KEGG   PATHWAY: shr00330
Entry
shr00330                    Pathway                                
Name
Arginine and proline metabolism - Sarcophilus harrisii (Tasmanian devil)
Class
Metabolism; Amino acid metabolism
Pathway map
shr00330  Arginine and proline metabolism
shr00330

Module
shr_M00015  Proline biosynthesis, glutamate => proline [PATH:shr00330]
shr_M00047  Creatine pathway [PATH:shr00330]
shr_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:shr00330]
shr_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:shr00330]
shr_M00970  Proline degradation, proline => glutamate [PATH:shr00330]
shr_M00972  Proline metabolism [PATH:shr00330]
Other DBs
GO: 0006525 0006560
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100913437  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100913771  [KO:K00128] [EC:1.2.1.3]
100913804  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
100913891  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
100914782  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
100915360  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
100916958  L3HYPDH; trans-3-hydroxy-L-proline dehydratase [KO:K18384] [EC:4.2.1.77]
100917297  SMOX; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
100917383  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
100918204  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
100918959  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
100919097  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
100919833  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
100919856  [KO:K00274] [EC:1.4.3.4]
100920121  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
100920216  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial [KO:K00286] [EC:1.5.1.2]
100920419  CKMT1A; creatine kinase U-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
100920874  CNDP2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
100921140  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100921246  P4HA3; prolyl 4-hydroxylase subunit alpha-3 [KO:K00472] [EC:1.14.11.2]
100921738  CKB; creatine kinase B-type isoform X1 [KO:K00933] [EC:2.7.3.2]
100921818  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
100922318  AMD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
100922964  CNDP1; beta-Ala-His dipeptidase isoform X1 [KO:K05604] [EC:3.4.13.20]
100922994  SAT2; diamine acetyltransferase 2 [KO:K00657] [EC:2.3.1.57]
100923163  CKM; creatine kinase M-type [KO:K27382]
100923431  [KO:K01581] [EC:4.1.1.17]
100925351  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
100926226  ALDH16A1; LOW QUALITY PROTEIN: aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
100926291  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
100926312  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
100926454  [KO:K01581] [EC:4.1.1.17]
100926458  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
100927789  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100928879  SMS; spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
100929176  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial [KO:K18123] [EC:4.1.3.16]
100929530  SATL1; spermidine/spermine N(1)-acetyltransferase-like protein 1 isoform X1 [KO:K00657] [EC:2.3.1.57]
100929799  DAO; LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
100929889  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
100930576  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100930697  AGMAT; agmatinase, mitochondrial [KO:K27001]
100931027  ALDH1B1; aldehyde dehydrogenase X, mitochondrial isoform X2 [KO:K00128] [EC:1.2.1.3]
100931276  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X2 [KO:K00472] [EC:1.14.11.2]
100931813  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
100932003  SRM; spermidine synthase [KO:K00797] [EC:2.5.1.16]
100932529  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100933253  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
100933609  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
100934818  CARNS1; LOW QUALITY PROTEIN: carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
100935241  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
105749676  [KO:K00318] [EC:1.5.5.2]
105749810  AZIN2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
111719924  PRODH2; hydroxyproline dehydrogenase [KO:K11394] [EC:1.5.5.3]
111719970  [KO:K01581] [EC:4.1.1.17]
116421495  ODC1; ornithine decarboxylase isoform X1 [KO:K01581] [EC:4.1.1.17]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
shr00020  Citrate cycle (TCA cycle)
shr00220  Arginine biosynthesis
shr00250  Alanine, aspartate and glutamate metabolism
shr00260  Glycine, serine and threonine metabolism
shr00270  Cysteine and methionine metabolism
shr00310  Lysine degradation
shr00410  beta-Alanine metabolism
shr00470  D-Amino acid metabolism
shr00480  Glutathione metabolism
shr00630  Glyoxylate and dicarboxylate metabolism
shr00650  Butanoate metabolism
shr00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

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