KEGG   PATHWAY: rn00053
Entry
rn00053                     Pathway                                
Name
Ascorbate and aldarate metabolism
Class
Metabolism; Carbohydrate metabolism
Pathway map
rn00053  Ascorbate and aldarate metabolism
rn00053

Module
M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:rn00053]
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate [PATH:rn00053]
M00550  Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:rn00053]
M00994  UDP-GlcA biosynthesis, myo-inositol => GlcA => UDP-GlcA [PATH:rn00053]
M00999  UDP-GlcA/GalA biosynthesis, UDP-Glc => UDP-GlcA => UDP-GalA [PATH:rn00053]
Other DBs
GO: 0019852 0019577 0019572
Reaction
R00068  L-ascorbate:oxygen oxidoreductase
R00095  NADH:monodehydroascorbate oxidoreductase
R00264  2,5-dioxopentanoate:NADP+ 5-oxidoreductase
R00286  UDP-glucose:NAD+ 6-oxidoreductase
R00640  L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase
R00643  L-galactono-1,4-lactone:oxygen 3-oxidoreductase
R00645  ascorbate:acceptor oxidoreductase
R00646  
R00647  
R00889  GDP-mannose 3,5-epimerase
R01108  glutathione:dehydroascorbate oxidoreductase
R01184  myo-inositol:oxygen oxidoreductase
R01381  UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
R01383  UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
R01385  UDP-glucuronate 4-epimerase
R01476  ATP:D-glucuronate 1-phosphotransferase
R01478  beta-D-glucuronoside glucuronosohydrolase
R01481  L-gulonate:NADP+ 6-oxidoreductase
R01483  D-glucuronolactone lactonohydrolase
R01574  D-arabinose:NAD+ 1-oxidoreductase
R01575  D-arabinose:NADP+ 1-oxidoreductase
R01757  L-arabinose:NAD+ 1-oxidoreductase
R01784  2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)
R02278  2-dehydro-3-deoxy-L-arabinonate hydro-lyase
R02279  5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)
R02522  L-arabinonate hydro-lyase
R02526  L-arabinono-1,4-lactone lactonohydrolase
R02634  UTP:1-phospho-alpha-D-galacturonate uridylyltransferase; UDP-D-galacturonate pyrophospholylase
R02637  3-dehydro-L-gulonate:NAD+ 2-oxidoreductase
R02639  3-dehydro-L-gulonate:NADP+ 2-oxidoreductase
R02714  D-arabinono-1,4-lactone lactonohydrolase
R02715  D-arabinono-1,4-lactone:oxygen oxidoreductase
R02752  D-glucarate hydro-lyase
R02754  5-dehydro-4-deoxy-D-glucarate tartronate-semialdehyde-lyase
R02933  L-gulono-1,4-lactone lactonohydrolase
R02957  D-glucuronolactone:NAD+ oxidoreductase
R03032  D-arabinonate hydro-lyase
R03183  L-gulono-1,4-lactone:NADP+ 1-oxidoreductase
R03184  L-gulono-1,4-lactone:oxygen 2-oxidoreductase
R03185  monodehydroascorbate:acceptor oxidoreductase
R03186  
R03244  L-ribulose-5-phosphate 3-epimerase; L-xylulose 5-phosphate 3-epimerase
R03277  
R03733  L-threonate:NAD+ 3-oxidoreductase
R04515  
R04784  
R04785  L-dehydroascorbate lactonohydrolase
R05608  galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)
R05850  L-ribulose-5-phosphate 4-epimerase
R07125  3-dehydro-L-gulonate-6-phosphate carboxy-lyase
R07127  ATP:3-dehydro-L-gulonate 6-phosphotransferase
R07671  
R07672  GDP-mannose 5-epimerase
R07673  
R07674  beta-L-galactose-1-phosphate phosphohydrolase
R07675  L-galactose:NAD+ 1-oxidoreductase
R07676  L-galactonate:NADP+ oxidoreductase
R07677  
R07678  GDP-beta-L-galactose:hexose 1-phosphate guanylyltransferase
R07679  
R07680  
R08056  D-glucarate hydro-lyase
R08615  UDP-glucuronate glucuronohydrolase
R09186  2-dehydro-3-deoxy-D-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)
R09540  
R10787  L-arabinose:NADP+ 1-oxidoreductase
R10841  D-galacturonate:NAD+ 1-oxidoreductase
R10846  D-galactarolactone 4,5-acylmutase
R10847  D-galactaro-1,4-lactone lyase (ring-opening)
R12146  L-galactonate:NAD+ 5-oxidoreductase
R12155  L-galactono-1,5-lactone lactonohydrolase
R12156  L-galactose:NADP+ oxidoreductase
R12661  1-phospho-alpha-D-galacturonate phosphohydrolase
R12761  L-lyxonate hydro-lyase
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
rn00020  Citrate cycle (TCA cycle)
rn00040  Pentose and glucuronate interconversions
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   

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