KEGG   PATHWAY: rno00010
Entry
rno00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Rattus norvegicus (rat)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
rno00010  Glycolysis / Gluconeogenesis
rno00010

Module
rno_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:rno00010]
rno_M00002  Glycolysis, core module involving three-carbon compounds [PATH:rno00010]
rno_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:rno00010]
rno_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:rno00010]
Other DBs
GO: 0006096 0006094
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
25058  Hk1; hexokinase-1 [KO:K00844] [EC:2.7.1.1]
25059  Hk2; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
25060  Hk3; hexokinase-3 [KO:K00844] [EC:2.7.1.1]
100364027  Hkdc1; hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
24385  Gck; hexokinase-4 isoform 2 [KO:K12407] [EC:2.7.1.2]
292804  Gpi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
65152  Pfkm; ATP-dependent 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
25741  Pfkl; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
60416  Pfkp; ATP-dependent 6-phosphofructokinase, platelet type [KO:K00850] [EC:2.7.1.11]
24362  Fbp1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
114508  Fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
24189  Aldoa; fructose-bisphosphate aldolase A [KO:K01623] [EC:4.1.2.13]
24191  Aldoc; fructose-bisphosphate aldolase C [KO:K01623] [EC:4.1.2.13]
24190  Aldob; fructose-bisphosphate aldolase B [KO:K01623] [EC:4.1.2.13]
299052  Aldoart2; fructose-bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
24849  Tpi1; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
500959  triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
24383  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
303448  uncharacterized protein LOC303448 [KO:K00134] [EC:1.2.1.12]
290604  RGD1564958; glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
66020  Gapdhs; glyceraldehyde-3-phosphate dehydrogenase, testis-specific [KO:K10705] [EC:1.2.1.12]
24644  Pgk1; phosphoglycerate kinase 1 [KO:K00927] [EC:2.7.2.3]
316265  Pgk2; phosphoglycerate kinase 2 [KO:K00927] [EC:2.7.2.3]
24642  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
24959  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
24333  Eno1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
25438  Eno3; beta-enolase [KO:K01689] [EC:4.2.1.11]
24334  Eno2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
292138  Eno4; enolase 4 [KO:K01689] [EC:4.2.1.11]
25630  Pkm; pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
100364062  pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
24651  Pklr; pyruvate kinase PKLR [KO:K12406] [EC:2.7.1.40]
117098  Pdha2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor [KO:K00161] [EC:1.2.4.1]
29554  Pdha1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor [KO:K00161] [EC:1.2.4.1]
289950  Pdhb; pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor [KO:K00162] [EC:1.2.4.1]
81654  Dlat; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
298942  Dld; dihydrolipoyl dehydrogenase, mitochondrial precursor [KO:K00382] [EC:1.8.1.4]
24533  Ldha; L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
24534  Ldhb; L-lactate dehydrogenase B chain isoform Ldhb [KO:K00016] [EC:1.1.1.27]
29634  Ldhc; L-lactate dehydrogenase C chain [KO:K00016] [EC:1.1.1.27]
369018  Ldhal6b; L-lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
24172  Adh1; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
171178  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
29646  Adh4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
100145871  Adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
310903  Adh6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
78959  Akr1a1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
29539  Aldh2; aldehyde dehydrogenase, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
65183  Aldh3a2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
298079  Aldh1b1; aldehyde dehydrogenase X, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
291450  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
64040  Aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
25375  Aldh3a1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
309147  Aldh3b1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
688778  aldehyde dehydrogenase family 3 member B3 isoform X1 [KO:K00129] [EC:1.2.1.5]
688800  Aldh3b2; aldehyde dehydrogenase family 3 member B2 [KO:K00129] [EC:1.2.1.5]
296259  Acss1; acetyl-coenzyme A synthetase 2-like, mitochondrial [KO:K01895] [EC:6.2.1.1]
311569  Acss2; acetyl-coenzyme A synthetase, cytoplasmic [KO:K01895] [EC:6.2.1.1]
313843  Galm; galactose mutarotase [KO:K01785] [EC:5.1.3.3]
24645  Pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
25634  G6pc1; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
681817  G6pc2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
303565  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
315722  Adpgk; ADP-dependent glucokinase precursor [KO:K08074] [EC:2.7.1.147]
296973  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
29688  Minpp1; multiple inositol polyphosphate phosphatase 1 precursor [KO:K03103] [EC:3.1.3.62 3.1.3.80]
362282  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
361042  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
rno00020  Citrate cycle (TCA cycle)
rno00030  Pentose phosphate pathway
rno00500  Starch and sucrose metabolism
rno00620  Pyruvate metabolism
rno00640  Propanoate metabolism
KO pathway
ko00010   
LinkDB

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