KEGG   PATHWAY: ptr04510
Entry
ptr04510                    Pathway                                
Name
Focal adhesion - Pan troglodytes (chimpanzee)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ptr04510  Focal adhesion
ptr04510

Other DBs
GO: 0005925
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
455117  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104001053  COL1A1; collagen alpha-1(I) chain [KO:K06236]
451860  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
452659  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
459986  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
465804  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
452661  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
459988  COL4A3; collagen alpha-3(IV) chain isoform X4 [KO:K06237]
465805  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
460045  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
474056  COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
450204  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
742913  COL6A6; collagen alpha-6(VI) chain isoform X2 [KO:K06238]
470923  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
749971  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
745218  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
462810  COL9A1; collagen alpha-1(IX) chain isoform X4 [KO:K08131]
456791  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
455302  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
472122  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
455339  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
458387  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
462946  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
463656  LAMB1; laminin subunit beta-1 [KO:K05636]
460365  LAMB2; laminin subunit beta-2 [KO:K06243]
469668  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
457570  LAMC1; laminin subunit gamma-1 [KO:K05635]
457571  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
464805  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
747194  CHAD; chondroadherin [KO:K06248]
463635  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
453319  THBS1; thrombospondin-1 [KO:K16857]
469068  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
457359  THBS3; thrombospondin-3 isoform X10 [KO:K04659]
463138  THBS2; thrombospondin-2 [KO:K04659]
450172  THBS4; thrombospondin-4 [KO:K04659]
459926  FN1; fibronectin isoform X14 [KO:K05717]
461366  SPP1; osteopontin isoform X1 [KO:K06250]
738261  VTN; vitronectin [KO:K06251]
742736  TNC; tenascin isoform X7 [KO:K06252]
469593  TNN; tenascin-N [KO:K06252]
469594  TNR; tenascin-R isoform X2 [KO:K06252]
462578  tenascin-X isoform X2 [KO:K06252]
451773  VWF; von Willebrand factor [KO:K03900]
471249  IBSP; bone sialoprotein 2 [KO:K06253]
461880  ITGA1; integrin alpha-1 [KO:K06480]
471550  ITGA2; integrin alpha-2 isoform X3 [KO:K06481]
454730  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
455111  ITGA3; integrin alpha-3 isoform X3 [KO:K06482]
470596  ITGA4; integrin alpha-4 isoform X4 [KO:K06483]
451958  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
459742  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
451967  ITGA7; integrin alpha-7 isoform X4 [KO:K06583]
450323  ITGA8; integrin alpha-8 isoform X3 [KO:K06584]
470789  ITGA9; integrin alpha-9 isoform X2 [KO:K06585]
457982  ITGA10; integrin alpha-10 [KO:K06586]
453537  ITGA11; integrin alpha-11 [KO:K06587]
459807  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
450396  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
468295  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
454887  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
460646  ITGB5; integrin beta-5 [KO:K06588]
459683  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
451934  ITGB7; integrin beta-7 [KO:K06590]
463282  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
453910  EMP2; epithelial membrane protein 2 isoform X1 [KO:K26256]
740202  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
458844  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
466765  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
736477  PDGFC; platelet-derived growth factor C isoform X3 [KO:K05450]
461435  EGF; pro-epidermal growth factor isoform X5 [KO:K04357]
741055  IGF1; insulin-like growth factor I isoform X6 [KO:K05459]
736875  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
741897  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
741830  PGF; placenta growth factor isoform X3 [KO:K16859]
471358  VEGFC; vascular endothelial growth factor C [KO:K05449]
465508  VEGFD; vascular endothelial growth factor D [KO:K05449]
461318  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
462188  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
453676  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
461315  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
463415  EGFR; epidermal growth factor receptor isoform X3 [KO:K04361] [EC:2.7.10.1]
452512  FLT1; vascular endothelial growth factor receptor 1 isoform X9 [KO:K05096] [EC:2.7.10.1]
462339  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
463671  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
454636  ERBB2; receptor tyrosine-protein kinase ErbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
741239  EMP1; epithelial membrane protein 1 [KO:K26255]
458229  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
456157  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
467419  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
461014  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
462144  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
455326  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
470307  ROCK2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
452243  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
750383  myosin light chain 5 isoform X1 [KO:K12753]
463920  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
458216  MYL9; myosin regulatory light polypeptide 9 isoform X2 [KO:K12755]
472470  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
455313  MYL12B; myosin regulatory light chain 12B [KO:K12757]
455314  MYL12A; myosin regulatory light chain 12A isoform X3 [KO:K12757]
471369  myosin regulatory light chain 12B [KO:K12757]
