KEGG   PATHWAY: sara00564
Entry
sara00564                   Pathway                                
Name
Glycerophospholipid metabolism - Sorex araneus (European shrew)
Class
Metabolism; Lipid metabolism
Pathway map
sara00564  Glycerophospholipid metabolism
sara00564

Module
sara_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:sara00564]
sara_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:sara00564]
sara_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:sara00564]
Other DBs
GO: 0006650
Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101537138  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
101537189  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
101537287  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
101537502  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
101537645  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
101537782  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
101538123  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101538228  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101538617  TAZ; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
101538711  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
101539002  PCYT1B; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
101539420  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
101539517  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
101539683  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
101539739  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
101539747  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101540099  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101540118  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
101540303  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
101540453  [KO:K01047] [EC:3.1.1.4]
101540487  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101540825  [KO:K01047] [EC:3.1.1.4]
101541211  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
101541371  PISD; phosphatidylserine decarboxylase proenzyme [KO:K01613] [EC:4.1.1.65]
101541465  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
101541849  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
101541863  AGPAT6; glycerol-3-phosphate acyltransferase 6 [KO:K13506] [EC:2.3.1.15]
101542317  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101542848  [KO:K01047] [EC:3.1.1.4]
101543025  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
101543251  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
101543265  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
101543498  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101544574  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
101544658  [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101544687  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
101544936  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101545327  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
101545468  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101545504  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
101545661  PPAPDC1B; phosphatidate phosphatase PPAPDC1B [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101545970  ACHE; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
101545998  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101546036  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
101546177  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
101546266  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101546530  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101546720  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
101546809  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
101547429  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
101547507  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
101547805  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
101547904  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101548111  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
101548231  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101548362  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
101548710  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
101548722  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101548816  [KO:K13509] [EC:2.3.1.51]
101549017  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
101549028  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
101549384  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
101549485  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
101549487  PPAP2C; lipid phosphate phosphohydrolase 2 [KO:K01080] [EC:3.1.3.4]
101549504  LCLAT1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
101549789  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
101550007  AGPAT9; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
101550276  [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101550277  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
101550415  PPAP2A; lipid phosphate phosphohydrolase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
101550489  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101550540  [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101550825  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
101551436  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101551481  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
101552144  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
101552233  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
101552475  MBOAT1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101552793  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101552903  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
101553135  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
101553339  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
101553468  [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101553827  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
101554064  SAMD8; sphingomyelin synthase-related protein 1 isoform X2 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
101554086  [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101554285  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [KO:K00006] [EC:1.1.1.8]
101554326  PNPLA7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
101554692  EPT1; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
101555052  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101555205  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101555471  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101555733  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101556310  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X1 [KO:K00006] [EC:1.1.1.8]
101556779  PLD4; phospholipase D4 [KO:K16860] [EC:3.1.4.4]
101556848  PPAPDC1A; phosphatidate phosphatase PPAPDC1A [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101557133  [KO:K00981] [EC:2.7.7.41]
101557459  PNPLA6; neuropathy target esterase isoform X1 [KO:K14676] [EC:3.1.1.5]
101557523  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101557528  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101558054  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
101558469  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
101558750  [KO:K01047] [EC:3.1.1.4]
101558884  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
101559060  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
101559338  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
105943339  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105943340  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
sara00010  Glycolysis / Gluconeogenesis
sara00260  Glycine, serine and threonine metabolism
sara00561  Glycerolipid metabolism
sara00562  Inositol phosphate metabolism
sara00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
sara00565  Ether lipid metabolism
sara00620  Pyruvate metabolism
KO pathway
ko00564   

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