KEGG PATHWAY: pss00260

PATHWAY: pss00260

Entry

pss00260                    Pathway

Name

Glycine, serine and threonine metabolism - Pelodiscus sinensis (Chinese soft-shelled turtle)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

pss00260

Glycine, serine and threonine metabolism

Module

pss_M00047

Creatine pathway [PATH:pss00260]

pss_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pss00260]

pss_M00555

Betaine biosynthesis, choline => betaine [PATH:pss00260]

pss_M00621

Glycine cleavage system [PATH:pss00260]

pss_M00974

Betaine metabolism, animals, betaine => glycine [PATH:pss00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Pelodiscus sinensis (Chinese soft-shelled turtle) [GN:pss]

Gene

102445079

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

106731855

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

102450557

glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]

102450327

glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]

102454533

GLYCTK; LOW QUALITY PROTEIN: glycerate kinase [KO:K11529] [EC:2.7.1.165]

102453933

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

102447629

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

102454056

PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]

102456091

PSPH; phosphoserine phosphatase isoform X2 [KO:K01079] [EC:3.1.3.3]

102462345

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

102451402

L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]

102460278

ALAS1; LOW QUALITY PROTEIN: 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

102448543

MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

102458176

amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

102463817

LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

102464074

membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]

102451010

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

102451894

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

102462504

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

102458200

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

102462192

DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

102449032

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

102462002

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

102458769

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

102447520

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

102458471

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

102445649

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

102445412

DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]

102455800

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

102460961

glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

102445047

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

102444730

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

102450482

CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]

102460488

uncharacterized protein LOC102460488 [KO:K01754] [EC:4.3.1.19]

102452378

SDSL; LOW QUALITY PROTEIN: serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

102454795

L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

102452370

SRR; LOW QUALITY PROTEIN: serine racemase [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721