [KO:K01581] [EC:4.1.1.17]
109274102  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
109257443  SMS; spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
109263542  AMD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
109252362  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
109274753  SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
109270117  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
109245801  ALDH3A2; fatty aldehyde dehydrogenase isoform X1 [KO:K00128] [EC:1.2.1.3]
109277644  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
109253061  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
109250945  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
109276686  4-trimethylaminobutyraldehyde dehydrogenase-like [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109276687  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
109251775  CNDP1; beta-Ala-His dipeptidase [KO:K05604] [EC:3.4.13.20]
109251777  CNDP2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
109246848  CARNS1; carnosine synthase 1 isoform X1 [KO:K14755] [EC:6.3.2.11]
109245938  SAT2; diamine acetyltransferase 2 [KO:K00657] [EC:2.3.1.57]
109257452  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
109248044  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
109248045  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
109274158  AGMAT; agmatinase, mitochondrial isoform X1 [KO:K27001] [EC:3.5.3.- 3.5.3.7 3.5.3.17]
109277571  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
109251875  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
109252365  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
109268279  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
109249932  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
109252305  OAT; ornithine aminotransferase, mitochondrial isoform X1 [KO:K00819] [EC:2.6.1.13]
109258358  PYCRL; pyrroline-5-carboxylate reductase 3 isoform X1 [KO:K00286] [EC:1.5.1.2]
109250834  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
109276762  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1 [KO:K00286] [EC:1.5.1.2]
109258611  proline dehydrogenase 1, mitochondrial isoform X1 [KO:K00318] [EC:1.5.5.2]
109274209  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
109264691  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
109269617  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
109267184  P4HA3; prolyl 4-hydroxylase subunit alpha-3 isoform X1 [KO:K00472] [EC:1.14.11.2]
109264400  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
109250897  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
109251455  PRODH2; probable proline dehydrogenase 2 isoform X1 [KO:K11394] [EC:1.5.5.3]
109272750  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
109262315  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
109270834  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
109272717  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1 [KO:K18123] [EC:4.1.3.16]
109277485  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
109268398  L3HYPDH; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
ppad00020  Citrate cycle (TCA cycle)
ppad00220  Arginine biosynthesis
ppad00250  Alanine, aspartate and glutamate metabolism
ppad00260  Glycine, serine and threonine metabolism
ppad00270  Cysteine and methionine metabolism
ppad00310  Lysine degradation
ppad00410  beta-Alanine metabolism
ppad00470  D-Amino acid metabolism
ppad00480  Glutathione metabolism
ppad00630  Glyoxylate and dicarboxylate metabolism
ppad00650  Butanoate metabolism
ppad00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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