Entry Name ECM-receptor interaction - Pan troglodytes (chimpanzee)
Description The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene 451860 COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719 ]
452659 COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237 ]
459986 COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237 ]
465804 COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237 ]
452661 COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237 ]
459988 COL4A3; collagen alpha-3(IV) chain isoform X4 [KO:K06237 ]
474056 COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238 ]
742913 COL6A6; collagen alpha-6(VI) chain isoform X2 [KO:K06238 ]
749971 LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238 ]
745218 COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131 ]
462810 COL9A1; collagen alpha-1(IX) chain isoform X4 [KO:K08131 ]
456791 COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131 ]
455302 LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637 ]
472122 LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637 ]
455339 LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240 ]
458387 LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240 ]
462946 LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241 ]
457571 LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246 ]
464805 LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247 ]
469068 COMP; cartilage oligomeric matrix protein precursor [KO:K04659 ]
461226 FRAS1; extracellular matrix organizing protein FRAS1 isoform X2 [KO:K23379 ]
467266 FREM2; FRAS1-related extracellular matrix protein 2 [KO:K23380 ]
464998 FREM1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380 ]
741526 DMP1; dentin matrix acidic phosphoprotein 1 isoform X1 [KO:K23328 ]
471250 MEPE; matrix extracellular phosphoglycoprotein isoform X1 [KO:K26442 ]
100613114 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255 ]
467765 SV2B; synaptic vesicle glycoprotein 2B isoform X1 [KO:K06258 ]
468166 GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261 ]
460569 CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266 ]
737973 HMMR; hyaluronan mediated motility receptor isoform X1 [KO:K06267 ]
Compound Reference Authors van der Flier A, Sonnenberg A.
Title Function and interactions of integrins.
Journal Reference Authors Reddy KV, Mangale SS.
Title Integrin receptors: the dynamic modulators of endometrial function.
Journal Reference Authors Milner R, Campbell IL.
Title The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal Reference Authors Cichy J, Pure E.
Title The liberation of CD44.
Journal Reference Authors Elenius K, Jalkanen M.
Title Function of the syndecans--a family of cell surface proteoglycans.
Journal J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference Authors Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
Title The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal Reference Authors Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
Title Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal Reference Authors Canobbio I, Balduini C, Torti M.
Title Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal Reference Authors Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
Title Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal Reference Authors Martin PT.
Title Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal Reference Authors Toole BP.
Title Hyaluronan: from extracellular glue to pericellular cue.
Journal Reference Authors Bosman FT, Stamenkovic I.
Title Functional structure and composition of the extracellular matrix.
Journal Reference Authors van der Ven AT, Vivante A, Hildebrandt F
Title Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal Related KO pathway LinkDB All DBs
