KEGG   PATHWAY: pre00260
Entry
pre00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Metapseudomonas resinovorans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pre00260  Glycine, serine and threonine metabolism
pre00260

Module
pre_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pre00260]
pre_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pre00260]
pre_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pre00260]
pre_M00555  Betaine biosynthesis, choline => betaine [PATH:pre00260]
pre_M00621  Glycine cleavage system [PATH:pre00260]
pre_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pre00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Metapseudomonas resinovorans [GN:pre]
Gene
PCA10_00320  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
PCA10_00330  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
PCA10_00710  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
PCA10_03010  [KO:K01697] [EC:4.2.1.22]
PCA10_03020  [KO:K01758] [EC:4.4.1.1]
PCA10_03120  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PCA10_03270  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PCA10_03520  [KO:K00274] [EC:1.4.3.4]
PCA10_03930  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PCA10_03940  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PCA10_04030  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PCA10_04060  [KO:K25961]
PCA10_04070  [KO:K25960]
PCA10_04080  dgcB; dimethylglycine catabolism protein DgcB [KO:K21834]
PCA10_04090  dgcA; dimethylglycine catabolism protein DgcA [KO:K21833] [EC:1.5.7.3]
PCA10_04310  [KO:K00479] [EC:1.14.13.251]
PCA10_04320  [KO:K21832] [EC:1.14.13.251]
PCA10_04350  ltaE; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
PCA10_04400  [KO:K08688] [EC:3.5.3.3]
PCA10_04430  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PCA10_04440  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PCA10_04450  soxD; sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PCA10_04460  soxA; sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PCA10_04470  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PCA10_08540  [KO:K00130] [EC:1.2.1.8]
PCA10_09050  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PCA10_14210  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PCA10_14220  soxA; sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PCA10_14230  soxD; sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PCA10_14240  soxB; sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PCA10_14380  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PCA10_14420  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PCA10_16020  [KO:K00865] [EC:2.7.1.165]
PCA10_16950  [KO:K00130] [EC:1.2.1.8]
PCA10_19090  [KO:K11529] [EC:2.7.1.165]
PCA10_20100  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PCA10_21700  lpd; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PCA10_24300  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PCA10_24670  lpd; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
PCA10_30790  pvdH; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
PCA10_31600  gcvH; glycine cleavage system H protein [KO:K02437]
PCA10_31610  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PCA10_31620  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PCA10_31630  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PCA10_32870  thrH; phosphoserine:homoserine phosphotransferase [KO:K02203] [EC:3.1.3.3 2.7.1.39]
PCA10_36240  [KO:K00130] [EC:1.2.1.8]
PCA10_39180  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
PCA10_42330  lysC; aspartokinase [KO:K00928] [EC:2.7.2.4]
PCA10_42350  [KO:K01620] [EC:4.1.2.48]
PCA10_43370  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PCA10_43440  gcvH; glycine cleavage system H protein [KO:K02437]
PCA10_43450  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PCA10_43460  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PCA10_43470  sdaA; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
PCA10_43480  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
PCA10_46200  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
PCA10_46210  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PCA10_47910  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PCA10_48600  [KO:K17103] [EC:2.7.8.8]
PCA10_51420  [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PCA10_51980  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
PCA10_52490  [KO:K25316]
PCA10_53260  [KO:K00274] [EC:1.4.3.4]
PCA10_53480  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
PCA10_54350  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PCA10_54360  gcvH; glycine cleavage system H protein [KO:K02437]
PCA10_54370  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pre00010  Glycolysis / Gluconeogenesis
pre00020  Citrate cycle (TCA cycle)
pre00230  Purine metabolism
pre00250  Alanine, aspartate and glutamate metabolism
pre00270  Cysteine and methionine metabolism
pre00290  Valine, leucine and isoleucine biosynthesis
pre00300  Lysine biosynthesis
pre00330  Arginine and proline metabolism
pre00460  Cyanoamino acid metabolism
pre00470  D-Amino acid metabolism
pre00564  Glycerophospholipid metabolism
pre00620  Pyruvate metabolism
pre00630  Glyoxylate and dicarboxylate metabolism
pre00640  Propanoate metabolism
pre00680  Methane metabolism
pre00860  Porphyrin metabolism
pre00920  Sulfur metabolism
KO pathway
ko00260   

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