KEGG   PATHWAY: roa00230
Entry
roa00230                    Pathway                                
Name
Purine metabolism - Rhodococcus opacus PD630
Class
Metabolism; Nucleotide metabolism
Pathway map
roa00230  Purine metabolism
roa00230

Module
roa_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:roa00230]
roa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:roa00230]
roa_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:roa00230]
roa_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:roa00230]
roa_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:roa00230]
roa_M00546  Purine degradation, xanthine => urea [PATH:roa00230]
roa_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:roa00230]
roa_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:roa00230]
Other DBs
GO: 0006163 0042278
Organism
Rhodococcus opacus PD630 [GN:roa]
Gene
Pd630_LPD03080  Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
Pd630_LPD02340  Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
Pd630_LPD01352  Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
Pd630_LPD01286  Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
Pd630_LPD02177  Trifunctional purine biosynthetic protein adenosine-3 [KO:K11175] [EC:2.1.2.2]
Pd630_LPD06427  Phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
Pd630_LPD01346  Phosphoribosylformylglycinamidine synthase 2 [KO:K23269] [EC:6.3.5.3]
Pd630_LPD01338  UPF0062 protein [KO:K23264] [EC:6.3.5.3]
Pd630_LPD01339  Phosphoribosylformylglycinamidine synthase 1 [KO:K23265] [EC:6.3.5.3 3.5.1.2]
Pd630_LPD01353  Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
Pd630_LPD02965  N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
Pd630_LPD02966  N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
Pd630_LPD01328  Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
Pd630_LPD01296  Adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
Pd630_LPD02178  Bifunctional purine biosynthesis protein purH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
Pd630_LPD03525  Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
Pd630_LPD00525  Endonuclease YhcR [KO:K01081] [EC:3.1.3.5]
Pd630_LPD06415  Protein nagD [KO:K02566] [EC:3.1.3.5]
Pd630_LPD02913  Purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
Pd630_LPD05179  UPF0124 protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
Pd630_LPD03983  Uridine nucleosidase 1 [KO:K01239] [EC:3.2.2.1]
Pd630_LPD00855  Hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Pd630_LPD02849  Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
Pd630_LPD02850  putative oxidoreductase [KO:K00088] [EC:1.1.1.205]
Pd630_LPD05425  Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
Pd630_LPD05555  Non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
Pd630_LPD04141  Putative xanthine dehydrogenase YagR molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
Pd630_LPD07365  Putative xanthine dehydrogenase YagR molybdenum-binding subunit [KO:K11177] [EC:1.17.1.4]
Pd630_LPD04140  Putative xanthine dehydrogenase YagS FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
Pd630_LPD07364  Putative xanthine dehydrogenase YagS FAD-binding subunit [KO:K11178] [EC:1.17.1.4]
Pd630_LPD04139  Putative xanthine dehydrogenase yagT iron-sulfur-binding subunit [KO:K13483]
Pd630_LPD07363  Putative xanthine dehydrogenase yagT iron-sulfur-binding subunit [KO:K13483]
Pd630_LPD02852  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
Pd630_LPD03992  putative oxidoreductase [KO:K26110] [EC:1.7.1.7]
Pd630_LPD00160  Guanine deaminase [KO:K01487] [EC:3.5.4.3]
Pd630_LPD03899  Guanylate kinase [KO:K00942] [EC:2.7.4.8]
Pd630_LPD03107  Ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
Pd630_LPD03108  Ribonucleoside-diphosphate reductase subunit beta nrdF2 [KO:K00526] [EC:1.17.4.1]
Pd630_LPD02868  R2-like ligand binding oxidase [KO:K00526] [EC:1.17.4.1]
Pd630_LPD05317  Deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
Pd630_LPD03526  putative GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
Pd630_LPD02397  Bifunctional 3-dehydroquinate synthase/phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Pd630_LPD06242  Uncharacterized protein [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Pd630_LPD01601  Adenylate cyclase [KO:K01768] [EC:4.6.1.1]
Pd630_LPD01689  Uncharacterized protein [KO:K01768] [EC:4.6.1.1]
Pd630_LPD06112  pH-sensitive adenylate cyclase [KO:K01768] [EC:4.6.1.1]
Pd630_LPD06366  pH-sensitive adenylate cyclase [KO:K01768] [EC:4.6.1.1]
Pd630_LPD02137  Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
Pd630_LPD05236  Adenosine kinase [KO:K00856] [EC:2.7.1.20]
Pd630_LPD02902  Adenosine deaminase [KO:K01488] [EC:3.5.4.4]
Pd630_LPD02666  Adenine deaminase [KO:K21053] [EC:3.5.4.2]
Pd630_LPD02796  Adenylate kinase [KO:K00939] [EC:2.7.4.3]
Pd630_LPD03661  Adenylate kinase [KO:K00939] [EC:2.7.4.3]
Pd630_LPD02377  Nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
Pd630_LPD04753  Uncharacterized protein [KO:K03651] [EC:3.1.4.53]
Pd630_LPD05803  Protein icc [KO:K03651] [EC:3.1.4.53]
Pd630_LPD03505  AP-4-A phosphorylase [KO:K19710] [EC:2.7.7.53]
Pd630_LPD05650  Bifunctional enzyme CysN/CysC [KO:K00955] [EC:2.7.7.4 2.7.1.25]
Pd630_LPD05368  Bifunctional enzyme CysN/CysC [KO:K00955] [EC:2.7.7.4 2.7.1.25]
Pd630_LPD05356  Bifunctional enzyme CysN/CysC [KO:K00956] [EC:2.7.7.4]
Pd630_LPD05651  Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
Pd630_LPD05355  Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
Pd630_LPD05367  Sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
Pd630_LPD00958  Uricase [KO:K00365] [EC:1.7.3.3]
Pd630_LPD05707  Uricase [KO:K00365] [EC:1.7.3.3]
Pd630_LPD00959  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
Pd630_LPD05706  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
Pd630_LPD00960  Uric acid degradation bifunctional protein TTL [KO:K16840] [EC:4.1.1.97]
Pd630_LPD05705  Uric acid degradation bifunctional protein TTL [KO:K16840] [EC:4.1.1.97]
Pd630_LPD02149  Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K16840] [EC:4.1.1.97]
Pd630_LPD06795  Hydantoin racemase [KO:K16841] [EC:5.1.99.3]
Pd630_LPD00967  Hydantoin racemase [KO:K16841] [EC:5.1.99.3]
Pd630_LPD00970  Chitin deacetylase 1 [KO:K16842] [EC:3.5.2.5]
Pd630_LPD06799  putative allantoicase [KO:K01477] [EC:3.5.3.4]
Pd630_LPD04631  Uncharacterized protein ylbA [KO:K14977] [EC:3.5.3.26]
Pd630_LPD02283  Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
Pd630_LPD02282  Urease subunit beta [KO:K01429] [EC:3.5.1.5]
Pd630_LPD02281  Urease subunit gamma [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
roa00030  Pentose phosphate pathway
roa00220  Arginine biosynthesis
roa00250  Alanine, aspartate and glutamate metabolism
roa00260  Glycine, serine and threonine metabolism
roa00340  Histidine metabolism
roa00630  Glyoxylate and dicarboxylate metabolism
roa00730  Thiamine metabolism
roa00740  Riboflavin metabolism
roa00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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