KEGG   PATHWAY: sasa00830
Entry
sasa00830                   Pathway                                
Name
Retinol metabolism - Salmo salar (Atlantic salmon)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
sasa00830  Retinol metabolism
sasa00830

Other DBs
GO: 0006776
Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
100194842  ud2a2; UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]
100195897  lrat; Lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
100195924  rdh8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
100195937  dhrs4; Dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
100195992  adhx; Alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100196075  rdh12; retinol dehydrogenase 12 (all-trans and 9-cis) [KO:K11153] [EC:1.1.1.300]
100196171  retst; putative all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
100196764  aldh1a2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]
100380445  dhrs3; Short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
101448034  bcmo1; beta-carotene 15,15'-monooxygenase 1 [KO:K00515] [EC:1.13.11.63]
101448035  [KO:K00515] [EC:1.13.11.63]
106560908  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
106561176  [KO:K11153] [EC:1.1.1.300]
106562095  [KO:K00515] [EC:1.13.11.63]
106562207  [KO:K07249] [EC:1.2.1.36]
106562593  [KO:K07249] [EC:1.2.1.36]
106564171  [KO:K11150] [EC:1.1.1.-]
106564172  [KO:K11150] [EC:1.1.1.-]
106566157  [KO:K00061] [EC:1.1.1.315]
106566814  [KO:K11146] [EC:1.1.1.300]
106567102  [KO:K00699] [EC:2.4.1.17]
106567841  [KO:K00699] [EC:2.4.1.17]
106568073  [KO:K07424] [EC:1.14.14.1]
106568567  [KO:K00699] [EC:2.4.1.17]
106568881  [KO:K15734] [EC:1.1.1.105]
106569137  [KO:K11158] [EC:3.1.1.64 5.3.3.22]
106569221  [KO:K11153] [EC:1.1.1.300]
106569965  [KO:K00699] [EC:2.4.1.17]
106570158  [KO:K11153] [EC:1.1.1.300]
106570407  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
106571445  [KO:K15734] [EC:1.1.1.105]
106572239  [KO:K11146] [EC:1.1.1.300]
106574294  [KO:K00157] [EC:1.2.3.1]
106574372  pnpla4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]
106575224  [KO:K00157] [EC:1.2.3.1]
106575940  [KO:K17951] [EC:1.14.19.53]
106577135  [KO:K12665] [EC:1.14.14.-]
106577136  [KO:K07437] [EC:1.14.14.-]
106577307  [KO:K07437] [EC:1.14.14.-]
106577690  [KO:K00699] [EC:2.4.1.17]
106578148  [KO:K12664] [EC:1.14.14.-]
106578168  [KO:K00678] [EC:2.3.1.135]
106578182  LRAT; lecithin retinol acyltransferase-like [KO:K00678] [EC:2.3.1.135]
106578408  [KO:K11153] [EC:1.1.1.300]
106578413  [KO:K11153] [EC:1.1.1.300]
106579211  rdh13; retinol dehydrogenase 13 [KO:K11161] [EC:1.1.1.300]
106579697  [KO:K11153] [EC:1.1.1.300]
106579731  rdh10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
106580020  [KO:K00699] [EC:2.4.1.17]
106580065  [KO:K07249] [EC:1.2.1.36]
106581797  [KO:K00699] [EC:2.4.1.17]
106581876  [KO:K00699] [EC:2.4.1.17]
106581954  [KO:K00699] [EC:2.4.1.17]
106582983  [KO:K11146] [EC:1.1.1.300]
106583706  [KO:K00061] [EC:1.1.1.315]
106584339  [KO:K11158] [EC:3.1.1.64 5.3.3.22]
106587345  [KO:K07249] [EC:1.2.1.36]
106588337  [KO:K11153] [EC:1.1.1.300]
106588986  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
106589635  [KO:K09516] [EC:1.3.99.23]
106590122  [KO:K00699] [EC:2.4.1.17]
106590215  sdr16c5; short chain dehydrogenase/reductase family 16C member 5 [KO:K15734] [EC:1.1.1.105]
106590669  [KO:K11151] [EC:1.1.1.-]
106591782  [KO:K07424] [EC:1.14.14.1]
106591899  [KO:K07424] [EC:1.14.14.1]
106593045  [KO:K11153] [EC:1.1.1.300]
106593341  [KO:K07424] [EC:1.14.14.1]
106593806  [KO:K00699] [EC:2.4.1.17]
106594168  CP3AR; cytochrome P450 3A27 [KO:K07424] [EC:1.14.14.1]
106595593  [KO:K17951] [EC:1.14.19.53]
106596301  [KO:K07249] [EC:1.2.1.36]
106598856  RDH12; retinol dehydrogenase 12-like [KO:K11153] [EC:1.1.1.300]
106599159  [KO:K15734] [EC:1.1.1.105]
106599325  [KO:K11151] [EC:1.1.1.-]
106600509  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
106600793  [KO:K09516] [EC:1.3.99.23]
106601273  [KO:K11150] [EC:1.1.1.-]
106601275  [KO:K11150] [EC:1.1.1.-]
106602563  [KO:K00678] [EC:2.3.1.135]
106604038  [KO:K00699] [EC:2.4.1.17]
106604039  [KO:K00699] [EC:2.4.1.17]
106605973  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
106606064  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
106606092  [KO:K11153] [EC:1.1.1.300]
106606100  [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
106607200  [KO:K11150] [EC:1.1.1.-]
106607202  [KO:K11150] [EC:1.1.1.-]
106607466  [KO:K09516] [EC:1.3.99.23]
106607892  [KO:K12665] [EC:1.14.14.-]
106607910  [KO:K07437] [EC:1.14.14.-]
106608464  [KO:K12664] [EC:1.14.14.-]
106608682  [KO:K00699] [EC:2.4.1.17]
106608855  [KO:K11147] [EC:1.1.-.-]
106609867  [KO:K00678] [EC:2.3.1.135]
106611488  [KO:K11153] [EC:1.1.1.300]
106611602  ADHX; alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
106613887  [KO:K11158] [EC:3.1.1.64 5.3.3.22]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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