KEGG   PATHWAY: sho00260
Entry
sho00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces hygroscopicus subsp. jinggangensis TL01
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sho00260  Glycine, serine and threonine metabolism
sho00260

Module
sho_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sho00260]
sho_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sho00260]
sho_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:sho00260]
sho_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sho00260]
sho_M00555  Betaine biosynthesis, choline => betaine [PATH:sho00260]
sho_M00621  Glycine cleavage system [PATH:sho00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces hygroscopicus subsp. jinggangensis TL01 [GN:sho]
Gene
SHJGH_5173  aspartate kinase [KO:K00928] [EC:2.7.2.4]
SHJGH_5174  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SHJGH_3907  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SHJGH_6196  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SHJGH_6198  putative homoserine kinase [KO:K00872] [EC:2.7.1.39]
SHJGH_4588  threonine synthase [KO:K01733] [EC:4.2.3.1]
SHJGH_6197  threonine synthase [KO:K01733] [EC:4.2.3.1]
SHJGH_0435  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
SHJGH_2300  aldolase [KO:K01620] [EC:4.1.2.48]
SHJGH_1608  putative glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SHJGH_5728  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SHJGH_6206  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SHJGH_6319  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SHJGH_7187  glycerate kinase [KO:K00865] [EC:2.7.1.165]
SHJGH_4634  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
SHJGH_6372  putative D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SHJGH_4536  putative aminotransferase [KO:K00831] [EC:2.6.1.52]
SHJGH_3023  3-phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
SHJGH_7437  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
SHJGH_7436  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SHJGH_7091  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SHJGH_4570  putative L-glutamate oxidase [KO:K00274] [EC:1.4.3.4]
SHJGH_8432  tyramine oxidase [KO:K00276] [EC:1.4.3.21]
SHJGH_6924  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
SHJGH_2560  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SHJGH_6321  glycine cleavage system aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SHJGH_0613  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SHJGH_2227  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SHJGH_3424  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SHJGH_6917  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SHJGH_6320  glycine cleavage system H protein [KO:K02437]
SHJGH_7395  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
SHJGH_7188  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SHJGH_2598  choline oxidase [KO:K17755] [EC:1.1.3.17]
SHJGH_8430  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SHJGH_6523  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SHJGH_6506  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SHJGH_2596  glycine betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SHJGH_5714  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SHJGH_0413  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SHJGH_2593  sarcosine dehydrogenase [KO:K00309] [EC:1.5.3.10]
SHJGH_2594  N-methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
SHJGH_1600  hypothetical protein [KO:K18896] [EC:2.1.1.156]
SHJGH_4312  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
SHJGH_4913  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
SHJGH_6318  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SHJGH_5829  amino acid deaminase [KO:K01754] [EC:4.3.1.19]
SHJGH_1911  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SHJGH_3278  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SHJGH_3279  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
SHJGH_8395  tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
SHJGH_8242  tryptophan synthase subunit beta [KO:K06001] [EC:4.2.1.20]
SHJGH_1232  aminotransferase [KO:K00836] [EC:2.6.1.76]
SHJGH_3091  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
SHJGH_6657  class III aminotransferase [KO:K00836] [EC:2.6.1.76]
SHJGH_3090  L-2,4-diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
SHJGH_3092  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
SHJGH_3093  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
SHJGH_8431  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
SHJGH_3256  amino acid decarboxylase [KO:K13745] [EC:4.1.1.86]
SHJGH_4048  decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sho00010  Glycolysis / Gluconeogenesis
sho00020  Citrate cycle (TCA cycle)
sho00230  Purine metabolism
sho00250  Alanine, aspartate and glutamate metabolism
sho00270  Cysteine and methionine metabolism
sho00290  Valine, leucine and isoleucine biosynthesis
sho00300  Lysine biosynthesis
sho00330  Arginine and proline metabolism
sho00460  Cyanoamino acid metabolism
sho00470  D-Amino acid metabolism
sho00564  Glycerophospholipid metabolism
sho00600  Sphingolipid metabolism
sho00620  Pyruvate metabolism
sho00630  Glyoxylate and dicarboxylate metabolism
sho00640  Propanoate metabolism
sho00680  Methane metabolism
sho00860  Porphyrin metabolism
sho00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system