KEGG   PATHWAY: rno00630
Entry
rno00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Rattus norvegicus (rat)
Class
Metabolism; Carbohydrate metabolism
Pathway map
rno00630  Glyoxylate and dicarboxylate metabolism
rno00630

Module
rno_M00621  Glycine cleavage system [PATH:rno00630]
rno_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:rno00630]
Other DBs
GO: 0046487 0043648
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
296259  Acss1; acetyl-coenzyme A synthetase 2-like, mitochondrial [KO:K01895] [EC:6.2.1.1]
311569  Acss2; acetyl-coenzyme A synthetase, cytoplasmic [KO:K01895] [EC:6.2.1.1]
24551  Mdh1; malate dehydrogenase, cytoplasmic isoform Mdh1 [KO:K00025] [EC:1.1.1.37]
81829  Mdh2; malate dehydrogenase, mitochondrial precursor [KO:K00026] [EC:1.1.1.37]
170587  Cs; citrate synthase, mitochondrial precursor [KO:K01647] [EC:2.3.3.1]
120093130  Cs-ps1; LOW QUALITY PROTEIN: citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
79250  Aco2; aconitate hydratase, mitochondrial precursor [KO:K01681] [EC:4.2.1.3]
50655  Aco1; cytoplasmic aconitate hydratase [KO:K01681] [EC:4.2.1.3]
25014  Acat1; acetyl-CoA acetyltransferase, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
308100  Acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
365096  Acat2l1; acetyl-CoA acetyltransferase, cytosolic-like isoform X1 [KO:K00626] [EC:2.3.1.9]
293829  Mcee; methylmalonyl-CoA epimerase, mitochondrial [KO:K05606] [EC:5.1.99.1]
687008  Pcca; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
24624  Pccb; propionyl-CoA carboxylase beta chain, mitochondrial precursor [KO:K01966] [EC:6.4.1.3 2.1.3.15]
688517  Mmut; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
84029  Hao2; 2-Hydroxyacid oxidase 2 [KO:K11517] [EC:1.1.3.15]
311446  Hao1; 2-Hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
24248  Cat; catalase [KO:K03781] [EC:1.11.1.6]
680021  Grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
287115  Pgp; glycerol-3-phosphate phosphatase [KO:K19269] [EC:3.1.3.18 3.1.3.48]
24792  Agxt; alanine--glyoxylate aminotransferase isoform 1 precursor [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
24957  Glul; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
299857  Shmt2; serine hydroxymethyltransferase, mitochondrial isoform 1 [KO:K00600] [EC:2.1.2.1]
287379  Shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
309312  Gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
306586  Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
298942  Dld; dihydrolipoyl dehydrogenase, mitochondrial precursor [KO:K00382] [EC:1.8.1.4]
171133  Gcsh; glycine cleavage system H protein, mitochondrial precursor [KO:K02437]
292151  Gcshl1; glycine cleavage system H protein, mitochondrial-like [KO:K02437]
500536  Hyi; putative hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
684314  Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
293949  Hoga1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial [KO:K18123] [EC:4.1.3.16]
688283  Afmid; kynurenine formamidase [KO:K01432] [EC:3.5.1.9]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
rno00010  Glycolysis / Gluconeogenesis
rno00020  Citrate cycle (TCA cycle)
rno00030  Pentose phosphate pathway
rno00053  Ascorbate and aldarate metabolism
rno00071  Fatty acid degradation
rno00230  Purine metabolism
rno00250  Alanine, aspartate and glutamate metabolism
rno00260  Glycine, serine and threonine metabolism
rno00620  Pyruvate metabolism
rno00750  Vitamin B6 metabolism
rno00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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