KEGG   PATHWAY: scb00260
Entry
scb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces scabiei
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
scb00260  Glycine, serine and threonine metabolism
scb00260

Module
scb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:scb00260]
scb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:scb00260]
scb_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:scb00260]
scb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:scb00260]
scb_M00555  Betaine biosynthesis, choline => betaine [PATH:scb00260]
scb_M00621  Glycine cleavage system [PATH:scb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces scabiei [GN:scb]
Gene
SCAB_41651  lysC; putative aspartate kinase [KO:K00928] [EC:2.7.2.4]
SCAB_41641  asd1; putative aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SCAB_59621  asd1; aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SCAB_3841  putative homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SCAB_28961  thrA; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SCAB_28941  thrB; putative homoserine kinase [KO:K00872] [EC:2.7.1.39]
SCAB_31711  putative pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
SCAB_50401  putative threonine synthase [KO:K01733] [EC:4.2.3.1]
SCAB_28951  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SCAB_82611  putative aldolase [KO:K01620] [EC:4.1.2.48]
SCAB_6851  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SCAB_35641  glyA1; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SCAB_28851  glyA3; putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SCAB_27491  glyA2; putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SCAB_17701  putative transferase [KO:K00865] [EC:2.7.1.165]
SCAB_49941  gpmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SCAB_53341  putative phosphotransferase [KO:K15634] [EC:5.4.2.11]
SCAB_27051  serA; putative D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SCAB_51101  putative phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SCAB_71401  putative phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SCAB_12671  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SCAB_12681  tdh; threonine 3-dehydrogenase. [KO:K00060] [EC:1.1.1.103]
SCAB_0901  putative flavin-binding oxidoreductase [KO:K00274] [EC:1.4.3.4]
SCAB_14921  aofH; PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE OXIDASE) (MAO) [KO:K00274] [EC:1.4.3.4]
SCAB_76331  putative glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SCAB_27461  gcvT; putative glycine cleavage T protein aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SCAB_67061  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SCAB_27481  gcvH; putative glycine cleavage H protein [KO:K02437]
SCAB_13211  putative D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
SCAB_17681  putative phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SCAB_7031  cudB; putative choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SCAB_76051  putative oxidoreductase [KO:K17755] [EC:1.1.3.17]
SCAB_76071  gbsA; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCAB_7001  gbsA; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCAB_25841  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCAB_25771  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCAB_89381  putative aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SCAB_6961  putative dehydrogenase [KO:K00309] [EC:1.5.3.10]
SCAB_81271  putative sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
SCAB_81171  solA; putative sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
SCAB_81021  solA; putative sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
SCAB_6931  soxA; putative sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
SCAB_6941  soxB; putative sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
SCAB_6921  soxG; putative sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
SCAB_54591  putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SCAB_5301  putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SCAB_46251  cysA; putative cystathionine/methionine gamma-synthase/lyase [KO:K01758] [EC:4.4.1.1]
SCAB_6841  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
SCAB_27501  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
SCAB_8031  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SCAB_89841  putative pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
SCAB_34331  putative amino acid deaminase [KO:K01754] [EC:4.3.1.19]
SCAB_68511  trpA; tryptophan synthase alpha subunit [KO:K01695] [EC:4.2.1.20]
SCAB_68501  trpB; tryptophan synthase beta subunit [KO:K01696] [EC:4.2.1.20]
SCAB_24691  sidA; putative aminotransferase [KO:K00836] [EC:2.6.1.76]
SCAB_70731  ectB; putative diaminobutyrate--2-oxoglutarate transaminase (ectoine biosynthesis) [KO:K00836] [EC:2.6.1.76]
SCAB_0771  putative aminotransferase [KO:K00836] [EC:2.6.1.76]
SCAB_3351  putative aminotransferase [KO:K00836] [EC:2.6.1.76]
SCAB_70741  ectA; putative L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
SCAB_70721  ectC; putative L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
SCAB_70711  ectD; putative ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
SCAB_57951  desA; putative siderophore biosynthesis pyridoxal-dependent decarboxylase DesA [KO:K13745] [EC:4.1.1.86]
SCAB_68801  putative amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
scb00010  Glycolysis / Gluconeogenesis
scb00020  Citrate cycle (TCA cycle)
scb00230  Purine metabolism
scb00250  Alanine, aspartate and glutamate metabolism
scb00270  Cysteine and methionine metabolism
scb00290  Valine, leucine and isoleucine biosynthesis
scb00300  Lysine biosynthesis
scb00330  Arginine and proline metabolism
scb00460  Cyanoamino acid metabolism
scb00470  D-Amino acid metabolism
scb00564  Glycerophospholipid metabolism
scb00600  Sphingolipid metabolism
scb00620  Pyruvate metabolism
scb00630  Glyoxylate and dicarboxylate metabolism
scb00640  Propanoate metabolism
scb00680  Methane metabolism
scb00860  Porphyrin metabolism
scb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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