107968677  MYL11; myosin regulatory light chain 11 [KO:K12758]
462795  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
745709  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
743656  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
459118  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
452095  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
456295  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
742591  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
465143  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
471840  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101057233  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
455590  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
464513  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4 [KO:K00889] [EC:2.7.1.68]
457288  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
746570  ACTG1; actin, cytoplasmic 2 [KO:K05692]
450133  ACTB; actin, cytoplasmic 1 [KO:K05692]
453575  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X5 [KO:K04349]
457765  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
456010  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
452993  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
453494  TLN2; talin-2 isoform X1 [KO:K06271]
465082  TLN1; talin-1 [KO:K06271]
465940  FLNA; filamin-A isoform X1 [KO:K04437]
460476  FLNB; filamin-B isoform X4 [KO:K27392]
452303  PXN; paxillin isoform X14 [KO:K05760]
748941  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
463807  ZYX; zyxin isoform X4 [KO:K06273]
107969760  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
450531  VCL; vinculin isoform X1 [KO:K05700]
458899  PARVG; gamma-parvin isoform X1 [KO:K06275]
748437  PARVA; alpha-parvin [KO:K06275]
458898  PARVB; beta-parvin isoform X6 [KO:K06275]
467875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112205915  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
456035  AKT2; RAC-beta serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
740898  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100609583  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100616510  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
450183  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
454832  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
453993  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
456276  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
464422  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
460858  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
457922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
471079  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
456565  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
461836  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
466142  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
455647  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
473114  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
457076  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
741907  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
465884  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
742575  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
747131  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
451439  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
460965  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
450118  PAK3; serine/threonine-protein kinase PAK 3 isoform X2 [KO:K05733] [EC:2.7.11.1]
100609406  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
469876  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
453327  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
456609  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
454246  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
747142  CRK; adapter molecule crk isoform X1 [KO:K04438]
107970369  CRKL; crk-like protein [KO:K04438]
104001055  DOCK1; dedicator of cytokinesis protein 1 isoform X6 [KO:K13708]
464812  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X12 [KO:K06277]
469408  RAP1A; ras-related protein Rap-1A [KO:K04353]
452065  RAP1B; ras-related protein Rap-1b [KO:K07836]
450445  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
462336  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
461358  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
456893  JUN; transcription factor Jun [KO:K04448]
463781  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
463670  CAV1; caveolin-1 [KO:K06278]
736452  CAV2; caveolin-2 [KO:K12958]
738786  CAV3; caveolin-3 [KO:K12959]
462944  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
457351  SHC1; SHC-transforming protein 1 isoform X8 [KO:K06279]
749831  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
450176  SHC3; SHC-transforming protein 3 isoform X2 [KO:K17448]
453414  SHC4; SHC-transforming protein 4 isoform X2 [KO:K17449]
737245  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
459171  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
452897  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
466302  HRAS; GTPase HRas isoform X1 [KO:K02833]
460182  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
450188  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
454037  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
458680  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
473591  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
747442  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
747123  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
462689  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
451508  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X3 [KO:K16060]
451507  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
473765  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100615623  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
738409  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
ptr04010  MAPK signaling pathway
ptr04060  Cytokine-cytokine receptor interaction
ptr04070  Phosphatidylinositol signaling system
ptr04110  Cell cycle
ptr04151  PI3K-Akt signaling pathway
ptr04310  Wnt signaling pathway
ptr04512  ECM-receptor interaction
ptr04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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