KEGG PATHWAY: shr00260

PATHWAY: shr00260

Entry

shr00260                    Pathway

Name

Glycine, serine and threonine metabolism - Sarcophilus harrisii (Tasmanian devil)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

shr00260

Glycine, serine and threonine metabolism

Module

shr_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:shr00260]

shr_M00047

Creatine pathway [PATH:shr00260]

shr_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:shr00260]

shr_M00555

Betaine biosynthesis, choline => betaine [PATH:shr00260]

shr_M00621

Glycine cleavage system [PATH:shr00260]

shr_M00974

Betaine metabolism, animals, betaine => glycine [PATH:shr00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Sarcophilus harrisii (Tasmanian devil) [GN:shr]

Gene

100916389

[KO:K00276] [EC:1.4.3.21]

100917001

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

100917044

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

100918390

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

100918619

GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]

100918774

[KO:K15789] [EC:1.1.1.103]

100919118

PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

100919229

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

100919856

[KO:K00274] [EC:1.4.3.4]

100919929

CBS; cystathionine beta-synthase isoform X2 [KO:K01697] [EC:4.2.1.22]

100920121

MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]

100920227

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

100920518

[KO:K01754] [EC:4.3.1.19]

100921337

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

100923413

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

100924960

ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

100925098

[KO:K00552] [EC:2.1.1.20]

100925152

SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

100925411

SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]

100925921

SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]

100926458

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

100926509

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

100927569

BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

100928614

PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

100928696

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

100928831

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

100929336

SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]

100929799

DAO; LOW QUALITY PROTEIN: D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

100930466

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

100930576

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

100930588

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

100931056

[KO:K00276] [EC:1.4.3.21]

100931559

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

100931635

DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]

100932012

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

100933552

AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]

100933609

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

100933854

SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

111720803

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721