KEGG   PATHWAY: smw00260
Entry
smw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Serratia marcescens WW4
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
smw00260  Glycine, serine and threonine metabolism
smw00260

Module
smw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:smw00260]
smw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:smw00260]
smw_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:smw00260]
smw_M00555  Betaine biosynthesis, choline => betaine [PATH:smw00260]
smw_M00621  Glycine cleavage system [PATH:smw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Serratia marcescens WW4 [GN:smw]
Gene
SMWW4_v1c00380  [KO:K01754] [EC:4.3.1.19]
SMWW4_v1c00480  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
SMWW4_v1c06570  [KO:K01079] [EC:3.1.3.3]
SMWW4_v1c06700  ytjC; phosphatase [KO:K15634] [EC:5.4.2.11]
SMWW4_v1c06750  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
SMWW4_v1c06760  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
SMWW4_v1c06770  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SMWW4_v1c10810  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
SMWW4_v1c11150  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
SMWW4_v1c12540  gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]
SMWW4_v1c14950  betB; betaine aldehyde dehydrogenase, NAD-dependent [KO:K00130] [EC:1.2.1.8]
SMWW4_v1c14960  betA; choline dehydrogenase, a flavoprotein [KO:K00108] [EC:1.1.99.1]
SMWW4_v1c16110  [KO:K01758] [EC:4.4.1.1]
SMWW4_v1c16120  [KO:K01697] [EC:4.2.1.22]
SMWW4_v1c16260  [KO:K01752] [EC:4.3.1.17]
SMWW4_v1c16600  ltaE; L-allo-threonine aldolase, PLP-dependent [KO:K01620] [EC:4.1.2.48]
SMWW4_v1c16890  serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
SMWW4_v1c17770  [KO:K00643] [EC:2.3.1.37]
SMWW4_v1c18930  ghrA; glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
SMWW4_v1c23130  ydfG; NADPH-dependent malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SMWW4_v1c24170  [KO:K13745] [EC:4.1.1.86]
SMWW4_v1c24180  [KO:K00836] [EC:2.6.1.76]
SMWW4_v1c24950  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
SMWW4_v1c26810  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
SMWW4_v1c26820  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
SMWW4_v1c28280  [KO:K01752] [EC:4.3.1.17]
SMWW4_v1c35300  [KO:K25316]
SMWW4_v1c37390  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SMWW4_v1c38710  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
SMWW4_v1c40260  gcvP; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
SMWW4_v1c40270  gcvH; glycine cleavage system H protein [KO:K02437]
SMWW4_v1c40280  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SMWW4_v1c40350  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SMWW4_v1c41140  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SMWW4_v1c44470  lysC; aspartokinase III [KO:K00928] [EC:2.7.2.4]
SMWW4_v1c45990  asd; NAD(P)-binding aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SMWW4_v1c46900  ilvA; threonine deaminase [KO:K01754] [EC:4.3.1.19]
SMWW4_v1c47070  [KO:K00382] [EC:1.8.1.4]
SMWW4_v1c47160  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
SMWW4_v1c47510  gpmM; phosphoglycero mutase III, cofactor-independent [KO:K15633] [EC:5.4.2.12]
SMWW4_v1c47540  tdh; NAD(P)-binding threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
SMWW4_v1c47550  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
smw00010  Glycolysis / Gluconeogenesis
smw00020  Citrate cycle (TCA cycle)
smw00230  Purine metabolism
smw00250  Alanine, aspartate and glutamate metabolism
smw00270  Cysteine and methionine metabolism
smw00290  Valine, leucine and isoleucine biosynthesis
smw00300  Lysine biosynthesis
smw00330  Arginine and proline metabolism
smw00460  Cyanoamino acid metabolism
smw00470  D-Amino acid metabolism
smw00564  Glycerophospholipid metabolism
smw00600  Sphingolipid metabolism
smw00620  Pyruvate metabolism
smw00630  Glyoxylate and dicarboxylate metabolism
smw00640  Propanoate metabolism
smw00680  Methane metabolism
smw00860  Porphyrin metabolism
smw00920  Sulfur metabolism
KO pathway
ko00260   

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