KEGG   PATHWAY: rno00230
Entry
rno00230                    Pathway                                
Name
Purine metabolism - Rattus norvegicus (rat)
Class
Metabolism; Nucleotide metabolism
Pathway map
rno00230  Purine metabolism
rno00230

Module
rno_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:rno00230]
rno_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:rno00230]
rno_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:rno00230]
rno_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:rno00230]
rno_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:rno00230]
rno_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:rno00230]
rno_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:rno00230]
Other DBs
GO: 0006163 0042278
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100359539  Rrm2l1; ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
100360582  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
100363253  Nt5c2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
102238592  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
113911  Gucy2e; guanylate cyclase 2D precursor [KO:K12321] [EC:4.6.1.2]
114248  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
114768  Uox; uricase [KO:K00365] [EC:1.7.3.3]
116556  Gucy2f; retinal guanylyl cyclase 2 precursor [KO:K12322] [EC:4.6.1.2]
116564  Npr2; atrial natriuretic peptide receptor 2 precursor [KO:K12324] [EC:4.6.1.2]
117533  Gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
117544  Ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
140928  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 4 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
140929  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
140946  Paics; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
171115  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
171566  Nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
191569  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
191575  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
192357  Gmpr2; GMP reductase 2 isoform 1 [KO:K00364] [EC:1.7.1.7]
24165  Ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
24183  Ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
24184  Ak2; adenylate kinase 2, mitochondrial isoform b [KO:K00939] [EC:2.7.4.3]
24465  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
245708  Gucy2g; guanylate cyclase 2G [KO:K22600] [EC:4.6.1.2]
24603  Npr1; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
24626  Pde4b; 3',5'-cyclic-AMP phosphodiesterase 4B isoform 2 [KO:K13293] [EC:3.1.4.53]
24627  Pde4d; 3',5'-cyclic-AMP phosphodiesterase 4D isoform 1 [KO:K13293] [EC:3.1.4.53]
246272  Cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
24645  Pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
246758  Allc; probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
24689  Prps2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
25028  Ampd1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
25095  Ampd3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
25202  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
25206  Gucy1b2; guanylate cyclase soluble subunit beta-2 isoform 2 [KO:K12319] [EC:4.6.1.2]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
25368  Adk; adenosine kinase [KO:K00856] [EC:2.7.1.20]
25638  Pde4a; 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1 [KO:K13293] [EC:3.1.4.53]
25711  Gucy2c; guanylyl cyclase C precursor [KO:K12320] [EC:4.6.1.2]
26956  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
287368  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
287406  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
287420  Pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
288259  Gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
289276  Adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
289632  Pgm2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
289878  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
290029  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
290646  Pde4c; 3',5'-cyclic-AMP phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
292072  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
29223  Ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
293613  Urah; 5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
294103  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
294521  Ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
295088  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
29516  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
295443  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
29562  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
29691  Pde1b; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
297389  Dguok; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
297998  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
298881  Nt5c1b; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
298954  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
299976  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
301005  Impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
301261  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 precursor [KO:K18424] [EC:3.6.1.29]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
303179  Guk1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
305149  Nudt9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
307401  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
308758  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
308776  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
309962  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
310664  Prune1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
311422  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
311833  Ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
313574  Nt5c1a; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
313790  Lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
314140  Prps1l3; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
314312  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 precursor [KO:K01511] [EC:3.6.1.6]
314416  Ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
315150  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
316077  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
361063  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform 1 [KO:K12305] [EC:3.6.1.6]
361274  Nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
361443  Ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
361462  Hddc2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
361752  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
362015  Ampd2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
362329  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform 2 [KO:K00088] [EC:1.1.1.205]
362720  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
363129  Nudt16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
363272  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
365985  Ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
497757  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
497811  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
500039  RGD1562178; adenylate kinase 2, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
50678  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
54410  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
58813  Nt5e; 5'-nucleotidase precursor [KO:K19970] [EC:3.1.3.5]
58964  Nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
59320  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
60398  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
613267  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
63885  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
64467  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 precursor [KO:K01509] [EC:3.6.1.-]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
64519  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
66012  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
684055  Urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
684425  Adss1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
685579  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
685679  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
688297  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
688828  Nudt16l2; uncharacterized protein LOC688828 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
79127  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
79222  Gucy2d; retinal guanylyl cyclase 1 precursor [KO:K12321] [EC:4.6.1.2]
81529  Pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
81643  Atic; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
81742  Pde1c; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
81743  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor [KO:K18283] [EC:3.1.4.17]
81744  Pde7a; high affinity 3',5'-cyclic-AMP phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
83585  Gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
83782  Nme2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
85260  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
85269  Nme3; nucleoside diphosphate kinase 3 precursor [KO:K00940] [EC:2.7.4.6]
85496  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
rno00030  Pentose phosphate pathway
rno00220  Arginine biosynthesis
rno00250  Alanine, aspartate and glutamate metabolism
rno00260  Glycine, serine and threonine metabolism
rno00340  Histidine metabolism
rno00630  Glyoxylate and dicarboxylate metabolism
rno00730  Thiamine metabolism
rno00740  Riboflavin metabolism
rno00790  Folate biosynthesis
KO pathway
ko00230   

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