KEGG   PATHWAY: pza00260
Entry
pza00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas ogarae SWRI108
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pza00260  Glycine, serine and threonine metabolism
pza00260

Module
pza_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pza00260]
pza_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pza00260]
pza_M00555  Betaine biosynthesis, choline => betaine [PATH:pza00260]
pza_M00621  Glycine cleavage system [PATH:pza00260]
pza_M00919  Ectoine degradation, ectoine => aspartate [PATH:pza00260]
pza_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pza00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas ogarae SWRI108 [GN:pza]
Gene
HU749_000720  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HU749_000750  [KO:K00133] [EC:1.2.1.11]
HU749_001045  [KO:K02204] [EC:2.7.1.39]
HU749_001615  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HU749_001620  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HU749_002190  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HU749_002220  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HU749_002745  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HU749_003675  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HU749_003945  [KO:K16066] [EC:1.1.1.381 1.1.1.-]
HU749_005645  [KO:K00018] [EC:1.1.1.29]
HU749_006220  [KO:K00003] [EC:1.1.1.3]
HU749_006225  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HU749_009345  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HU749_009985  [KO:K00836] [EC:2.6.1.76]
HU749_012755  [KO:K00305] [EC:1.5.3.24 1.5.3.1]
HU749_012760  [KO:K00302] [EC:1.5.3.24 1.5.3.1]
HU749_012765  [KO:K00304] [EC:1.5.3.24 1.5.3.1]
HU749_012770  [KO:K00303] [EC:1.5.3.24 1.5.3.1]
HU749_012825  [KO:K00605] [EC:2.1.2.10]
HU749_012840  [KO:K00605] [EC:2.1.2.10]
HU749_013530  [KO:K00836] [EC:2.6.1.76]
HU749_013810  [KO:K01754] [EC:4.3.1.19]
HU749_014625  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HU749_014945  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HU749_014955  [KO:K00003] [EC:1.1.1.3]
HU749_015935  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
HU749_018165  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HU749_018245  [KO:K00865] [EC:2.7.1.165]
HU749_018575  [KO:K12972] [EC:1.1.1.79 1.1.1.81]
HU749_019205  [KO:K00479] [EC:1.14.13.251]
HU749_019325  [KO:K00479] [EC:1.14.13.251]
HU749_019330  [KO:K21832] [EC:1.14.13.251]
HU749_020235  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HU749_020340  [KO:K00600] [EC:2.1.2.1]
HU749_020845  thrH; bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH [KO:K02203] [EC:3.1.3.3 2.7.1.39]
HU749_021815  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HU749_021915  [KO:K11529] [EC:2.7.1.165]
HU749_022770  [KO:K00928] [EC:2.7.2.4]
HU749_022780  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HU749_023325  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HU749_023330  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HU749_023335  [KO:K01752] [EC:4.3.1.17]
HU749_023340  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HU749_023720  [KO:K00130] [EC:1.2.1.8]
HU749_024475  [KO:K15785] [EC:2.6.1.76]
HU749_024480  [KO:K15786] [EC:1.2.1.-]
HU749_024490  doeB; N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
HU749_024495  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
HU749_024505  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
HU749_024615  [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
HU749_024685  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HU749_024690  [KO:K00600] [EC:2.1.2.1]
HU749_025235  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HU749_025730  [KO:K00600] [EC:2.1.2.1]
HU749_026390  [KO:K00003] [EC:1.1.1.3]
HU749_026400  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HU749_027570  [KO:K00305] [EC:1.5.3.24 1.5.3.1]
HU749_027575  [KO:K00302] [EC:1.5.3.24 1.5.3.1]
HU749_027580  [KO:K00304] [EC:1.5.3.24 1.5.3.1]
HU749_027585  [KO:K00303] [EC:1.5.3.24 1.5.3.1]
HU749_027590  [KO:K00600] [EC:2.1.2.1]
HU749_027600  [KO:K01620] [EC:4.1.2.48]
HU749_027605  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
HU749_027610  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
HU749_027630  [KO:K25961]
HU749_027635  [KO:K25960]
HU749_027640  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
HU749_027645  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
HU749_027715  [KO:K01752] [EC:4.3.1.17]
HU749_027740  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HU749_027745  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
HU749_027970  [KO:K00274] [EC:1.4.3.4]
HU749_028705  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HU749_028710  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pza00010  Glycolysis / Gluconeogenesis
pza00020  Citrate cycle (TCA cycle)
pza00230  Purine metabolism
pza00250  Alanine, aspartate and glutamate metabolism
pza00270  Cysteine and methionine metabolism
pza00290  Valine, leucine and isoleucine biosynthesis
pza00300  Lysine biosynthesis
pza00330  Arginine and proline metabolism
pza00460  Cyanoamino acid metabolism
pza00470  D-Amino acid metabolism
pza00564  Glycerophospholipid metabolism
pza00620  Pyruvate metabolism
pza00630  Glyoxylate and dicarboxylate metabolism
pza00640  Propanoate metabolism
pza00680  Methane metabolism
pza00860  Porphyrin metabolism
pza00920  Sulfur metabolism
KO pathway
ko00260   

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