Entry Name ABC transporters - Rattus norvegicus (rat)
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 114628 Abcg5; ATP-binding cassette sub-family G member 5 [KO:K05683 ]
116721 Abcc5; ATP-binding cassette sub-family C member 5 [KO:K05668 ]
140668 Abcc3; ATP-binding cassette sub-family C member 3 [KO:K05667 ]
140669 Abcb6; ATP-binding cassette sub-family B member 6 [KO:K05661 ]
155192 Abcg8; ATP-binding cassette sub-family G member 8 [KO:K05684 ]
170924 Abcc4; ATP-binding cassette subfamily C member 4 [KO:K05673 ]
25303 Abcc2; ATP-binding cassette sub-family C member 2 [KO:K05666 ]
25559 Abcc8; ATP-binding cassette sub-family C member 8 isoform 1 [KO:K05032 ]
25560 Abcc9; ATP-binding cassette sub-family C member 9 [KO:K05033 ]
287112 Abca17; ATP-binding cassette sub-family A member 17 [KO:K05643 ]
287788 Abca9; ATP-binding cassette sub-family A member 9 isoform X1 [KO:K05651 ]
289453 Abcg3l1; ATP-binding cassette, subfamily G (WHITE), member 3-like 1 [KO:K05682 ]
289797 Abca13; ATP-binding cassette sub-family A member 13 [KO:K05647 ]
291923 Abcc12; ATP-binding cassette sub-family C member 12 [KO:K05672 ]
293442 Abca15; ATP-binding cassette, sub-family A (ABC1), member 15 [KO:K05643 ]
293444 Abca16; phospholipid-transporting ATPase ABCA3-like isoform X1 [KO:K05643 ]
299609 Abca7; ATP-binding cassette sub-family A member 7 [KO:K05645 ]
300664 Abcg4; ATP-binding cassette subfamily G member 4 [KO:K05680 ]
301482 Abca12; glucosylceramide transporter ABCA12 isoform X1 [KO:K05646 ]
302395 Abcb7; iron-sulfur clusters transporter ABCB7, mitochondrial [KO:K05662 ]
302973 Abca3; phospholipid-transporting ATPase ABCA3 [KO:K05643 ]
303637 Abca8; ABC-type organic anion transporter ABCA8 isoform X1 [KO:K05650 ]
303638 Abca8a; ATP-binding cassette sub-family A member 8-A [KO:K05650 ]
303639 Abca6; ATP-binding cassette sub-family A member 6 isoform X2 [KO:K05649 ]
305142 Abcg3l3; ATP-binding cassette, sub-family G (WHITE), member 3 family member [KO:K05682 ]
310836 Abca4; retinal-specific phospholipid-transporting ATPase ABCA4 [KO:K05644 ]
312382 Abcg2; broad substrate specificity ATP-binding cassette transporter ABCG2 [KO:K05681 ]
313210 Abca1; phospholipid-transporting ATPase ABCA1 [KO:K05641 ]
314537 Abcb5; ATP-binding cassette sub-family B member 5 [KO:K05660 ]
316231 Abcc10; ATP-binding cassette sub-family C member 10 [KO:K05674 ]
361439 Abcb10; ATP-binding cassette sub-family B member 10, mitochondrial [KO:K05657 ]
362302 Abcb8; mitochondrial potassium channel ATP-binding subunit precursor [KO:K05655 ]
365362 Abca14; phospholipid-transporting ATPase ABCA3-like isoform X1 [KO:K05643 ]
498327 Abcg3; ATP-binding cassette, subfamily G (WHITE), member 3 [KO:K05682 ]
63886 Abcb9; ABC-type oligopeptide transporter ABCB9 [KO:K05656 ]
79248 Abca2; ATP-binding cassette sub-family A member 2 [KO:K05642 ]
81642 Abcc6; ATP-binding cassette sub-family C member 6 [KO:K05669 ]
85264 Abcg1; ATP-binding cassette sub-family G member 1 [KO:K05679 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
