KEGG   PATHWAY: rno00620
Entry
rno00620                    Pathway                                
Name
Pyruvate metabolism - Rattus norvegicus (rat)
Class
Metabolism; Carbohydrate metabolism
Pathway map
rno00620  Pyruvate metabolism
rno00620

Module
rno_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:rno00620]
Other DBs
GO: 0006090
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100145871  Adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100362738  Pkml1; pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
116719  Acacb; acetyl-CoA carboxylase 2 precursor [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
117098  Pdha2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor [KO:K00161] [EC:1.2.4.1]
170570  Acot12; acetyl-coenzyme A thioesterase [KO:K01067] [EC:3.1.2.1]
171178  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
24172  Adh1c; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
24368  Fh; fumarate hydratase, mitochondrial precursor [KO:K01679] [EC:4.2.1.2]
24439  Hagh; hydroxyacylglutathione hydrolase, mitochondrial precursor [KO:K01069] [EC:3.1.2.6]
24533  Ldha; L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
24534  Ldhb; L-lactate dehydrogenase B chain isoform Ldhb [KO:K00016] [EC:1.1.1.27]
24551  Mdh1; malate dehydrogenase, cytoplasmic isoform Mdh1 [KO:K00025] [EC:1.1.1.37]
24552  Me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
24651  Pklr; pyruvate kinase PKLR [KO:K12406] [EC:2.7.1.40]
25014  Acat1; acetyl-CoA acetyltransferase, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
25104  Pc; pyruvate carboxylase, mitochondrial precursor [KO:K01958] [EC:6.4.1.1]
25630  Pkm; pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
289950  Pdhb; pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor [KO:K00162] [EC:1.2.4.1]
291450  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
294320  Glo1; lactoylglutathione lyase [KO:K01759] [EC:4.4.1.5]
29539  Aldh2; aldehyde dehydrogenase, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
29554  Pdha1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor [KO:K00161] [EC:1.2.4.1]
296259  Acss1; acetyl-coenzyme A synthetase 2-like, mitochondrial [KO:K01895] [EC:6.2.1.1]
29634  Ldhc; L-lactate dehydrogenase C chain [KO:K00016] [EC:1.1.1.27]
29646  Adh4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
298079  Aldh1b1; aldehyde dehydrogenase X, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
298942  Dld; dihydrolipoyl dehydrogenase, mitochondrial precursor [KO:K00382] [EC:1.8.1.4]
299203  Acyp1; acylphosphatase-1 [KO:K01512] [EC:3.6.1.7]
307270  Me2; NAD-dependent malic enzyme, mitochondrial [KO:K00027] [EC:1.1.1.38]
307858  Ldhd; probable D-lactate dehydrogenase, mitochondrial [KO:K00102] [EC:1.1.2.4]
308100  Acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
310903  Adh6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
311569  Acss2; acetyl-coenzyme A synthetase, cytoplasmic [KO:K01895] [EC:6.2.1.1]
361042  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
361602  Me3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
362282  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
364224  Acyp2; acylphosphatase-2 [KO:K01512] [EC:3.6.1.7]
365096  Acat2l1; acetyl-CoA acetyltransferase, cytosolic-like isoform X1 [KO:K00626] [EC:2.3.1.9]
369018  Ldhal6b; L-lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
500965  Ldhal1; L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
60581  Acaca; acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
64040  Aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
65183  Aldh3a2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
680021  Grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
78959  Akr1a1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
81654  Dlat; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
81829  Mdh2; malate dehydrogenase, mitochondrial precursor [KO:K00026] [EC:1.1.1.37]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00033  Acetate
C00036  Oxaloacetate
C00042  Succinate
C00058  Formate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00122  Fumarate
C00149  (S)-Malate
C00186  (S)-Lactate
C00227  Acetyl phosphate
C00256  (R)-Lactate
C00332  Acetoacetyl-CoA
C00424  (S)-Lactaldehyde
C00469  Ethanol
C00546  Methylglyoxal
C00937  (R)-Lactaldehyde
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C02488  (R)-2-Ethylmalate
C02504  alpha-Isopropylmalate
C03248  Acetylenedicarboxylate
C03451  (R)-S-Lactoylglutathione
C03981  2-Hydroxyethylenedicarboxylate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05993  Acetyl adenylate
C05994  2-Propylmalate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Related
pathway
rno00010  Glycolysis / Gluconeogenesis
rno00020  Citrate cycle (TCA cycle)
rno00061  Fatty acid biosynthesis
rno00250  Alanine, aspartate and glutamate metabolism
rno00260  Glycine, serine and threonine metabolism
rno00290  Valine, leucine and isoleucine biosynthesis
rno00630  Glyoxylate and dicarboxylate metabolism
rno00640  Propanoate metabolism
rno00650  Butanoate metabolism
rno00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00620   

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