KEGG   PATHWAY: ppel00260
Entry
ppel00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudonocardia petroleophila
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ppel00260  Glycine, serine and threonine metabolism
ppel00260

Module
ppel_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ppel00260]
ppel_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ppel00260]
ppel_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:ppel00260]
ppel_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ppel00260]
ppel_M00555  Betaine biosynthesis, choline => betaine [PATH:ppel00260]
ppel_M00621  Glycine cleavage system [PATH:ppel00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudonocardia petroleophila [GN:ppel]
Gene
H6H00_06590  aspartate kinase [KO:K00928] [EC:2.7.2.4]
H6H00_06585  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
H6H00_13855  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
H6H00_13865  homoserine kinase [KO:K00872] [EC:2.7.1.39]
H6H00_13860  threonine synthase [KO:K01733] [EC:4.2.3.1]
H6H00_16025  threonine synthase [KO:K01733] [EC:4.2.3.1]
H6H00_17835  threonine synthase [KO:K01733] [EC:4.2.3.1]
H6H00_06215  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01620] [EC:4.1.2.48]
H6H00_13905  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
H6H00_17700  glycerate kinase [KO:K00865] [EC:2.7.1.165]
H6H00_24870  glycerate kinase [KO:K00865] [EC:2.7.1.165]
H6H00_11205  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
H6H00_10365  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
H6H00_14590  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
H6H00_05260  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
H6H00_00635  HAD-IB family phosphatase [KO:K01079] [EC:3.1.3.3]
H6H00_02510  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
H6H00_30280  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
H6H00_07355  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
H6H00_24015  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
H6H00_17665  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
H6H00_14460  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
H6H00_17645  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
H6H00_24040  gcvH; glycine cleavage system protein GcvH [KO:K02437]
H6H00_10840  phosphatidylcholine/phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
H6H00_15100  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
H6H00_30510  GMC family oxidoreductase N-terminal domain-containing protein [KO:K17755] [EC:1.1.3.17]
H6H00_30320  aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
H6H00_30520  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
H6H00_30545  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
H6H00_30540  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
H6H00_04060  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
H6H00_25905  cysteine synthase family protein [KO:K01697] [EC:4.2.1.22]
H6H00_14775  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
H6H00_30600  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
H6H00_00840  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
H6H00_04025  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
H6H00_27180  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
H6H00_27185  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
H6H00_22880  TrpB-like pyridoxal phosphate-dependent enzyme [KO:K06001] [EC:4.2.1.20]
H6H00_10585  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
H6H00_26510  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
H6H00_10580  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
H6H00_10590  ectoine synthase [KO:K06720] [EC:4.2.1.108]
H6H00_26505  ectoine synthase [KO:K06720] [EC:4.2.1.108]
H6H00_10595  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
H6H00_26500  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ppel00010  Glycolysis / Gluconeogenesis
ppel00020  Citrate cycle (TCA cycle)
ppel00230  Purine metabolism
ppel00250  Alanine, aspartate and glutamate metabolism
ppel00270  Cysteine and methionine metabolism
ppel00290  Valine, leucine and isoleucine biosynthesis
ppel00300  Lysine biosynthesis
ppel00330  Arginine and proline metabolism
ppel00460  Cyanoamino acid metabolism
ppel00470  D-Amino acid metabolism
ppel00564  Glycerophospholipid metabolism
ppel00620  Pyruvate metabolism
ppel00630  Glyoxylate and dicarboxylate metabolism
ppel00640  Propanoate metabolism
ppel00680  Methane metabolism
ppel00860  Porphyrin metabolism
ppel00920  Sulfur metabolism
KO pathway
ko00260   
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